MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0
TLDR
An advanced version of the Molecular Evolutionary Genetics Analysis software, which currently contains facilities for building sequence alignments, inferring phylogenetic histories, and conducting molecular evolutionary analysis, is released, which enables the inference of timetrees, as it implements the RelTime method for estimating divergence times for all branching points in a phylogeny.Abstract:
We announce the release of an advanced version of the Molecular Evolutionary Genetics Analysis (MEGA) software, which currently contains facilities for building sequence alignments, inferring phylogenetic histories, and conducting molecular evolutionary analysis. In version 6.0, MEGA now enables the inference of timetrees, as it implements the RelTime method for estimating divergence times for all branching points in a phylogeny. A new Timetree Wizard in MEGA6 facilitates this timetree inference by providing a graphical user interface (GUI) to specify the phylogeny and calibration constraints step-by-step. This version also contains enhanced algorithms to search for the optimal trees under evolutionary criteria and implements a more advanced memory management that can double the size of sequence data sets to which MEGA can be applied. Both GUI and command-line versions of MEGA6 can be downloaded from www.megasoftware.net free of charge.read more
Citations
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Cell wall glucans of fungi. A review.
TL;DR: The most abundant polysaccharides in the cell walls of fungi are glucans, and their structures are highly variable as discussed by the authors, their glucose moieties may be joined through either or both alpha (α) or beta (β) linkages, they are either lineal or branched, and amorphous or microfibrillar.
Journal ArticleDOI
Phylogeny of the Rosidae: A dense taxon sampling analysis
Miao Sun,Rehan Naeem,Jun-Xia Su,Zhi-Yong Cao,J. Gordon Burleigh,Pamela S. Soltis,Pamela S. Soltis,Douglas E. Soltis,Douglas E. Soltis,Zhi-Duan Chen +9 more
TL;DR: This study combines sequences from 9300 species, representing 2775 genera, 138 families, and 17 orders into a supermatrix, and shows the value of a botanically informed bioinformatics approach and dense taxonomic sampling for resolving rosid relationships.
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The Transcriptional Repressor MYB2 Regulates Both Spatial and Temporal Patterns of Proanthocyandin and Anthocyanin Pigmentation in Medicago truncatula
TL;DR: Genetic, biochemical, and cell biological evidence suggests that MYB2 functions as part of a multidimensional regulatory network to define the temporal and spatial pattern of anthocyanin and PA accumulation linked to developmental processes.
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A novel anticancer and antifungus phenazine derivative from a marine actinomycete BM-17
TL;DR: A marine actinomycete, designated strain BM-17, was isolated from a sediment sample collected in the Arctic Ocean and showed significant antifungal activity against Candida albicans and high cancer cell cytotoxicity against HepG2, A549, HCT-116 and COC1 cells.
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A combinational CRISPR/Cas9 gene-editing approach can halt HIV replication and prevent viral escape
Robert Jan Lebbink,Dorien de Jong,Femke Wolters,Elisabeth Kruse,Petra M. van Ham,Emmanuel J. H. J. Wiertz,Monique Nijhuis +6 more
TL;DR: It is demonstrated that CRISPR/Cas9 targeting of single HIV loci, only partially inhibits HIV replication and facilitates rapid viral escape at the target site, and gene-editing may provide a future alternative for control of HIV-infection.
References
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MEGA5: Molecular Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods
Koichiro Tamura,Daniel S. Peterson,Nicholas Peterson,Glen Stecher,Masatoshi Nei,Sudhir Kumar +5 more
TL;DR: The newest addition in MEGA5 is a collection of maximum likelihood (ML) analyses for inferring evolutionary trees, selecting best-fit substitution models, inferring ancestral states and sequences, and estimating evolutionary rates site-by-site.
Journal ArticleDOI
MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment
TL;DR: An overview of the statistical methods, computational tools, and visual exploration modules for data input and the results obtainable in MEGA is provided.
Book
The Neutral Theory of Molecular Evolution
TL;DR: The neutral theory as discussed by the authors states that the great majority of evolutionary changes at the molecular level are caused not by Darwinian selection but by random drift of selectively neutral mutants, which has caused controversy ever since.
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