Journal ArticleDOI
Math1: an essential gene for the generation of inner ear hair cells.
Nessan A. Bermingham,Bassem A. Hassan,Steven D. Price,Melissa A. Vollrath,Nissim Ben-Arie,Ruth Anne Eatock,Hugo J. Bellen,Anna Lysakowski,Huda Y. Zoghbi +8 more
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TLDR
Math1, a mouse homolog of the Drosophila proneural gene atonal, is expressed in inner ear sensory epithelia, and this gene is thus required for the genesis of hair cells.Abstract:
The mammalian inner ear contains the cochlea and vestibular organs, which are responsible for hearing and balance, respectively. The epithelia of these sensory organs contain hair cells that function as mechanoreceptors to transduce sound and head motion. The molecular mechanisms underlying hair cell development and differentiation are poorly understood. Math1, a mouse homolog of theDrosophila proneural gene atonal, is expressed in inner ear sensory epithelia. Embryonic Math1-null mice failed to generate cochlear and vestibular hair cells. This gene is thus required for the genesis of hair cells.read more
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Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms.
Mark Eben Massari,Cornelis Murre +1 more
TL;DR: The helix-loop-helix (HLH) family of transcriptional regulatory proteins are key players in a wide array of developmental processes, including neurogenesis, myogenesis, hematopoiesis, and pancreatic development and the structure and functional properties are examined.
Journal ArticleDOI
Proneural genes and the specification of neural cell types
TL;DR: Parallel studies in Drosophila and vertebrates have revealed that proneural genes are key regulators of neurogenesis, coordinating the acquisition of a generic neuronal fate and of specific subtype identities that are appropriate for the location and time of neuronal generation.
Journal ArticleDOI
Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears.
J L Zheng,Wei-Qiang Gao +1 more
TL;DR: It is reported here that overexpression of Math1, a mouse homolog of the Drosophila gene atonal, in postnatal rat cochlear explant cultures resulted in extra hair cells, and immature postnatal mammalian inner ears retained the competence to generate new hair cells.
Journal ArticleDOI
Organizing cell renewal in the intestine : stem cells, signals and combinatorial control
TL;DR: A flurry of recent papers has clarified the key regulatory signals and brought us to the point where the authors can begin to give a coherent account, for at least one tissue, of how these signals collaborate to organize the architecture and behaviour of a stem-cell system.
Journal ArticleDOI
TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells
David P. Corey,David P. Corey,Jaime García-Añoveros,Jeffrey R. Holt,Kelvin Y. Kwan,Kelvin Y. Kwan,Shuh Yow Lin,Shuh Yow Lin,Melissa A. Vollrath,Melissa A. Vollrath,Andrea Amalfitano,Eunice L.M. Cheung,Bruce Derfler,Bruce Derfler,Anne Duggan,Gwenaëlle S. G. Géléoc,Paul A. Gray,Matthew P. Hoffman,Heidi L. Rehm,Daniel Tamasauskas,Daniel Tamasauskas,Duan Sun Zhang,Duan Sun Zhang +22 more
TL;DR: Inhibition of TRPA1 protein expression in zebrafish and mouse inner ears inhibits receptor cell function, as assessed with electrical recording and with accumulation of a channel-permeant fluorescent dye.
References
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Journal ArticleDOI
The myoD gene family: nodal point during specification of the muscle cell lineage
Harold Weintraub,Robert B. Davis,Stephen J Tapscott,Matthew Thayer,Michael Krause,Robert Benezra,T. Keith Blackwell,David L. Turner,Ralph A.W. Rupp,Stanley M. Hollenberg,Yuan Zhuang,Andrew Lassar +11 more
TL;DR: The myoD gene converts many differentiated cell types into muscle, and the helix-loop-helix motif is responsible for dimerization, and, depending on itsDimerization partner, MyoD activity can be controlled.
Journal ArticleDOI
Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice.
G Friedrich,Philippe Soriano +1 more
TL;DR: Intercrossing of heterozygotes from 24 strains that express beta-galactosidase identified 9 strains in which homozygosity leads to an embryonic lethality, suggesting that a substantial proportion of mammalian genes identified by this approach are not essential for development.
Journal ArticleDOI
Math1 is essential for genesis of cerebellar granule neurons.
Nissim Ben-Arie,Hugo J. Bellen,Dawna L. Armstrong,Alanna E. McCall,Polina R. Gordadze,Qiuxia Guo,Martin M. Matzuk,Huda Y. Zoghbi +7 more
TL;DR: It is reported that mice lacking Math1 fail to form granule cells and are born with a cerebellum that is devoid of an external germinal layer, the first gene to be shown to be required in vivo for the genesis of granules cells, and hence the predominant neuronal population in the cerebellums.
Journal ArticleDOI
atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system
TL;DR: It is found that ectopic expression of the ASC genes promotes external sense organ formation exclusively, whereas ato promotes chordotonal organ formation preferentially, indicating that proneural genes are major determinants of neuronal identity.
Journal ArticleDOI
Unconventional Myosins in Inner-Ear Sensory Epithelia
Tama Hasson,Peter G. Gillespie,Jesus A. Garcia,Richard B. MacDonald,Yi Dong Zhao,Ann G. Yee,Mark S. Mooseker,David P. Corey +7 more
TL;DR: This work examined the distribution of four unconventional myosin isozymes in the inner ear, a tissue that is particularly reliant on actin-rich structures and unconventionalMyosin wasozymes, and localization results suggest specific functions for three hair-cell myosins.
Related Papers (5)
Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears.
J L Zheng,Wei-Qiang Gao +1 more