Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus.
Bahare Salehi,Nanjangud V. Anil Kumar,Bilge Sener,Mehdi Sharifi-Rad,Mehtap Kilic,Gail B. Mahady,Sanja Vlaisavljevic,Marcello Iriti,Farzad Kobarfard,William N. Setzer,Seyed Abdulmajid Ayatollahi,Seyed Abdulmajid Ayatollahi,Athar Ata,Javad Sharifi-Rad,Javad Sharifi-Rad +14 more
TLDR
A survey of plants that have shown anti-HIV activity, both in vitro and in vivo is presented, to provide therapeutic options for populations with limited resources or access to currently efficacious chemotherapies.Abstract:
Since the beginning of the epidemic, human immunodeficiency virus (HIV) has infected around 70 million people worldwide, most of whom reside is sub-Saharan Africa. There have been very promising developments in the treatment of HIV with anti-retroviral drug cocktails. However, drug resistance to anti-HIV drugs is emerging, and many people infected with HIV have adverse reactions or do not have ready access to currently available HIV chemotherapies. Thus, there is a need to discover new anti-HIV agents to supplement our current arsenal of anti-HIV drugs and to provide therapeutic options for populations with limited resources or access to currently efficacious chemotherapies. Plant-derived natural products continue to serve as a reservoir for the discovery of new medicines, including anti-HIV agents. This review presents a survey of plants that have shown anti-HIV activity, both in vitro and in vivo.read more
Citations
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Male circumcision for HIV prevention in young men in Kisumu, Kenya : a randomised controlled trial. Commentary
Marie-Louise Newell,Till Bärnighausen,Robert C. Bailey,Stephen Moses,Corette B. Parker,Kawango Agot,Ian Maclean,John N. Krieger,Carolyn Williams,Richard T. Campbell,Jeckoniah O. Ndinya-Achola +10 more
TL;DR: Male circumcision significantly reduces the risk of HIV acquisition in young men in Africa and should be integrated with other HIV preventive interventions and provided as expeditiously as possible.
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Antidiabetic Potential of Medicinal Plants and Their Active Components.
Bahare Salehi,Athar Ata,Nanjangud V. Anil Kumar,Farukh Sharopov,Karina Ramírez-Alarcón,Ana M. Ruiz-Ortega,Seyed Abdulmajid Ayatollahi,Patrick Valere Tsouh Fokou,Farzad Kobarfard,Zainul Amiruddin Zakaria,Zainul Amiruddin Zakaria,Marcello Iriti,Yasaman Taheri,Miquel Martorell,Antoni Sureda,William N. Setzer,Alessandra Durazzo,Massimo Lucarini,Antonello Santini,Raffaele Capasso,Elise Adrian Ostrander,Atta-ur-Rahman,Muhammad Iqbal Choudhary,William C. Cho,Javad Sharifi-Rad +24 more
TL;DR: Examples of medicinal plants with antidiabetic potential are described, with focuses on preclinical and clinical studies.
Journal ArticleDOI
Sulfonated and sulfated chitosan derivatives for biomedical applications: A review.
TL;DR: An overview of the strategies used to chemically modify chitosan by introduction of sulfonate groups on chitOSan backbone is provided, focusing on various sulfonating or sulfating agents used and substitution regioselectivity, and highlights their applications in biomedical field.
Journal ArticleDOI
Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion.
Mehdi Sharifi-Rad,Patrick Valere Tsouh Fokou,Farukh Sharopov,Miquel Martorell,Adedayo O. Ademiluyi,Jovana Rajkovic,Bahare Salehi,Natália Martins,Marcello Iriti,Javad Sharifi-Rad,Javad Sharifi-Rad +10 more
TL;DR: From traditional uses as herbal remedies to preclinical evidence, critically discussing the in vitro and in vivo studies focusing on plant extracts and even isolated phytochemicals with antiulcerogenic potential, comprehensively reviewed the plant sources used as antiulcers agents.
Journal ArticleDOI
Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning.
TL;DR: In this paper, a workflow of combined in silico methods (virtual drug screening, molecular docking and supervised machine learning algorithms) was applied to identify novel drug candidates against COVID-19.
References
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Journal ArticleDOI
Anti-HIV-1 activities of extracts from the medicinal plant Rhus chinensis.
TL;DR: Results showed that RC-1 was effective against HIV-1 and Rhus chinensis would be a useful medicinal plant for the chemotherapy of HIV- 1 infection.
Journal ArticleDOI
Antitumor germacranolides from Anvillea garcinii.
TL;DR: The aerial parts of Anvillea garcinii yielded two new germacranolides, 9 alpha-hydroxy-1 beta, 10 alpha-epoxyparthenolide and parthenolid-9-one, and the hitherto unreported 13C-NMR data and carbon atom assignments of the previously isolated lactones 1, 2, and 3 were given.
Journal ArticleDOI
Anti HIV-1 Flavonoid Glycosides from Ochna integerrima
Vichai Reutrakul,Niwat Ningnuek,Manat Pohmakotr,Chalobon Yoosook,Chanita Napaswad,Jitra Kasisit,Thawatchai Santisuk,Patoomratana Tuchinda +7 more
TL;DR: Bioassay-guided fractionation of the anti-HIV-1 active EtOAc extract from leaves and twigs of Ochna integerrima led to the isolation of five new flavonoid glycosides 1 - 5, five known flavonoids 6 - 10, and two known flavonsides 11 and 12, determined based on spectroscopic analyses.
Journal ArticleDOI
Screening of Chinese and Mongolian herbal drugs for anti‐human immunodeficiency virus type 1 (HIV‐1) activity
Chao-Mei Ma,Norio Nakamura,Hirotsugu Miyashiro,Masao Hattori,Katsuko Komatsu,Takuya Kawahata,Toru Otake +6 more
TL;DR: Water and methanol extracts of 30 Chinese and Mongolian medicinal plants were tested for their human immunodeficiency virus type‐1 (HIV‐1) inhibitory activity and led to the isolation of two alkaloids, aromoline and FK‐3000 as potent inhibitory substances.
Journal ArticleDOI
Inhibition of HIV-1 enzymes, antioxidant and anti-inflammatory activities of Plectranthus barbatus
TL;DR: This is the first demonstration of the in vitro anti HIV-1 potential of P. barbatus including direct activity as well as through the stimulation of protective immune and inflammation responses and is in agreement with the vast anecdotal use of this plant in treating various ailments with no reported side-effects.
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