Journal ArticleDOI
Molecular diversity of glutamate receptors and implications for brain function.
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TLDR
The molecular and functional diversity of the glutamate receptors is reviewed and their implications for integrative brain function are discussed.Abstract:
The glutamate receptors mediate excitatory neurotransmission in the brain and are important in memory acquisition, learning, and some neurodegenerative disorders. This receptor family is classified in three groups: the N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-kainate, and metabotropic receptors. Recent molecular studies have shown that many receptor subtypes exist in all three groups of the receptors and exhibit heterogeneity in function and expression patterns. This article reviews the molecular and functional diversity of the glutamate receptors and discusses their implications for integrative brain function.read more
Citations
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Differential desensitization of ionotropic non-NMDA receptors having distinct neuronal location and function.
TL;DR: Ionotropic non-NMDA receptors mediating enhancement of NA, 5-HT, ACh, GABA and glutamate release exist on the corresponding nerve terminals, suggesting that the receptors involved do not desensitize.
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Combined administration of PHCCC, a positive allosteric modulator of mGlu4 receptors and ACPT-I, mGlu III receptor agonist evokes antidepressant-like effects in rats.
TL;DR: Results of the studies indicate that a combined administration positive allosteric modulation of mGlu4 receptor and agonists of group III mGLU receptors may be a promising target in the future treatment of depressive disorder.
Journal ArticleDOI
Glutamate AMPA receptors in the fascia dentata of human and kainate rat hippocampal epilepsy
Thomas L. Babb,Gary W. Mathern,João Pereira Leite,James K. Pretorius,Kristin M. Yeoman,Paula A. Kuhlman +5 more
TL;DR: The results suggest that in hippocampal epilepsy AMPA receptor numbers increase throughout the length of the molecular layer dendrites; however the AMPA receptors densities are greater in rough relation to the greatest aberrant mossy fiber presynaptic inputs.
Journal ArticleDOI
Bispalladacycle-Catalyzed Michael Addition of In Situ Formed Azlactones to Enones
TL;DR: The development and further evolution of the first catalytic asymmetric conjugate additions of azlactones as activated amino acid derivatives to enones is described and a unique way is presented to prepare diastereomerically pure bicyclic dipeptides in just two steps from unprotected tertiary α-amino acids.
Journal ArticleDOI
Metabotropic glutamate receptors for Parkinson's disease therapy.
TL;DR: The growing understanding of glutamate receptor crosstalk also raises the possibility of more precise modulation of glutamatergic transmission, which may lead to the development of more effective agents for PD.
References
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Journal ArticleDOI
Heteromeric NMDA receptors: Molecular and functional distinction of subtypes
Hannah Monyer,Rolf Sprengel,Ralf Schoepfer,Anne Herb,Miyoko Higuchi,Hilda Lomelí,Nail Burnashev,Bert Sakmann,Peter H. Seeburg +8 more
TL;DR: Molecular cloning identified three complementary DNA species of rat brain, encoding NMDA receptor subunits NMDAR2A (NR2A), NR2B, and NR2C, which are 55 to 70% ientical in sequence, and these are structurally related, with less than 20% sequence identity, to other excitatory amino acid receptor sub Units.
Journal ArticleDOI
The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System
TL;DR: 'The following abbreviations have been used in the text'; I3-N-uxalyl-L-a,l3diaminu-prupiunic acid; ACPD, Trans-l-aminu-cydupentyl-I,3-dicarbuxylate; AMPA, a aminU-3-hydruxy-5-methyl-isoxazole-4-propionate; AP4, 2-
Journal ArticleDOI
Excitatory amino acid neurotoxicity and neurodegenerative disease
Brian S. Meldrum,John Garthwaite +1 more
TL;DR: In vivo and in vitro studies of the cytotoxicity of amino acids are reviewed and the contribution of such toxicity to acute and chronic neurodegenerative disorders is summarized.
Journal ArticleDOI
Molecular cloning and characterization of the rat NMDA receptor
Koki Moriyoshi,Masayuki Masu,Takahiro Ishii,Ryuichi Shigemoto,Noboru Mizuno,Shigetada Nakanishi +5 more
TL;DR: A complementary DNA encoding the rat NMDA receptor has been cloned and characterized and it has been found that this protein has a significant sequence similarity to the AMPA/kainate receptors.
Journal ArticleDOI
Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition
TL;DR: In neurons expressing certain KA-AMPA receptor subunits, glutamate may trigger calcium-dependent intracellular events by activating non-NMDA receptors.