miR-144 attenuates the host response to influenza virus by targeting the TRAF6-IRF7 signaling axis
Carrie M. Rosenberger,Rebecca L. Podyminogin,Alan H. Diercks,Piper M. Treuting,Jacques J. Peschon,David Rodriguez,Madhumati Gundapuneni,Mitchell J. Weiss,Alan Aderem +8 more
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It is suggested that miR-144 reduces the antiviral response by attenuating the TRAF6-IRF7 pathway to alter the cellular antiviral transcriptional landscape.Abstract:
Antiviral responses must rapidly defend against infection while minimizing inflammatory damage, but the mechanisms that regulate the magnitude of response within an infected cell are not well understood. miRNAs are small non-coding RNAs that suppress protein levels by binding target sequences on their cognate mRNA. Here, we identify miR-144 as a negative regulator of the host antiviral response. Ectopic expression of miR-144 resulted in increased replication of three RNA viruses in primary mouse lung epithelial cells: influenza virus, EMCV, and VSV. We identified the transcriptional network regulated by miR-144 and demonstrate that miR-144 post-transcriptionally suppresses TRAF6 levels. In vivo ablation of miR-144 reduced influenza virus replication in the lung and disease severity. These data suggest that miR-144 reduces the antiviral response by attenuating the TRAF6-IRF7 pathway to alter the cellular antiviral transcriptional landscape.read more
Citations
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MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: In this article, a review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
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On the Importance of Host MicroRNAs During Viral Infection.
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TL;DR: An overview of the current research on miRNAs in allergic diseases, including atopic dermatitis, allergic rhinitis, and asthma is given and how individual miRNas function in the regulation of immune responses in epithelial cells and specialized immune cells in response to different environmental factors and respiratory viruses is discussed.
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Exosome-delivered and Y RNA-derived small RNA suppresses influenza virus replication
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TL;DR: A critical role of Y-class small RNA is unraveled in host’s defense against influenza virus infection and its antiviral mechanism through exosome delivery is revealed, which may provide a new candidate for targeting influenza virus.
References
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Deletion of Irf3 and Irf7 Genes in Mice Results in Altered Interferon Pathway Activation and Granulocyte-Dominated Inflammatory Responses to Influenza A Infection
Bastian Hatesuer,Hang Thi Thu Hoang,Peggy Riese,Stephanie Trittel,Ingo Gerhauser,Husni Elbahesh,Robert Geffers,Esther Wilk,Klaus Schughart,Klaus Schughart +9 more
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Effect of avian influenza A H5N1 infection on the expression of microRNA-141 in human respiratory epithelial cells.
Wai-Yip Lam,Apple C.M. Yeung,Karry Lei-Ka Ngai,Man-Shan Li,Ka Fai To,Stephen Kwok-Wing Tsui,Paul K.S. Chan +6 more
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The IFN regulatory factor 7‐dependent type I IFN response is not essential for early resistance against murine cytomegalovirus infection
Christian Steinberg,Katharina Eisenächer,Olaf Gross,Wolfgang Reindl,Frank Schmitz,Jürgen Ruland,Anne Krug +6 more
TL;DR: IRF7‐dependent antiviral immune responses were not essential for resistance against acute MCMV infection in vivo, and NK cell cytotoxicity was unimpaired andNK cell IFN‐γ production was enhanced in IRf7‐deficient mice correlating with increased levels of bioactive IL‐12.
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Characterization of innate responses to influenza virus infection in a novel lung type I epithelial cell model.
Carrie M. Rosenberger,Rebecca L. Podyminogin,Peter S. Askovich,Garnet Navarro,Shari M. Kaiser,Catherine J. Sanders,Jennifer L. McClaren,Vincent C. Tam,Pradyot Dash,Jhoanna G. Noonan,Bart G. Jones,Sherri L. Surman,Jacques J. Peschon,Alan H. Diercks,Julia L. Hurwitz,Peter C. Doherty,Paul G. Thomas,Alan Aderem +17 more
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