Journal ArticleDOI
Mathematical modelling and controlled drug delivery: matrix systems.
Mario Grassi,Gabriele Grassi +1 more
TLDR
This review points out the fact that the comprehension of the phenomena ruling drug release from matrix systems is appropriate from both the physical and modelling point of view, although further improvements are always possible and desirable.Abstract:
This paper deals with the physical and mathematical modelling description of drug release from matrix systems. In the introduction, matrix systems are considered in the wide frame of the controlled release systems and the concept of mathematical model is briefly discussed. Then, matrix structure and topology are matched, analysing the characteristics of the three-dimensional network constituting them. In this context, drug release mechanisms are considered with particular emphasis on the key factors ruling the release kinetics, such as matrix swelling, erosion, drug dissolution (re-crystallisation), drug diffusion, drug - polymer interaction, initial drug distribution and particle size distribution (for powdered matrix systems). The mathematical modelling section firstly considers the empirical and semi-empirical models that have the great advantage of showing analytical solutions. Then, the attention is focused on theoretical approaches regarding matrix swelling equilibrium and kinetics, drug dissolution, drug diffusion, drug - polymer interaction, initial drug distribution and matrix erosion. Finally, release kinetics from polydispersed spherical particles is studied. This review points out the fact that the comprehension of the phenomena ruling drug release from matrix systems is appropriate from both the physical and modelling point of view, although further improvements are always possible and desirable.read more
Citations
More filters
Journal ArticleDOI
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
Journal ArticleDOI
Drug release kinetics and transport mechanisms of non-degradable and degradable polymeric delivery systems
Yao Fu,Weiyuan John Kao +1 more
TL;DR: An overview of structure-function relationships of selected non-degradable and degradable polymers as drug delivery matrices is provided to help elucidate the solute transport mechanisms.
Journal Article
Theoretical Description of Hydrogel Swelling: A Review
TL;DR: In this paper, a brief review on existing mathematical models and theories in the field of hydrogel swelling as well as the description of the drug release mechanism from swelling-controlled networks is presented.
Journal ArticleDOI
Desktop 3D printing of controlled release pharmaceutical bilayer tablets.
TL;DR: The printed formulations were evaluated for physical and mechanical properties such as weight variation, friability, hardness and thickness as a comparison to the commercial tablet and were within acceptable range as defined by the international standards stated in the United States Pharmacopoeia (USP).
Journal ArticleDOI
Bioactive electrospun scaffolds delivering growth factors and genes for tissue engineering applications.
Wei Ji,Wei Ji,Yan Sun,Yan Sun,Fang Yang,Jeroen J.J.P. van den Beucken,Mingwen Fan,Zhi Chen,John A. Jansen +8 more
TL;DR: Current techniques that can be used to prepare bioactive electrospun scaffolds, including physical adsorption, blend electrospinning, coaxial electrosp spinning, and covalent immobilization are reviewed.
References
More filters
Book
Numerical heat transfer and fluid flow
TL;DR: In this article, the authors focus on heat and mass transfer, fluid flow, chemical reaction, and other related processes that occur in engineering equipment, the natural environment, and living organisms.
Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book
Physical chemistry of surfaces
TL;DR: In this paper, the authors discuss the nature and properties of liquid interfaces, including the formation of a new phase, nucleation and crystal growth, and the contact angle of surfaces of solids.
Book
Introduction to percolation theory
Dietrich Stauffer,Amnon Aharony +1 more
TL;DR: In this paper, a scaling solution for the Bethe lattice is proposed for cluster numbers and a scaling assumption for cluster number scaling assumptions for cluster radius and fractal dimension is proposed.