Journal ArticleDOI
MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells
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TLDR
The data suggested that miR-21 could promote apoptosis resistance, motility, and invasion in prostate cancer cells and these effects of mi R-21 may be partly due to its regulation of PDCD4, TPM1, and MARCKS.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 2009-06-05. It has received 356 citations till now. The article focuses on the topics: DU145 & Cancer stem cell.read more
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MicroRNAs in cancer.
TL;DR: In this paper, the effects of miRNA dysregulation in the cellular pathways that lead to the progressive conversion of normal cells into cancer cells and the potential to develop new molecular miRNA-targeted therapies are discussed.
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MicroRNAs in development and disease.
Danish Sayed,Maha Abdellatif +1 more
TL;DR: The discovery, structure, and mode of function of miRNAs in mammalian cells are described, before elaborating on their roles and significance during development and pathogenesis in the various mammalian organs, while attempting to reconcile their functions with the existing knowledge of their targets.
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OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma
TL;DR: It is shown that overexpression of miR-21 leads to a pre-B malignant lymphoid-like phenotype, demonstrating that mir-21 is a genuine oncogene and demonstrating efforts to treat human cancers through pharmacological inactivation of miRNAs such as miR -21.
Journal ArticleDOI
Regulation and function of miRNA-21 in health and disease
TL;DR: Due to the critical functions of its target proteins in various signaling pathways, miR-21 has become an attractive target for genetic and pharmacological modulation in various disease conditions.
Journal ArticleDOI
MicroRNA in prostate, bladder, and kidney cancer: a systematic review.
James W.F. Catto,Antonio Alcaraz,Anders Bjartell,Ralph W deVere White,Christopher P. Evans,Susanne Füssel,Freddie C. Hamdy,Olli Kallioniemi,Lourdes Mengual,Thorsten Schlomm,Tapio Visakorpi +10 more
TL;DR: MiRNAs appear to be important modulators of urologic cancer, and many are functionally implicated in their pathogenesis.
References
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Journal ArticleDOI
miR-21-mediated tumor growth
TL;DR: The results suggest that miR-21 functions as an oncogene and modulates tumorigenesis through regulation of genes such as bcl-2 and thus, it may serve as a novel therapeutic target.
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Programmed Cell Death 4 (PDCD4) Is an Important Functional Target of the MicroRNA miR-21 in Breast Cancer Cells
Lisa B. Frankel,Nanna R. Christoffersen,Anders Jacobsen,Morten Lindow,Anders Krogh,Anders H. Lund +5 more
TL;DR: The tumor suppressor protein Programmed Cell Death 4 (PDCD4) is regulated by miR-21 and it is demonstrated that PDCD4 is a functionally important target for mi R-21 in breast cancer cells.
Journal ArticleDOI
miR‐21: a small multi‐faceted RNA
TL;DR: The aim of this study was to identify miR‐21 as a diagnostic and prognostic marker and potential therapeutic target for gliomas and investigate the mechanisms of elevation in cancer.
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MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators
Galina Gabriely,Thomas Wurdinger,Santosh Kesari,Christine Esau,Julja Burchard,Peter S. Linsley,Anna M. Krichevsky +6 more
TL;DR: It is demonstrated that miR-21 regulates multiple genes associated with glioma cell apoptosis, migration, and invasiveness, including the RECK and TIMP3 genes, which are suppressors of malignancy and inhibitors of matrix metalloproteinases (MMPs).
Journal ArticleDOI
GAP43, MARCKS, and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism.
TL;DR: It is suggested that GAP43, myristoylated alanine-rich C kinase substrate, and CAP23 are functionally and mechanistically related PI(4,5)P2 modulating proteins, upstream of actin and cell cortex dynamics regulation.
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