Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus.
Bahare Salehi,Nanjangud V. Anil Kumar,Bilge Sener,Mehdi Sharifi-Rad,Mehtap Kilic,Gail B. Mahady,Sanja Vlaisavljevic,Marcello Iriti,Farzad Kobarfard,William N. Setzer,Seyed Abdulmajid Ayatollahi,Seyed Abdulmajid Ayatollahi,Athar Ata,Javad Sharifi-Rad,Javad Sharifi-Rad +14 more
TLDR
A survey of plants that have shown anti-HIV activity, both in vitro and in vivo is presented, to provide therapeutic options for populations with limited resources or access to currently efficacious chemotherapies.Abstract:
Since the beginning of the epidemic, human immunodeficiency virus (HIV) has infected around 70 million people worldwide, most of whom reside is sub-Saharan Africa. There have been very promising developments in the treatment of HIV with anti-retroviral drug cocktails. However, drug resistance to anti-HIV drugs is emerging, and many people infected with HIV have adverse reactions or do not have ready access to currently available HIV chemotherapies. Thus, there is a need to discover new anti-HIV agents to supplement our current arsenal of anti-HIV drugs and to provide therapeutic options for populations with limited resources or access to currently efficacious chemotherapies. Plant-derived natural products continue to serve as a reservoir for the discovery of new medicines, including anti-HIV agents. This review presents a survey of plants that have shown anti-HIV activity, both in vitro and in vivo.read more
Citations
More filters
Journal Article
Male circumcision for HIV prevention in young men in Kisumu, Kenya : a randomised controlled trial. Commentary
Marie-Louise Newell,Till Bärnighausen,Robert C. Bailey,Stephen Moses,Corette B. Parker,Kawango Agot,Ian Maclean,John N. Krieger,Carolyn Williams,Richard T. Campbell,Jeckoniah O. Ndinya-Achola +10 more
TL;DR: Male circumcision significantly reduces the risk of HIV acquisition in young men in Africa and should be integrated with other HIV preventive interventions and provided as expeditiously as possible.
Journal ArticleDOI
Antidiabetic Potential of Medicinal Plants and Their Active Components.
Bahare Salehi,Athar Ata,Nanjangud V. Anil Kumar,Farukh Sharopov,Karina Ramírez-Alarcón,Ana M. Ruiz-Ortega,Seyed Abdulmajid Ayatollahi,Patrick Valere Tsouh Fokou,Farzad Kobarfard,Zainul Amiruddin Zakaria,Zainul Amiruddin Zakaria,Marcello Iriti,Yasaman Taheri,Miquel Martorell,Antoni Sureda,William N. Setzer,Alessandra Durazzo,Massimo Lucarini,Antonello Santini,Raffaele Capasso,Elise Adrian Ostrander,Atta-ur-Rahman,Muhammad Iqbal Choudhary,William C. Cho,Javad Sharifi-Rad +24 more
TL;DR: Examples of medicinal plants with antidiabetic potential are described, with focuses on preclinical and clinical studies.
Journal ArticleDOI
Sulfonated and sulfated chitosan derivatives for biomedical applications: A review.
TL;DR: An overview of the strategies used to chemically modify chitosan by introduction of sulfonate groups on chitOSan backbone is provided, focusing on various sulfonating or sulfating agents used and substitution regioselectivity, and highlights their applications in biomedical field.
Journal ArticleDOI
Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion.
Mehdi Sharifi-Rad,Patrick Valere Tsouh Fokou,Farukh Sharopov,Miquel Martorell,Adedayo O. Ademiluyi,Jovana Rajkovic,Bahare Salehi,Natália Martins,Marcello Iriti,Javad Sharifi-Rad,Javad Sharifi-Rad +10 more
TL;DR: From traditional uses as herbal remedies to preclinical evidence, critically discussing the in vitro and in vivo studies focusing on plant extracts and even isolated phytochemicals with antiulcerogenic potential, comprehensively reviewed the plant sources used as antiulcers agents.
Journal ArticleDOI
Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning.
TL;DR: In this paper, a workflow of combined in silico methods (virtual drug screening, molecular docking and supervised machine learning algorithms) was applied to identify novel drug candidates against COVID-19.
References
More filters
Journal ArticleDOI
An evaluation of the RNase H inhibitory effects of Vietnamese medicinal plant extracts and natural compounds.
Bui Huu Tai,Nguyen Duy Nhut,Nguyen Xuan Nhiem,Tran Hong Quang,Nguyen Thi Thanh Ngan,Bui Thi Thuy Luyen,Tran Thu Huong,Jennifer A. Wilson,John A. Beutler,Ninh Khac Ban,Nguyen Manh Cuong,Young Ho Kim +11 more
TL;DR: The screening results demonstrated that the butanol (BuOH) extract of Celastrus orbiculata leaves, methanol (MeOH) extracts of Glycosmis stenocarpa stems, Eurya ciliata Leaves, and especially P. reticulatus leaves showed potential RNase H inhibition and protection against the viral cytopathic effects of HIV-1.
Journal ArticleDOI
In vitro antiplasmodial and HIV-1 neutralization activities of root and leaf extracts from Berberis holstii
TL;DR: The crude alkaloid Extract of the roots showed the most potent anti-parasitic activity and the aqueous extract of the leaves displayed good HIV neutralizing activity against the HXB2 pseudo virus and all the extracts tested displayed low cytotoxicity against TZM-bl cells.
Journal ArticleDOI
Acetone and methanol fruit extracts of Terminalia paniculata inhibit HIV-1 infection in vitro
Ankita Durge,Pratiksha Jadaun,Ashish Wadhwani,Ashish A. Chinchansure,Madhukar S. Said,Hirekodathakallu V. Thulasiram,Swati P. Joshi,Smita Kulkarni +7 more
TL;DR: Both the extracts showed anti-HIV1 activity in a dose-dependent manner and the mechanism of action was indicated to be due to inhibition of reverse transcriptase and protease enzymes.
Journal ArticleDOI
Inhibition on HIV-1 integrase activity and nitric oxide production of compounds from Ficus glomerata.
TL;DR: An ethanol Ficus glomerata wood extract and its purified components were investigated for their HIV-1 integrase (IN) and nitric oxide (NO) inhibitory activities and the inhibitory effect on NO production.
Related Papers (5)
Plants of the Genus Zingiber as a Source of Bioactive Phytochemicals: From Tradition to Pharmacy
Mehdi Sharifi-Rad,Elena Maria Varoni,Bahare Salehi,Javad Sharifi-Rad,Javad Sharifi-Rad,Karl R. Matthews,Seyed Abdulmajid Ayatollahi,Seyed Abdulmajid Ayatollahi,Farzad Kobarfard,Salam A. Ibrahim,Dima Mnayer,Zainul Amiruddin Zakaria,Zainul Amiruddin Zakaria,Majid Sharifi-Rad,Zubaida Yousaf,Marcello Iriti,Adriana Basile,Daniela Rigano +17 more
Medicinal plants used in the treatment of tuberculosis - Ethnobotanical and ethnopharmacological approaches.
Javad Sharifi-Rad,Bahare Salehi,Zorica Stojanović-Radić,Patrick Valere Tsouh Fokou,M. Sharifi-Rad,Gail B. Mahady,Majid Sharifi-Rad,Mohammad Reza Masjedi,Temitope O. Lawal,Seyed Abdulmajid Ayatollahi,Javid Masjedi,Razieh Sharifi-Rad,William N. Setzer,Mehdi Sharifi-Rad,Farzad Kobarfard,Atta-ur Rahman,Muhammad Iqbal Choudhary,Athar Ata,Marcello Iriti +18 more