Mechanisms and Consequences of Dendritic Cell Migration
TLDR
The molecular traffic signals that govern the migration of DCs throughout their life cycle are reviewed and it is shown that within peripheral tissues, DCs collect antigenic material and then traffic to secondary lymphoid organs, where they communicate with lymphocytes to orchestrate adaptive immune responses.About:
This article is published in Immunity.The article was published on 2008-09-19 and is currently open access. It has received 488 citations till now. The article focuses on the topics: Dendritic cell migration & Follicular dendritic cells.read more
Citations
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Journal ArticleDOI
Lymphangiogenesis: Molecular Mechanisms and Future Promise
Tuomas Tammela,Kari Alitalo +1 more
TL;DR: The growth of lymphatic vessels is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients suffering from lymphedema, a debilitating condition characterized by chronic tissue edema and impaired immunity.
Journal ArticleDOI
The lymphatic vasculature in disease
TL;DR: This review highlights the most recent developments in lymphatic biology and how the lymphatic system contributes to the pathogenesis of various diseases involving immune and inflammatory responses and its role in disseminating tumor cells.
Journal ArticleDOI
AS04, an aluminum salt- and TLR4 agonist-based adjuvant system, induces a transient localized innate immune response leading to enhanced adaptive immunity.
Arnaud Didierlaurent,Sandra Morel,Laurence Lockman,Sandra L. Giannini,Michel Bisteau,Harald Carlsen,Anders Kielland,Olivier Vosters,Nathalie Vanderheyde,Francesca Schiavetti,Daniel Larocque,Marcelle Van Mechelen,Nathalie Garçon +12 more
TL;DR: Results support a model in which the addition of MPL to aluminum salt enhances the vaccine response by rapidly triggering a local cytokine response leading to an optimal activation of APCs, and support the favorable safety profile of AS04 adjuvanted vaccines.
Journal ArticleDOI
HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes
Jean-Philippe Girard,Christine Moussion,Christine Moussion,Christine Moussion,Reinhold Förster +4 more
TL;DR: The current understanding of the functions of high endothelial venules, stroma and lymphatics in the entry, positioning and exit of immune cells in lymph nodes during homeostasis are reviewed, and the unexpected role of dendritic cells is highlighted in the control of lymphocyte homing through HEVs.
Book ChapterDOI
How Tolerogenic Dendritic Cells Induce Regulatory T Cells
TL;DR: Recent advances in the understanding of the relationship between tolerogenic DCs and Tregs are reviewed.
References
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Journal ArticleDOI
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
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Immunobiology of Dendritic Cells
Jacques Banchereau,Francine Brière,Christophe Caux,Jean Davoust,Serge Lebecque,Yong-Jun Liu,Bali Pulendran,Karolina Palucka +7 more
TL;DR: Dendritic cells are antigen-presenting cells with a unique ability to induce primary immune responses and may be important for the induction of immunological tolerance, as well as for the regulation of the type of T cell-mediated immune response.
Journal ArticleDOI
Monocyte and macrophage heterogeneity
Siamon Gordon,Philip R. Taylor +1 more
TL;DR: Recent studies have shown that monocyte heterogeneity is conserved in humans and mice, allowing dissection of its functional relevance: the different monocyte subsets seem to reflect developmental stages with distinct physiological roles, such as recruitment to inflammatory lesions or entry to normal tissues.
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Getting to the site of inflammation: the leukocyte adhesion cascade updated
TL;DR: This Review focuses on new aspects of one of the central paradigms of inflammation and immunity — the leukocyte adhesion cascade.
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Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
TL;DR: Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, two functional subsets among murine blood monocytes are identified: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited to inflamed tissues and a CX (3) CR1(hi)CCS1-dependent recruitment to noninflamed tissues.