Journal ArticleDOI
MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells
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TLDR
The data suggested that miR-21 could promote apoptosis resistance, motility, and invasion in prostate cancer cells and these effects of mi R-21 may be partly due to its regulation of PDCD4, TPM1, and MARCKS.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 2009-06-05. It has received 356 citations till now. The article focuses on the topics: DU145 & Cancer stem cell.read more
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Diet, MicroRNAs and Prostate Cancer
TL;DR: The role of microRNAs in prostate carcinogenesis is reviewed by summarizing the findings from studies on the effect of dietary agents on miRNA expression and function.
Journal ArticleDOI
Pdcd4 repression of lysyl oxidase inhibits hypoxia-induced breast cancer cell invasion
TL;DR: The loss of Pdcd4 early in cancer progression may have an important role in the increased sensitivity of cancer cells to hypoxia through increased LOX activity and concomitant enhanced invasiveness.
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MicroRNA-21 regulates the sensitivity of diffuse large B-cell lymphoma cells to the CHOP chemotherapy regimen.
TL;DR: Results provide evidence that it may be possible to overcome microRNA-based DLBCL drug resistance and demonstrate that miR-21 impacts the PI3K/AKT signaling pathway through the regulation of PTEN, thereby affecting cellular sensitivity to the CHOP chemotherapeutic regimen.
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Cellular and molecular mechanisms of pomegranate juice-induced anti-metastatic effect on prostate cancer cells.
TL;DR: It is shown that, in addition to causing cell death of hormone-refractory prostate cancer cells, PJ also increases cell adhesion and decreases cell migration of the cells that do not die, thereby having the potential to decrease inflammation and its impact on cancer progression.
Journal ArticleDOI
Interaction of the oncogenic miR-21 microRNA and the p53 tumor suppressor pathway
TL;DR: The data suggest that inhibition of miR-21 would be beneficial in apoptosis-inducing cancer therapies directed against p53-deficient tumors.
References
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Journal ArticleDOI
A microRNA expression signature of human solid tumors defines cancer gene targets
Stefano Volinia,George A. Calin,Chang Gong Liu,Stefan Ambs,Amelia Cimmino,Fabio Petrocca,Rosa Visone,Marilena V. Iorio,Claudia Roldo,Manuela Ferracin,Robyn L. Prueitt,Nozumu Yanaihara,Giovanni Lanza,Aldo Scarpa,Andrea Vecchione,Massimo Negrini,Curtis C. Harris,Carlo M. Croce +17 more
TL;DR: The results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes.
Journal ArticleDOI
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
Fanyin Meng,Roger Henson,Hania Wehbe-Janek,Kalpana Ghoshal,Samson T. Jacob,Tushar Patel,Tushar Patel +6 more
TL;DR: Aberrant expression of miR-21 can contribute to HCC growth and spread by modulating PTEN expression and PTEN-dependent pathways involved in mediating phenotypic characteristics of cancer cells such as cell growth, migration, and invasion.
Journal ArticleDOI
MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells.
TL;DR: It is shown that the highly malignant human brain tumor, glioblastoma, strongly over-expresses a specific miRNA, miR-21, which may contribute to the malignant phenotype by blocking expression of critical apoptosis-related genes.
Journal ArticleDOI
MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer.
Irfan A. Asangani,Suhail Ahmed Kabeer Rasheed,D. A. Nikolova,Jörg H. Leupold,Nancy H. Colburn,Stefan Post,Heike Allgayer +6 more
TL;DR: This is the first study to show that Pdcd4 is negatively regulated by miR-21, and the first report to demonstrate that mi R-21 induces invasion/intravasation/metastasis.
Journal ArticleDOI
Specificity of microRNA target selection in translational repression
John G. Doench,Phillip A. Sharp +1 more
TL;DR: The ability of an miRNA to translationally repress a target mRNA is largely dictated by the free energy of binding of the first eight nucleotides in the 5' region of the miRNA, however, G:U wobble base-pairing in this region interferes with activity beyond that predicted on the basis of thermodynamic stability.
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