Journal ArticleDOI
Molecular identification of duck and quail common cytokine receptor γ chain genes.
Jipseol Jeong,Chang Hwan Lee,Jeongmi Yoo,Phil-Ok Koh,Yong-Hwan Kim,Hong H. Chang,Nong-Hoon Choe,Hyun S. Lillehoj,Wongi Min +8 more
TLDR
This study is the first demonstration of an alternatively spliced γ(c) isoform that lacks a transmembrane domain, and indicates a possibility that avian species, unlike mammals, express two different γ (c) transcripts due to alternative splicing.About:
This article is published in Veterinary Immunology and Immunopathology.The article was published on 2011-03-15. It has received 11 citations till now. The article focuses on the topics: Alternative splicing & Intron.read more
Citations
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Journal ArticleDOI
Involvement of T Cell Immunity in Avian Coccidiosis
TL;DR: Research findings concerning the host immune response induced by avian coccidiosis in the context of T cell immunity are focused on, including expression of T-cell-related cytokines and surface molecules that determine the phenotype of T lymphocytes.
Journal ArticleDOI
Recent progress in host immunity to avian coccidiosis: IL-17 family cytokines as sentinels of the intestinal mucosa.
TL;DR: This review highlights recent progress in IL-17 research in the context of host immunity to avian coccidiosis by highlighting the uniqueness of the innate immune response to Eimeria infection and the discovery of previously uncharacterized host genes and proteins whose expression levels were modulated following parasite infection.
Journal ArticleDOI
The evolution of IL-4 and IL-13 and their receptor subunits.
TL;DR: This review will outline what is known about the origins and evolution of type 2 cytokines and their receptors in vertebrates, taking advantage of the recent advances made in gene identification from the many vertebrate genomes that have now been sequenced.
Book ChapterDOI
Comparative Immunology of Agricultural Birds
TL;DR: The discovery and function of immune genes available for these species are reviewed, and many duck and turkey interferons, cytokines, and chemokines were identified by homology to chicken genes, and allow characterization of immune responses following vaccination or infection.
Journal ArticleDOI
Identification and comparative expression analysis of interleukin 2/15 receptor β chain in chickens infected with E. tenella.
Jipseol Jeong,Woo H. Kim,Jeongmi Yoo,Chang Hwan Lee,Suk Kim,Jae-Hyeon Cho,Hyung-Kwan Jang,Dong Wook Kim,Hyun S. Lillehoj,Wongi Min +9 more
TL;DR: The observations suggest that chIL15 and its receptors, including chIL2/15Rβ, play important roles in mucosal immunity to intestinal intracellular parasites such as Eimeria.
References
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Journal ArticleDOI
Function of alternative splicing.
Stefan Stamm,Shani Ben-Ari,Ilona Rafalska,Yesheng Tang,Zhaiyi Zhang,Debra Toiber,Thangavel Alphonse Thanaraj,Hermona Soreq +7 more
TL;DR: Evidence is now accumulating that alternative splicing coordinates physiologically meaningful changes in protein isoform expression and is a key mechanism to generate the complex proteome of multicellular organisms.
Journal ArticleDOI
New insights into the regulation of T cells by |[gamma]|c family cytokines
TL;DR: This knowledge potentially allows for the therapeutic manipulation of immune responses for the treatment of cancer, autoimmunity, allergic diseases and immunodeficiency, as well as for vaccine development.
Journal ArticleDOI
Cloning of the gamma chain of the human IL-2 receptor
Toshikazu Takeshita,Hironobu Asao,Kiyoshi Ohtani,Naoto Ishii,Satoru Kumaki,Nobuyuki Tanaka,Hiroshi Munakata,Masataka Nakamura,Kazuo Sugamura +8 more
TL;DR: A third subunit, the gamma chain, of the human interleukin-2 receptor (IL-2R) was identified, and a complementary DNA clone encoding this member of the cytokine receptor family was isolated.
Book ChapterDOI
Biology of the interleukin-2 receptor.
TL;DR: In part because IL-2 was first identified as a T-cell growth factor, the major focus of investigation in IL-R2 signaling has been on the mechanism of mitogenic effects in cultured cell lines and the apparent functional redundancy of the A and H regions of IL- 2R beta, and their corresponding downstream pathways, with respect to the proliferative response.
Journal ArticleDOI
The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID.
Kazuo Sugamura,Hironobu Asao,Motonari Kondo,Nobuyuki Tanaka,Naoto Ishii,Kazuyuki Ohbo,Masataka Nakamura,Toshikazu Takeshita +7 more
TL;DR: The molecular identification of the gamma chain brought a grasp of the structures and functions of the cytokine receptor and an in-depth understanding of the cause of human XSCID.