miR-144 attenuates the host response to influenza virus by targeting the TRAF6-IRF7 signaling axis
Carrie M. Rosenberger,Rebecca L. Podyminogin,Alan H. Diercks,Piper M. Treuting,Jacques J. Peschon,David Rodriguez,Madhumati Gundapuneni,Mitchell J. Weiss,Alan Aderem +8 more
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TLDR
It is suggested that miR-144 reduces the antiviral response by attenuating the TRAF6-IRF7 pathway to alter the cellular antiviral transcriptional landscape.Abstract:
Antiviral responses must rapidly defend against infection while minimizing inflammatory damage, but the mechanisms that regulate the magnitude of response within an infected cell are not well understood. miRNAs are small non-coding RNAs that suppress protein levels by binding target sequences on their cognate mRNA. Here, we identify miR-144 as a negative regulator of the host antiviral response. Ectopic expression of miR-144 resulted in increased replication of three RNA viruses in primary mouse lung epithelial cells: influenza virus, EMCV, and VSV. We identified the transcriptional network regulated by miR-144 and demonstrate that miR-144 post-transcriptionally suppresses TRAF6 levels. In vivo ablation of miR-144 reduced influenza virus replication in the lung and disease severity. These data suggest that miR-144 reduces the antiviral response by attenuating the TRAF6-IRF7 pathway to alter the cellular antiviral transcriptional landscape.read more
Citations
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MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: In this article, a review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
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On the Importance of Host MicroRNAs During Viral Infection.
TL;DR: This review article describes current techniques that can be used to identify miRNAs involved in the modulation of viral infection and to characterize their targets and mode of action, and presents different reported examples of miRNA-mediated regulation of viruses, which can have a positive outcome either for the host or for the virus.
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Julie Weidner,Sabine Bartel,Ayşe Kılıç,Ulrich M. Zissler,Harald Renz,Jürgen Schwarze,Carsten B. Schmidt-Weber,Tania Maes,Ana Rebane,Susanne Krauss-Etschmann,Madeleine Rådinger +10 more
TL;DR: An overview of the current research on miRNAs in allergic diseases, including atopic dermatitis, allergic rhinitis, and asthma is given and how individual miRNas function in the regulation of immune responses in epithelial cells and specialized immune cells in response to different environmental factors and respiratory viruses is discussed.
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Exosome-delivered and Y RNA-derived small RNA suppresses influenza virus replication
Yuag-Meng Liu,Chung-Hsin Tseng,Yi-Chun Chen,Wen-Ya Yu,Meng-Yen Ho,Chia-Yin Ho,Michael M. C. Lai,Wen-Chi Su +7 more
TL;DR: A critical role of Y-class small RNA is unraveled in host’s defense against influenza virus infection and its antiviral mechanism through exosome delivery is revealed, which may provide a new candidate for targeting influenza virus.
References
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