Journal ArticleDOI
Microbubble Ultrasound Contrast Agents: An Update
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TLDR
CEUS with low transmit power allows real-time scanning with the possibility of prolonged organ insonation and tumor-targeted microbubbles make possible the depiction of specific biologic processes.Abstract:
Microbubble contrast agents for ultrasound (US) have gained increasing interest in recent years, and contrast-enhanced US (CEUS) is a rapidly evolving field with applications now extending far beyond the initial improvements achieved in Doppler US. This has been achieved as a result of the safe profile and the increased stability of microbubbles persisting in the bloodstream for several minutes, and also by the availability of specialized contrast-specific US techniques, which allow a definite improvement in the contrast resolution and suppression of signal from stationary tissues. CEUS with low transmit power allows real-time scanning with the possibility of prolonged organ insonation. Several reports have described the effectiveness of microbubble contrast agents in many clinical applications and particularly in the liver, spleen, and kidneys. CEUS allows the assessment of the macrovasculature and microvasculature in different parenchymas, the identification and characterization of hepatic and splenic lesions, the depiction of septal enhancement in cystic renal masses, and the quantification of organ perfusion by the quantitative analysis of the echo-signal intensity. Other fields of application include the assessment of abdominal organs after traumas and the assessment of vesico-ureteral reflux in children. Finally, tumor-targeted microbubbles make possible the depiction of specific biologic processes.read more
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Nanomaterials as photothermal therapeutic agents.
TL;DR: This review article summarizes the current status of employing nanomaterials with photothermal effects for anti-cancer treatment and Mechanisms of the photothermal effect and various factors affecting photothermal performance will be discussed.
Journal ArticleDOI
Superparamagnetic iron oxide nanoparticle-embedded encapsulated microbubbles as dual contrast agents of magnetic resonance and ultrasound imaging.
TL;DR: The interaction between the SPIO-inclusion microbubbles and cells indicates that such microbubble construct can retain the acoustic property under the ultrasound exposure by controlling the SPio concentration in the shell.
Journal ArticleDOI
Combining microbubbles and ultrasound for drug delivery to brain tumors: Current progress and overview
TL;DR: Current preclinical studies which demonstrate the reports by using FUS with MB-facilitated drug delivery technology in brain tumor treatment and newly developed multifunctional theranostic MBs for FUS-induced BBB opening for brain tumor therapy are reviewed.
Journal ArticleDOI
Ultrasound and microbubble mediated drug delivery: acoustic pressure as determinant for uptake via membrane pores or endocytosis.
Ine De Cock,Elisa Zagato,Kevin Braeckmans,Ying Luan,Nico de Jong,Stefaan C. De Smedt,Ine Lentacker +6 more
TL;DR: The first to show that acoustic pressure influences which route of drug uptake is addressed, by inducing different microbubble-cell interactions, is shown, which pinpoints the need for a more rational, microbubbles behavior based choice of acoustic parameters in ultrasound mediated drug delivery experiments.
Journal ArticleDOI
An Algorithm for the Diagnosis of Focal Liver Masses Using Microbubble Contrast-Enhanced Pulse-Inversion Sonography
TL;DR: A simple diagnostic algorithm for interpretation of microbubble contrast-enhanced pulse-inversion sonography provides sensitive and accurate diagnosis of commonly encountered liver masses.
References
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Journal ArticleDOI
New Guidelines to Evaluate the Response to Treatment in Solid Tumors
Patrick Therasse,Susan G. Arbuck,Elizabeth Eisenhauer,Jantien Wanders,Richard Kaplan,Larry Rubinstein,Jaap Verweij,Martine Van Glabbeke,Allan T. van Oosterom,Michaele C. Christian,S. Gwyther +10 more
TL;DR: A model by which a combined assessment of all existing lesions, characterized by target lesions and nontarget lesions, is used to extrapolate an overall response to treatment is proposed, which is largely validated by the Response Evaluation Criteria in Solid Tumors Group and integrated into the present guidelines.
Journal ArticleDOI
New guidelines to evaluate the response to treatment in solid tumors
Patrick Therasse,Susan G. Arbuck,Elizabeth Eisenhauer,Jantien Wanders,Richard Kaplan,Larry Rubinstein,Jaap Verweij,Martine Van Glabbeke,Allan T. van Oosterom,Michaele C. Christian,S. Gwyther +10 more
TL;DR: In this article, the authors proposed a model by which a combined assessment of all existing lesions, characterized by target lesions (to be measured) and nontarget lesions, is used to extrapolate an overall response to treatment.
Journal ArticleDOI
WHO Handbook for Reporting Results of Cancer Treatment
TL;DR: "Diagnostic Electron Microscopy volume 3", in summary, will provide histopatholo-gists with access to or an interest in electron microscopy with authoritative treatments of several major areas of tumour and non-tumour application: it will be particularly welcomed by those specializing in neoplasia.
Journal ArticleDOI
WHO Handbook for Reporting Results of Cancer Treatment
TL;DR: The WHO Handbook for Reporting Results of Cancer Treatment as discussed by the authors has been published since 1980 and has been used extensively in cancer treatment. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine: Vol. 38, No. 4, pp. 481-481.
Journal ArticleDOI
Quantification of Myocardial Blood Flow With Ultrasound-Induced Destruction of Microbubbles Administered as a Constant Venous Infusion
TL;DR: MBF can be quantified with myocardial contrast echocardiography during a venous infusion of microbubbles and has potential for measuring tissue perfusion in any organ accessible to ultrasound.
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