Mitochondrial-targeted Signal Transducer and Activator of Transcription 3 (STAT3) Protects against Ischemia-induced Changes in the Electron Transport Chain and the Generation of Reactive Oxygen Species
Karol Szczepanek,Qun Chen,Marta Derecka,Marta Derecka,Fadi N Salloum,Qifang Zhang,Magdalena Szelag,Magdalena Szelag,Joanna Cichy,Rakesh C. Kukreja,Jozef Dulak,Edward J. Lesnefsky,Edward J. Lesnefsky,Andrew C. Larner +13 more
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TLDR
A novel protective mechanism mediated by mitochondrial STAT3 that is independent of its canonical activity as a nuclear transcription factor is suggested.About:
This article is published in Journal of Biological Chemistry.The article was published on 2011-08-26 and is currently open access. It has received 193 citations till now. The article focuses on the topics: Respiratory chain & Cytochrome c.read more
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The JAK-STAT pathway at twenty.
George R. Stark,James E. Darnell +1 more
TL;DR: This initial description of the JAK-STAT pathway led quickly to additional discoveries that type II interferons and many other cytokines signal through similar mechanisms, and it now serves as a paradigm showing how information from protein-protein contacts at the cell surface can be conveyed directly to genes in the nucleus.
Journal ArticleDOI
Molecular Basis of Cardioprotection: Signal Transduction in Ischemic Pre-, Post-, and Remote Conditioning
TL;DR: The present review characterizes the signalTransduction underlying the conditioning phenomena, including their physical and chemical triggers, intracellular signal transduction, and effector mechanisms, notably in the mitochondria, as a highly concerted spatiotemporal program.
Journal ArticleDOI
Redox regulation of mitochondrial function.
Diane E. Handy,Joseph Loscalzo +1 more
TL;DR: This review examines the regulation of cellular ROS, their modes of production and removal, and the redox-sensitive targets that are modified by their flux and the role of mitochondria in modulating these pathways.
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The role of STAT3 in autophagy
Liangkun You,Zhanggui Wang,Hongsen Li,Jiawei Shou,Zhao Jing,Jiansheng Xie,Xinbing Sui,Hongming Pan,Weidong Han +8 more
TL;DR: Understanding the role of STAT3 signaling in the regulation of autophagy may provide insight into the classic autophagic model and also into cancer therapy, especially for the emerging targeted therapy, because a series of targeted agents execute antitumor activities via blockingSTAT3 signaling, which inevitably affects the autophile pathway.
Journal ArticleDOI
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
Longchuan Bai,Haibin Zhou,Renqi Xu,Yujun Zhao,Krishnapriya Chinnaswamy,Donna McEachern,Jianyong Chen,Chao Yie Yang,Zhaomin Liu,Mi Wang,Liu Liu,Hui Jiang,Bo Wen,Praveen Kumar,Jennifer L. Meagher,Duxin Sun,Jeanne A. Stuckey,Shaomeng Wang +17 more
TL;DR: SD-36 achieves complete and long-lasting tumor regression in multiple xenograft mouse models at well-tolerated dose schedules and is a promising cancer therapeutic strategy.
References
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Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings
Richard B. Devereux,Richard B. Devereux,Daniel R. Alonso,Daniel R. Alonso,Elizabeth M. Lutas,Elizabeth M. Lutas,Geoffrey J. Gottlieb,Geoffrey J. Gottlieb,E Campo,E Campo,Irene Sachs,Irene Sachs,Nathaniel Reichek,Nathaniel Reichek +13 more
TL;DR: To determine the accuracy of echocardiographic left ventricular (LV) dimension and mass measurements for detection and quantification of LV hypertrophy, results of blindly read antemortem e chocardiograms were compared with LV mass measurements made at necropsy in 55 patients.
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