miR-144 attenuates the host response to influenza virus by targeting the TRAF6-IRF7 signaling axis
Carrie M. Rosenberger,Rebecca L. Podyminogin,Alan H. Diercks,Piper M. Treuting,Jacques J. Peschon,David Rodriguez,Madhumati Gundapuneni,Mitchell J. Weiss,Alan Aderem +8 more
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TLDR
It is suggested that miR-144 reduces the antiviral response by attenuating the TRAF6-IRF7 pathway to alter the cellular antiviral transcriptional landscape.Abstract:
Antiviral responses must rapidly defend against infection while minimizing inflammatory damage, but the mechanisms that regulate the magnitude of response within an infected cell are not well understood. miRNAs are small non-coding RNAs that suppress protein levels by binding target sequences on their cognate mRNA. Here, we identify miR-144 as a negative regulator of the host antiviral response. Ectopic expression of miR-144 resulted in increased replication of three RNA viruses in primary mouse lung epithelial cells: influenza virus, EMCV, and VSV. We identified the transcriptional network regulated by miR-144 and demonstrate that miR-144 post-transcriptionally suppresses TRAF6 levels. In vivo ablation of miR-144 reduced influenza virus replication in the lung and disease severity. These data suggest that miR-144 reduces the antiviral response by attenuating the TRAF6-IRF7 pathway to alter the cellular antiviral transcriptional landscape.read more
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MicroRNA-144-3p inhibits autophagy activation and enhances Bacillus Calmette-Guérin infection by targeting ATG4a in RAW264.7 macrophage cells.
Le Guo,Linlin Zhou,Qian Gao,Aijun Zhang,Jun Wei,Dantong Hong,Yuankui Chu,Xiangguo Duan,Ying Zhang,Guangxian Xu +9 more
TL;DR: A novel role of miR-144-3p is revealed in inhibiting autophagy activation by targeting ATG4a and enhancing BCG infection, and provide potential targets for developing improved treatment.
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miR-144-mediated Inhibition of ROCK1 Protects against LPS-induced Lung Endothelial Hyperpermeability.
M. Rizwan Siddiqui,Suhail Akhtar,Mohd Shahid,Mohammad Tauseef,Kelli McDonough,Thomas P. Shanley +5 more
TL;DR: Analysis of miR-144 mediated mechanism in the protection of endothelial barrier function in LPS-induced lung injury model suggests that attenuated activation of inflammatory ROCK1/MLC pathway in vascular EC is a promising therapeutic strategy to counter inflammatory lung injury.
Journal ArticleDOI
Up-regulation of microRNA-203 in influenza A virus infection inhibits viral replication by targeting DR1.
Sen Zhang,Jing Li,Junfeng Li,Yinhui Yang,Xiaoping Kang,Li Yuchang,Wu Xiaoyan,Qingyu Zhu,Yusen Zhou,Yi Hu +9 more
TL;DR: The data show that host cell expression of miR-203 is up-regulated upon IAV infection, which increases antiviral responses by suppressing a novel target gene, DR1.
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Host microRNAs and exosomes that modulate influenza virus infection
TL;DR: This review provides a comprehensive summary of the information available regarding host miRNAs and exosomes that are involved in the modulation of influenza virus infection and will facilitate the development of preventative or therapeutic strategies against influenza virus.
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MiR-590-3p Attenuates Acute Kidney Injury by Inhibiting Tumor Necrosis Factor Receptor-Associated Factor 6 in Septic Mice
TL;DR: In vitro, a miR-590-3p gain-of-function mutation blocked LPS-induced podocyte growth inhibition and apoptosis, as well as overactivation of the inflammatory response, which might provide a novel strategy for the treatment of L PS-induced renal injuries.
References
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TL;DR: The current understanding of miRNA target recognition in animals is outlined and the widespread impact of miRNAs on both the expression and evolution of protein-coding genes is discussed.
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NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
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