Journal ArticleDOI
MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells
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TLDR
The data suggested that miR-21 could promote apoptosis resistance, motility, and invasion in prostate cancer cells and these effects of mi R-21 may be partly due to its regulation of PDCD4, TPM1, and MARCKS.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 2009-06-05. It has received 356 citations till now. The article focuses on the topics: DU145 & Cancer stem cell.read more
Citations
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Journal ArticleDOI
Polymeric vector-mediated delivery of an miR-21 inhibitor for prostate cancer treatment
Chuyi Chen,Xinghua Huang,Yong Wang,Liteng Lin,Lei Liu,Guanyi Li,Shangchao Wu,Chaozhang Xu,Jianhua Zhou,Xintao Shuai +9 more
TL;DR: The potential of the novel nucleic acid nanomedicine for the effective treatment of prostate cancer is demonstrated through the transfection efficiency and mechanism of action of the PEG–PAsp(DETA)/miR-21 inhibitor towards prostate cancer PC-3 cells.
Journal ArticleDOI
miRNA in Molecular Diagnostics
TL;DR: In this review, miRNAs biogenesis, significance in cancer and infectious diseases, and current available test and methods for their detection are summarized.
DissertationDOI
A novel oncogenic axis involving the ETS factor ESE3/EHF, miR-424, COP1 and STAT3 drives prostate tumor progression
TL;DR: Monitoring the state of miR-424/COP1/STAT3 oncogenic axis could provide new insights for the development of specific therapeutic strategies and the identification of patients more likely to have aggressive tumor and disease recurrence.
BookDOI
MicroRNAs in Development
TL;DR: Digoxygenin-labeled locked nucleic acid oligos have been used to bind strongly and specifically to miR targets and make the identification of the precise spatiotemporal expression of these molecules possible.
Book ChapterDOI
MicroRNAs in Brain Tumors
TL;DR: This chapter reviews the role of specific miRNAs in malignant gliomas and childhood embryonal tumors – medulloblastoma and primitive neuroectodermal brain tumors, in which mi RNAs have been most extensively investigated.
References
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Journal ArticleDOI
A microRNA expression signature of human solid tumors defines cancer gene targets
Stefano Volinia,George A. Calin,Chang Gong Liu,Stefan Ambs,Amelia Cimmino,Fabio Petrocca,Rosa Visone,Marilena V. Iorio,Claudia Roldo,Manuela Ferracin,Robyn L. Prueitt,Nozumu Yanaihara,Giovanni Lanza,Aldo Scarpa,Andrea Vecchione,Massimo Negrini,Curtis C. Harris,Carlo M. Croce +17 more
TL;DR: The results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes.
Journal ArticleDOI
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
Fanyin Meng,Roger Henson,Hania Wehbe-Janek,Kalpana Ghoshal,Samson T. Jacob,Tushar Patel,Tushar Patel +6 more
TL;DR: Aberrant expression of miR-21 can contribute to HCC growth and spread by modulating PTEN expression and PTEN-dependent pathways involved in mediating phenotypic characteristics of cancer cells such as cell growth, migration, and invasion.
Journal ArticleDOI
MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells.
TL;DR: It is shown that the highly malignant human brain tumor, glioblastoma, strongly over-expresses a specific miRNA, miR-21, which may contribute to the malignant phenotype by blocking expression of critical apoptosis-related genes.
Journal ArticleDOI
MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer.
Irfan A. Asangani,Suhail Ahmed Kabeer Rasheed,D. A. Nikolova,Jörg H. Leupold,Nancy H. Colburn,Stefan Post,Heike Allgayer +6 more
TL;DR: This is the first study to show that Pdcd4 is negatively regulated by miR-21, and the first report to demonstrate that mi R-21 induces invasion/intravasation/metastasis.
Journal ArticleDOI
Specificity of microRNA target selection in translational repression
John G. Doench,Phillip A. Sharp +1 more
TL;DR: The ability of an miRNA to translationally repress a target mRNA is largely dictated by the free energy of binding of the first eight nucleotides in the 5' region of the miRNA, however, G:U wobble base-pairing in this region interferes with activity beyond that predicted on the basis of thermodynamic stability.
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Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more