Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus.
Bahare Salehi,Nanjangud V. Anil Kumar,Bilge Sener,Mehdi Sharifi-Rad,Mehtap Kilic,Gail B. Mahady,Sanja Vlaisavljevic,Marcello Iriti,Farzad Kobarfard,William N. Setzer,Seyed Abdulmajid Ayatollahi,Seyed Abdulmajid Ayatollahi,Athar Ata,Javad Sharifi-Rad,Javad Sharifi-Rad +14 more
TLDR
A survey of plants that have shown anti-HIV activity, both in vitro and in vivo is presented, to provide therapeutic options for populations with limited resources or access to currently efficacious chemotherapies.Abstract:
Since the beginning of the epidemic, human immunodeficiency virus (HIV) has infected around 70 million people worldwide, most of whom reside is sub-Saharan Africa. There have been very promising developments in the treatment of HIV with anti-retroviral drug cocktails. However, drug resistance to anti-HIV drugs is emerging, and many people infected with HIV have adverse reactions or do not have ready access to currently available HIV chemotherapies. Thus, there is a need to discover new anti-HIV agents to supplement our current arsenal of anti-HIV drugs and to provide therapeutic options for populations with limited resources or access to currently efficacious chemotherapies. Plant-derived natural products continue to serve as a reservoir for the discovery of new medicines, including anti-HIV agents. This review presents a survey of plants that have shown anti-HIV activity, both in vitro and in vivo.read more
Citations
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Journal ArticleDOI
Methyl Jasmonate Effect on Betulinic Acid Content and Biological Properties of Extract from Senna obtusifolia Transgenic Hairy Roots.
Tomasz Kowalczyk,Przemysław Sitarek,Anna Merecz-Sadowska,Monika Szyposzyńska,Aleksandra Spławska,Leslaw Gorniak,Michal Bijak,Tomasz Śliwiński +7 more
TL;DR: In this paper, an attempt was made to increase the level of betulinic acid accumulation by the cultivation of transgenic hairy roots that overexpress the squalene synthase gene in a 10 L sprinkle bioreactor with methyl jasmonate elicitation.
Journal ArticleDOI
In search of therapeutic candidates for HIV/AIDS: rational approaches, design strategies, structure–activity relationship and mechanistic insights
Dinesh Kumar,Pooja Sharma,Shabu,Ramandeep Kaur,Maloba M. M. Lobe,Girish K. Gupta,Fidele Ntie-Kang,Fidele Ntie-Kang,Fidele Ntie-Kang +8 more
TL;DR: This review article is an effort to summarize recent developments with regards to the discovery of novel analogs with promising biological potential against HIV/AIDS and to discuss prospective directions on the progress of more credible and specific analogues.
Book ChapterDOI
Some Igbo Indigenous Plants with Anti-COVID-19 Properties
TL;DR: Some Igbo indigenous plants in use since the outbreak of COVID-19 are studied and it is suggested that these plants have the properties that alter the PH on the interface between the virus spike proteins and the human respiratory surfaces causing a brake on the interaction with human ACE-2.
Journal ArticleDOI
African Medicinal Plants that Can Control or Cure Tuberculosis
Philip Ifesinachi Anochie,Bakoh Ndingkokhar,Juan Bueno,Felix Emeka Anyiam,Linus Ndidi Ossai Chidi,Edwina Chinwe Onyeneke,Anthony Chidiebere Onyeozirila +6 more
TL;DR: A good number of plant secondary metabolites are reported to have antitubercular activity comparable to the existing antitubcular drugs or sometimes even better.
Book ChapterDOI
An Introduction to Bioactive Natural Products and General Applications
TL;DR: A review on the distribution and geographical sources, phytochemistry, delivery technology, medicinal properties and their general potential applications in agricultural plant protection and pharmaceutical field is presented in this paper.
References
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