Journal ArticleDOI
Molecular diversity of glutamate receptors and implications for brain function.
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TLDR
The molecular and functional diversity of the glutamate receptors is reviewed and their implications for integrative brain function are discussed.Abstract:
The glutamate receptors mediate excitatory neurotransmission in the brain and are important in memory acquisition, learning, and some neurodegenerative disorders. This receptor family is classified in three groups: the N-methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-kainate, and metabotropic receptors. Recent molecular studies have shown that many receptor subtypes exist in all three groups of the receptors and exhibit heterogeneity in function and expression patterns. This article reviews the molecular and functional diversity of the glutamate receptors and discusses their implications for integrative brain function.read more
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Group I metabotropic glutamate antagonist reduces acute neuronal degeneration and behavioral deficits after traumatic brain injury in rats.
TL;DR: Data indicate that injury-induced acute activation of mGluR1 receptors contributes to both the cellular pathology and the behavioral morbidity associated with TBI.
Journal ArticleDOI
Reversal of Cocaine-Induced Behavioral Sensitization and Associated Phosphorylation of the NR2B and GluR1 Subunits of the NMDA and AMPA Receptors
TL;DR: Pergolide/ondansetron treatment consistently reversed both the behavioral sensitization and the associated changes in the NMDA and AMPA receptor subunits.
Journal ArticleDOI
Interactions between N-acetylaspartylglutamate and AMPA, kainate, and NMDA binding sites.
TL;DR: The hypothesis that, relative to glutamate, NAAG functions as a specific, low potency agonist at N‐methyl‐d‐aspartate subclass of ionotropic acidic amino acid receptors, but the peptide is not likely to activate directly the kainate or quisqualate subclasses of excitatory ionotropic receptors under physiologic conditions is supported.
Journal ArticleDOI
Selective blockade of mGlu5 metabotropic glutamate receptors protects rat hepatocytes against hypoxic damage.
Marianna Storto,Ugo de Grazia,Thomas Knöpfel,Pier Luigi Canonico,Agata Copani,Plinio Richelmi,Ferdinando Nicoletti,Mariapia Vairetti +7 more
TL;DR: 2‐Methyl‐6‐(2‐phenyl‐1‐ethynyl)‐pyridine (MPEP), a novel, noncompetitive, highly selective mGlu5 receptor antagonist, not only abolished the toxic effect of 1S,3R‐ACPD, but, unexpectedly, was protective by itself against anoxic damage.
Journal ArticleDOI
Molecular identification of NMDA glutamate receptors expressed in bone cells.
Cécile Itzstein,Hervé Cheynel,Brigitte Burt-Pichat,Blandine Merle,Léon Espinosa,Pierre D. Delmas,Chantal Chenu +6 more
TL;DR: It is demonstrated for the first time that osteoblasts and osteoclasts express several NR2 subunits, suggesting a molecular diversity of NMDAR channels similar to what was shown for brain.
References
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Journal ArticleDOI
Heteromeric NMDA receptors: Molecular and functional distinction of subtypes
Hannah Monyer,Rolf Sprengel,Ralf Schoepfer,Anne Herb,Miyoko Higuchi,Hilda Lomelí,Nail Burnashev,Bert Sakmann,Peter H. Seeburg +8 more
TL;DR: Molecular cloning identified three complementary DNA species of rat brain, encoding NMDA receptor subunits NMDAR2A (NR2A), NR2B, and NR2C, which are 55 to 70% ientical in sequence, and these are structurally related, with less than 20% sequence identity, to other excitatory amino acid receptor sub Units.
Journal ArticleDOI
The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System
TL;DR: 'The following abbreviations have been used in the text'; I3-N-uxalyl-L-a,l3diaminu-prupiunic acid; ACPD, Trans-l-aminu-cydupentyl-I,3-dicarbuxylate; AMPA, a aminU-3-hydruxy-5-methyl-isoxazole-4-propionate; AP4, 2-
Journal ArticleDOI
Excitatory amino acid neurotoxicity and neurodegenerative disease
Brian S. Meldrum,John Garthwaite +1 more
TL;DR: In vivo and in vitro studies of the cytotoxicity of amino acids are reviewed and the contribution of such toxicity to acute and chronic neurodegenerative disorders is summarized.
Journal ArticleDOI
Molecular cloning and characterization of the rat NMDA receptor
Koki Moriyoshi,Masayuki Masu,Takahiro Ishii,Ryuichi Shigemoto,Noboru Mizuno,Shigetada Nakanishi +5 more
TL;DR: A complementary DNA encoding the rat NMDA receptor has been cloned and characterized and it has been found that this protein has a significant sequence similarity to the AMPA/kainate receptors.
Journal ArticleDOI
Ca2+ permeability of KA-AMPA--gated glutamate receptor channels depends on subunit composition
TL;DR: In neurons expressing certain KA-AMPA receptor subunits, glutamate may trigger calcium-dependent intracellular events by activating non-NMDA receptors.