Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus.
Bahare Salehi,Nanjangud V. Anil Kumar,Bilge Sener,Mehdi Sharifi-Rad,Mehtap Kilic,Gail B. Mahady,Sanja Vlaisavljevic,Marcello Iriti,Farzad Kobarfard,William N. Setzer,Seyed Abdulmajid Ayatollahi,Seyed Abdulmajid Ayatollahi,Athar Ata,Javad Sharifi-Rad,Javad Sharifi-Rad +14 more
TLDR
A survey of plants that have shown anti-HIV activity, both in vitro and in vivo is presented, to provide therapeutic options for populations with limited resources or access to currently efficacious chemotherapies.Abstract:
Since the beginning of the epidemic, human immunodeficiency virus (HIV) has infected around 70 million people worldwide, most of whom reside is sub-Saharan Africa. There have been very promising developments in the treatment of HIV with anti-retroviral drug cocktails. However, drug resistance to anti-HIV drugs is emerging, and many people infected with HIV have adverse reactions or do not have ready access to currently available HIV chemotherapies. Thus, there is a need to discover new anti-HIV agents to supplement our current arsenal of anti-HIV drugs and to provide therapeutic options for populations with limited resources or access to currently efficacious chemotherapies. Plant-derived natural products continue to serve as a reservoir for the discovery of new medicines, including anti-HIV agents. This review presents a survey of plants that have shown anti-HIV activity, both in vitro and in vivo.read more
Citations
More filters
Journal Article
Male circumcision for HIV prevention in young men in Kisumu, Kenya : a randomised controlled trial. Commentary
Marie-Louise Newell,Till Bärnighausen,Robert C. Bailey,Stephen Moses,Corette B. Parker,Kawango Agot,Ian Maclean,John N. Krieger,Carolyn Williams,Richard T. Campbell,Jeckoniah O. Ndinya-Achola +10 more
TL;DR: Male circumcision significantly reduces the risk of HIV acquisition in young men in Africa and should be integrated with other HIV preventive interventions and provided as expeditiously as possible.
Journal ArticleDOI
Antidiabetic Potential of Medicinal Plants and Their Active Components.
Bahare Salehi,Athar Ata,Nanjangud V. Anil Kumar,Farukh Sharopov,Karina Ramírez-Alarcón,Ana M. Ruiz-Ortega,Seyed Abdulmajid Ayatollahi,Patrick Valere Tsouh Fokou,Farzad Kobarfard,Zainul Amiruddin Zakaria,Zainul Amiruddin Zakaria,Marcello Iriti,Yasaman Taheri,Miquel Martorell,Antoni Sureda,William N. Setzer,Alessandra Durazzo,Massimo Lucarini,Antonello Santini,Raffaele Capasso,Elise Adrian Ostrander,Atta-ur-Rahman,Muhammad Iqbal Choudhary,William C. Cho,Javad Sharifi-Rad +24 more
TL;DR: Examples of medicinal plants with antidiabetic potential are described, with focuses on preclinical and clinical studies.
Journal ArticleDOI
Sulfonated and sulfated chitosan derivatives for biomedical applications: A review.
TL;DR: An overview of the strategies used to chemically modify chitosan by introduction of sulfonate groups on chitOSan backbone is provided, focusing on various sulfonating or sulfating agents used and substitution regioselectivity, and highlights their applications in biomedical field.
Journal ArticleDOI
Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion.
Mehdi Sharifi-Rad,Patrick Valere Tsouh Fokou,Farukh Sharopov,Miquel Martorell,Adedayo O. Ademiluyi,Jovana Rajkovic,Bahare Salehi,Natália Martins,Marcello Iriti,Javad Sharifi-Rad,Javad Sharifi-Rad +10 more
TL;DR: From traditional uses as herbal remedies to preclinical evidence, critically discussing the in vitro and in vivo studies focusing on plant extracts and even isolated phytochemicals with antiulcerogenic potential, comprehensively reviewed the plant sources used as antiulcers agents.
Journal ArticleDOI
Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning.
TL;DR: In this paper, a workflow of combined in silico methods (virtual drug screening, molecular docking and supervised machine learning algorithms) was applied to identify novel drug candidates against COVID-19.
References
More filters
Journal ArticleDOI
Phytochemical analysis of Geigeria alata and Francoeuria crispa essential oils.
Samir A. Ross,Khalid A. El Sayed,Mahmoud A. El Sohly,Mark T. Hamann,Osama B. Abdel-Halim,Atallah F. Ahmed,Mamdouh M. Ahmed +6 more
TL;DR: Phytochemical analyses of Geigeria alata and Francoeuria crispa essential oils showed moderate in vitro cytotoxicity and showed weak anti-HIV activity, and its structure was elucidated by 2D-NMR analysis.
Journal ArticleDOI
Antibacterial, anti-HIV-1 protease and cytotoxic activities of aqueous ethanolic extracts from Combretum adenogonium Steud. Ex A. Rich (Combretaceae).
TL;DR: Results provide promising baseline information for the potential development of C. adenogonium extracts in treatment of bacterial and HIV/AIDS-related opportunistic infections.
Journal ArticleDOI
Prenylisoflavonoids from Erythrina senegalensis as novel HIV-1 protease inhibitors.
Ji Suk Lee,Won Keun Oh,Jong Seog Ahn,Yong Hae Kim,J. Tanyi Mbafor,Jean Wandji,Z. Tanee Fomum +6 more
TL;DR: 6,8-diprenylgenistein with two prenyl groups in the 6 and 8 positions of the A ring and one hydroxy group in the 4' position of B-ring was the most potent HIV-1 PR inhibitor.
Journal ArticleDOI
Tulbaghia alliacea phytotherapy: a potential anti-infective remedy for candidiasis.
S. Thamburan,Jeremy A. Klaasen,Wilfred T. Mabusela,John F. Cannon,John F. Cannon,William R. Folk,William R. Folk,Quinton Johnson +7 more
TL;DR: This investigation confirms that extracts of T. alliacea exhibit anti‐infective activity against candida species in vitro, and indicates that the greatest concentrations of inhibitory components were extracted by chloroform or water.
Journal ArticleDOI
Phytochemical and biological investigations of Elaeodendron schlechteranum.
Sheila M. Maregesi,Sheila M. Maregesi,Nina Hermans,Liene Dhooghe,K. Cimanga,Daneel Ferreira,Christophe Pannecouque,Dirk Vanden Berghe,Paul Cos,Louis Maes,Arnold J. Vlietinck,Sandra Apers,Luc Pieters +12 more
TL;DR: Phytochemical investigation of the anti-HIV active fractions led to the isolation and identification of three phenolic compounds, namely 4'-O-methylepigallocatechin, 4-O-methylgallocatechin and a new procyanidin dimer, however, none of these showed anti-hIV activity.
Related Papers (5)
Plants of the Genus Zingiber as a Source of Bioactive Phytochemicals: From Tradition to Pharmacy
Mehdi Sharifi-Rad,Elena Maria Varoni,Bahare Salehi,Javad Sharifi-Rad,Javad Sharifi-Rad,Karl R. Matthews,Seyed Abdulmajid Ayatollahi,Seyed Abdulmajid Ayatollahi,Farzad Kobarfard,Salam A. Ibrahim,Dima Mnayer,Zainul Amiruddin Zakaria,Zainul Amiruddin Zakaria,Majid Sharifi-Rad,Zubaida Yousaf,Marcello Iriti,Adriana Basile,Daniela Rigano +17 more
Medicinal plants used in the treatment of tuberculosis - Ethnobotanical and ethnopharmacological approaches.
Javad Sharifi-Rad,Bahare Salehi,Zorica Stojanović-Radić,Patrick Valere Tsouh Fokou,M. Sharifi-Rad,Gail B. Mahady,Majid Sharifi-Rad,Mohammad Reza Masjedi,Temitope O. Lawal,Seyed Abdulmajid Ayatollahi,Javid Masjedi,Razieh Sharifi-Rad,William N. Setzer,Mehdi Sharifi-Rad,Farzad Kobarfard,Atta-ur Rahman,Muhammad Iqbal Choudhary,Athar Ata,Marcello Iriti +18 more