Journal ArticleDOI
Mechanical Reliability and In Vitro Bioactivity of 3D-Printed Porous Polylactic Acid-Hydroxyapatite Scaffold
Chander Prakash,Gurminder Singh,Sunpreet Singh,W. L. Linda,Hongyu Zheng,Seeram Ramakrishna,Roger J. Narayan +6 more
TLDR
In this article, the authors investigated the mechanical reliability and in vitro bioactivity of the 3D printed hydroxyapatite (HA) reinforced polylactic acid (PLA) porous scaffolds.Abstract:
The study aimed to investigate the mechanical reliability and in vitro bioactivity of the three-dimensional (3D) printed hydroxyapatite (HA) reinforced polylactic acid (PLA) porous scaffolds. The experiments have been performed to study the effect of HA wt.% in PLA matrix, infill density, and post-printing thermal-stimulus on the flexural and compressive strength. Next to this, the best combination of input parameters, in-response of the observed mechanical properties, was determined to print the test specimens for the analysis of reliability, through Weibull distribution. Further, the fracture morphology of the developed PLA/HA porous scaffolds has been investigated, using scanning electron microscopy, to observe the involved fracture mechanism. Moreover, the in vitro cell-culture with osteoblastic bone marrow mesenchymal stem cells-lines has been studied after 1, 3, and 7 days of seeding. The results of the study highlighted that the processing parameters have a strong impact on the mechanical properties of the 3D printed porous scaffolds. Further, the in vitro analysis showed excellent growth, proliferation, and differentiation of osteoplastic cells. Along with these, the result of the Weibull distribution advocated that the printed porous scaffolds are mechanically reliable. Overall, the present study unequivocally advocates that the 3D printed PLA/HA scaffold can be used for potential tissue engineering and biomedical applications.read more
Citations
More filters
Journal ArticleDOI
Recent advances in 3D-printed polylactide and polycaprolactone-based biomaterials for tissue engineering applications.
Zia Ullah Arif,Muhammad Yasir Khalid,Reza Noroozi,Ali Sadeghianmaryan,Meisam Jalalvand,Mokarram Hossain +5 more
TL;DR: In this paper , the recent advancements in the PLA and PCL biodegradable polymer-based composites as well as their reinforcement with hydrogels and bio-ceramics scaffolds manufactured through 3DP are systematically summarized and the applications of bone, cardiac, neural, vascularized and skin tissue regeneration are thoroughly elucidated.
Journal ArticleDOI
4D bioprinting of smart polymers for biomedical applications: recent progress, challenges, and future perspectives
TL;DR: In this paper , an up-to-date overview of 4D bi-printing technology incorporating bioprinting materials, functionalities of biomaterials as well as the focused approach towards different tissue engineering and regenerative medicine (TERM) applications is presented.
Journal ArticleDOI
Characterization of Friction Stir-Welded Polylactic Acid/Aluminum Composite Primed through Fused Filament Fabrication
Ranvijay Kumar,Nishant Ranjan,Vinay Kumar,Raman Kumar,Jasgurpreet Singh Chohan,Aniket Yadav,Piyush,Shubham Sharma,Chander Prakash,Sunpreet Singh,Sunpreet Singh,Changhe Li +11 more
TL;DR: In this article, a semi-consumable pin profile of polylactic acid (PLA)/Al composite material was used to compensate for material loss and void formation during FSW.
Journal ArticleDOI
Recent Advances in Hydroxyapatite-Based Biocomposites for Bone Tissue Regeneration in Orthopedics
TL;DR: This review summarizes recent advances in HA-based biocomposites for bone regeneration, addressing the most widely employed inorganic matrices, the natural and synthetic polymers used as reinforcing components, and the crosslinkers added to improve the mechanical properties of the scaffolds.
Journal ArticleDOI
A comprehensive review on effect of printing parameters on mechanical properties of FDM printed parts
TL;DR: In this paper, a review of the materials and machine parameters associated with FDM printing and highlights the effect of the mechanical and thermal properties of the material on the durability and strength of the printed objects.
References
More filters
Journal ArticleDOI
Biomimetic porous scaffolds for bone tissue engineering
TL;DR: An overview of the design of ideal biomimetic porous scaffolds for bone tissue engineering is presented, and concepts and techniques including the production of a hierarchical structure on both the macro- and nano-scales, the adjustment of biomechanical properties through structural alignment and chemical components, and the control of the biodegradability of the scaffold and its by-products are discussed.
Journal ArticleDOI
Three-dimensional printing of continuous-fiber composites by in-nozzle impregnation.
Ryosuke Matsuzaki,Masahito Ueda,Masaki Namiki,Tae Kun Jeong,Hirosuke Asahara,Keisuke Horiguchi,Taishi Nakamura,Akira Todoroki,Yoshiyasu Hirano +8 more
TL;DR: The technique enables direct 3D fabrication without the use of molds and may become the standard next-generation composite fabrication methodology.
Journal ArticleDOI
Mechanical properties and shape memory effect of 3D-printed PLA-based porous scaffolds.
TL;DR: PLA/15%HA porous scaffolds obtained by 3D-printing with shape recovery of 98% may be used as self-fitting implant for small bone defect replacement owing to SME and were found to withstand up to three compression-heating-compression cycles without delamination.
Journal ArticleDOI
Multi-shape active composites by 3D printing of digital shape memory polymers.
Jiangtao Wu,Chao Yuan,Zhen Ding,Michael Isakov,Yiqi Mao,Tiejun Wang,Martin L. Dunn,H. Jerry Qi +7 more
TL;DR: A theoretical model is developed to predict the deformation behavior of active composites that can take multiple shapes, depending on the environmental temperature, and has a great potential in 4D printing applications.
Journal ArticleDOI
4D printing of high performance shape memory polymer using stereolithography
TL;DR: In this article, a photopolymer printable by stereolithography apparatus (SLA) which uses a tBA-co-DEGDA network based on dual-component phase switching mechanism to build parts of complex geometries and exhibit shape memory behavior.