Journal ArticleDOI
MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells
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TLDR
The data suggested that miR-21 could promote apoptosis resistance, motility, and invasion in prostate cancer cells and these effects of mi R-21 may be partly due to its regulation of PDCD4, TPM1, and MARCKS.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 2009-06-05. It has received 356 citations till now. The article focuses on the topics: DU145 & Cancer stem cell.read more
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Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling.
Poyil Pratheeshkumar,Young-Ok Son,Sasidharan Padmaja Divya,Lilia Turcios,Ram Vinod Roy,John Andrew Hitron,Lei Wang,Donghern Kim,Jin Dai,Padmaja Asha,Zhuo Zhang,Xianglin Shi +11 more
TL;DR: Results demonstrate that the miR-21-PDCD4 signaling axis plays an important role in Cr(VI)-induced carcinogenesis and reduces the tumorogenicity of chronic Cr( VI)-exposed BEAS-2B cells in nude mice.
Journal ArticleDOI
MicroRNA-744 promotes prostate cancer progression through aberrantly activating Wnt/β-catenin signaling.
Han Guan,Chunhui Liu,Fang Fang,Yeqing Huang,Tao Tao,Zhixin Ling,Zonghao You,Xu Han,Shuqiu Chen,Bin Xu,Ming Chen +10 more
TL;DR: The findings indicate that miR-744 acts as one of oncogenic factor in the progression of CRPC by recruiting a mechanism of aberrant activation of Wnt/β-catenin signaling.
Journal ArticleDOI
X MARCKS the spot: myristoylated alanine-rich C kinase substrate in neuronal function and disease.
Jon Brudvig,Jill M. Weimer +1 more
TL;DR: MARCKS has been found to interact with a number of other proteins involved in processes ranging from intracellular signaling to process outgrowth, and their role in an array of brain-specific functions that have important implications for many neurological conditions is explored.
Journal ArticleDOI
Comprehensively Evaluating cis-Regulatory Variation in the Human Prostate Transcriptome by Using Gene-Level Allele-Specific Expression
Nicholas B. Larson,Shannon K. McDonnell,Amy J. French,Zach Fogarty,John C. Cheville,Sumit Middha,Shaun M. Riska,Saurabh Baheti,Asha Nair,Liang Wang,Daniel J. Schaid,Stephen N. Thibodeau +11 more
TL;DR: A comprehensive evaluation of cis-eQTLs by analyzing RNA-seq gene-expression data and genome-wide high-density genotypes from 471 samples of normal primary prostate tissue provides extensive functional context of thousands of SNPs in prostate tissue, and will be of critical value in guiding studies examining disease of the human prostate.
Journal ArticleDOI
miR-584 mediates post-transcriptional expression of lactoferrin receptor in Caco-2 cells and in mouse small intestine during the perinatal period.
Yalin Liao,Bo Lönnerdal +1 more
TL;DR: It is proposed that miR-584 contributes to the post-transcriptional expression of lactoferrin receptor during the perinatal period, a novel example of how microRNAs may be involved in regulation of nutrient metabolism in the newborn.
References
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Journal ArticleDOI
A microRNA expression signature of human solid tumors defines cancer gene targets
Stefano Volinia,George A. Calin,Chang Gong Liu,Stefan Ambs,Amelia Cimmino,Fabio Petrocca,Rosa Visone,Marilena V. Iorio,Claudia Roldo,Manuela Ferracin,Robyn L. Prueitt,Nozumu Yanaihara,Giovanni Lanza,Aldo Scarpa,Andrea Vecchione,Massimo Negrini,Curtis C. Harris,Carlo M. Croce +17 more
TL;DR: The results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes.
Journal ArticleDOI
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
Fanyin Meng,Roger Henson,Hania Wehbe-Janek,Kalpana Ghoshal,Samson T. Jacob,Tushar Patel,Tushar Patel +6 more
TL;DR: Aberrant expression of miR-21 can contribute to HCC growth and spread by modulating PTEN expression and PTEN-dependent pathways involved in mediating phenotypic characteristics of cancer cells such as cell growth, migration, and invasion.
Journal ArticleDOI
MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells.
TL;DR: It is shown that the highly malignant human brain tumor, glioblastoma, strongly over-expresses a specific miRNA, miR-21, which may contribute to the malignant phenotype by blocking expression of critical apoptosis-related genes.
Journal ArticleDOI
MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer.
Irfan A. Asangani,Suhail Ahmed Kabeer Rasheed,D. A. Nikolova,Jörg H. Leupold,Nancy H. Colburn,Stefan Post,Heike Allgayer +6 more
TL;DR: This is the first study to show that Pdcd4 is negatively regulated by miR-21, and the first report to demonstrate that mi R-21 induces invasion/intravasation/metastasis.
Journal ArticleDOI
Specificity of microRNA target selection in translational repression
John G. Doench,Phillip A. Sharp +1 more
TL;DR: The ability of an miRNA to translationally repress a target mRNA is largely dictated by the free energy of binding of the first eight nucleotides in the 5' region of the miRNA, however, G:U wobble base-pairing in this region interferes with activity beyond that predicted on the basis of thermodynamic stability.
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