Meroterpenoids produced by fungi
Regina Geris,Thomas J. Simpson +1 more
TLDR
This review deals with the isolation and structure elucidation of meroterpenoids from higher and lower fungi, and discusses biosynthetic studies and biological activities as appropriate.About:
This article is published in Natural Product Reports.The article was published on 2009-07-22 and is currently open access. It has received 316 citations till now.read more
Citations
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Metabolite induction via microorganism co-culture: A potential way to enhance chemical diversity for drug discovery
TL;DR: Co-culture studies that aim to increase the diversity of metabolites obtained from microbes, with a special emphasis on the multiple methods of performing co-culture experiments, are focused on.
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Biosynthesis of fungal meroterpenoids
Yudai Matsuda,Ikuro Abe +1 more
TL;DR: This review summarizes the molecular bases for their biosyntheses, which were recently elucidated with modern techniques, and also discusses the plausible biosynthetic pathways of other related natural products lacking genetic information.
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The chemistry of isoindole natural products
Klaus Speck,Thomas Magauer +1 more
TL;DR: This review highlights the chemical and biological aspects of natural products containing an oxidized or reduced isoindole skeleton, found in its intact or modified form in indolocarbazoles, macrocyclic polyketides, the aporhoeadane alkaloids, meroterpenoids from Stachybotrys species and anthraquinone-type alkaloid.
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Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse
Vinayak Agarwal,Zachary D. Miles,Jaclyn M. Winter,Alessandra S. Eustáquio,Abrahim El Gamal,Bradley S. Moore +5 more
TL;DR: The scope and mechanism of nature's halogenation and dehalogenation enzymatic strategies are detailed, gaps in understanding are highlighted, and where new advances in the field might arise in the near future are posits.
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Oxidative Cyclization in Natural Product Biosynthesis
TL;DR: This Review examines the different strategies used by nature to create new intra(inter)molecular bonds via redox chemistry, with an emphasis on the former.
References
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Polyketide biosynthesis: a millennium review.
James Staunton,Kira J. Weissman +1 more
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Pharmacology and effects of cannabis: a brief review
TL;DR: Cannabinoids derived from herbal cannabis interact with endogenous cannabinoid systems in the body and cause dose-related impairments of psychomotor performance with implications for car and train driving, aeroplane piloting and academic performance.
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Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets
TL;DR: The current state of knowledge regarding the links between gene sequence, protein architecture and biosynthetic programming for fungal polyketide synthases is outlined.
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Hericenones C, D and E, stimulators of nerve growth factor (NGF)-synthesis, from the mushroom Hericium erinaceum
Hirokazu Kawagishi,Motoharu Ando,Hideki Sakamoto,Satoshi Yoshida,Fumihiro Ojima,Yukio Ishiguro,Nobuo Ukai,Shoei Furukawa +7 more
TL;DR: In this paper, the hericenones C (3), D (4), and D (5 ) from the mushroom Hericium erinaceum were determined by interpretation of the spectral data, and chemical and enzymatic reactions.
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Pyripyropenes, highly potent inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus.
TL;DR: The continuous search has led to the discovery of highly potent ACATinhibitors termed pyripyropene produced by Aspergillus fumigatus FO-1289, and the production, isolation and somebiochemical and biological activities of these compounds are described.