Journal ArticleDOI
Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores.
Marshall Plaut,Jacalyn H. Pierce,Cynthia J. Watson,J. Hanley-Hyde,Richard P. Nordan,William E. Paul +5 more
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TLDR
It is shown that cross-linkage of FcεRI on a series of non-transformed murine mast cell lines, or treatment of these cells with calcium ionophores, stimulates increased messenger RNA levels and secretion of a group of lymphokines classically produced by a subset of murine T cell lines (TH2cells).Abstract:
The cross-linkage of high affinity Fc epsilon receptors (Fc epsilon RI) on mast cells and basophils is central to the induction of allergic inflammatory responses. As a result of such cross-linkage, mast cells secrete a variety of preformed biologically active substances, such as histamine, and newly synthesized arachidonic acid metabolites. Here we show that cross-linkage of Fc epsilon RI on a series of nontransformed murine mast cell lines, or treatment of these cells with calcium ionophores, stimulates increased messenger RNA levels and secretion of a group of lymphokines classically produced by a subset of murine T cell lines (TH2 cells). These factors include interleukin-3 (a mast cell growth factor)s interleukin-4 (an IgE 'switch factor'), interleukin-5 (an eosinophil differentiation factor) and interleukin-6 (a factor controlling immunoglobulin secretion). The production of these polypeptide factors by mast cells may have great importance in the induction of allergic and anti-parasite inflammatory responses.read more
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Profibrotic Role for Interleukin-4 in Cardiac Remodeling and Dysfunction.
Hongmei Peng,Zeyd Sarwar,Xiao Ping Yang,Edward L. Peterson,Jiang Xu,Branislava Janic,Nadia Rhaleb,Oscar A. Carretero,Nour Eddine Rhaleb +8 more
TL;DR: In response to angiotensin II administration, IL-4−/− mice had reduced interstitial myocardial fibrosis and were protected from developing dilated cardiomyopathy, which was seen in WT mice.
Journal ArticleDOI
Unravelling the mast cell dilemma: culprit or victim of its generosity?
TL;DR: Mecheri et al. as mentioned in this paper demonstrated that mast cells are qualified to achieve specific immune responses by providing costimulation to CD4 and CD8 T cells, as well as by delivering proliferation and differentiation signals to B cells.
Journal Article
Inhibitory mechanism of aloe single component (alprogen) on mediator release in guinea pig lung mast cells activated with specific antigen-antibody reactions
Jai Youl Ro,Byung-Chul Lee,Ji Young Kim,Yean Jun Chung,Myung Hee Chung,Seung Kee Lee,Tae Hyung Jo,Kyung Hwan Kim,Young In Park +8 more
TL;DR: The data suggest that alprogen purified from aloe inhibits multiple signals as well as blocking Ca(2+) influx caused by mast cells activated with specific antigen-antibody reactions and that then the inhibition of histamine and leukotriene release follows.
Journal ArticleDOI
Mast cells: an expanding pathophysiological role from allergy to other disorders.
TL;DR: The pathophysiological role of mast cells in different diseases, including atherosclerosis, pulmonary hypertension, ischemia-reperfusion injury, male infertility, autoimmune disorders such as rheumatoid arthritis and multiple sclerosis, bladder pain syndrome (interstitial cystitis), anxiety, Alzheimer’s disease, nociception, obesity and diabetes mellitus is discussed.
References
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Journal ArticleDOI
Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators
TL;DR: A 33-nucleotide sequence, comprised entirely of A and T residues and located in the 3'-untranslated region, is conserved in toto in the murine and human TNF mRNAs.
Journal ArticleDOI
Production of hybridoma growth factor by human monocytes.
TL;DR: Limiting dilution analysis of the producing cells in combination with size, density and adherence characteristics showed that HGF is produced by monocytes and not by lymphocytes, and there was no need for the monocytes to be stimulated but the cells did require the presence of serum.
Journal ArticleDOI
Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.
TL;DR: Lymphokine synthesis patterns of a panel of 19 T cell clones have been evaluated, using mRNA hybridization methods to examine 11 different mRNAs induced by Con A, and it is shown that secreted protein and mRNA levels correlated well for all cell lines.
Journal Article
B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.
TL;DR: Highly purified BSF-1 from a different source, the T lymphoma cell line EL-4, enhanced IgE production to the same extent as TH supernatants, which suggests that B SF-1 is responsible for this increase in IgEProduction.
Journal ArticleDOI
The role of helper T cell products in mouse B cell differentiation and isotype regulation.
Robert L. Coffman,Brian W. P. Seymour,Deborah A. Lebman,Debra D. Hiraki,Judy A. Christiansen,B Shrader,Holly M. Cherwinski,Huub F. J. Savelkoul,Fred D. Finkelman,Martha W. Bond,Tim R. Mosmann +10 more
TL;DR: In this article, the authors summarize the efforts to define the specific helper T cells or lymphokines which transmit regulatory signals to B cells, and to clarify the individual events influenced by these signals.
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