Molecular Remission in PML/RARα-Positive Acute Promyelocytic Leukemia by Combined All-trans Retinoic Acid and Idarubicin (AIDA) Therapy
Franco Mandelli,Daniela Diverio,Giuseppe Avvisati,Anna Luciano,Tiziano Barbui,Carlo Bernasconi,Giorgio Broccia,Cerri R,Michele Falda,Giuseppe Fioritoni,Franco Leoni,Vincenzo Liso,Maria Concetta Petti,Francesco Rodeghiero,Giuseppe Saglio,M. L. Vegna,Giuseppe Visani,Ulrich Jehn,Roel Willemze,Petra Muus,Pier Giuseppe Pelicci,Andrea Biondi,Francesco Lo Coco +22 more
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TLDR
This study indicates that the AIDA protocol is a well-tolerated regimen that induces molecular remission in almost all patients with PML/RARα-positive APL and suggests that a remarkable cure rate can be obtained with this treatment.About:
This article is published in Blood.The article was published on 1997-08-01 and is currently open access. It has received 494 citations till now. The article focuses on the topics: Acute promyelocytic leukemia & Retinoic acid syndrome.read more
Citations
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Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide
Steven L. Soignet,Peter Maslak,Zhugang Wang,Suresh C. Jhanwar,Elizabeth Calleja,Laura J. Dardashti,Diane Corso,Anthony DeBlasio,Janice Gabrilove,David A. Scheinberg,Pier Paolo Pandolfi,Raymond P. Warrell +11 more
TL;DR: Low doses of arsenic trioxide can induce complete remissions in patients with APL who have relapsed and the clinical response is associated with incomplete cytodifferentiation and the induction of apoptosis with caspase activation in leukemic cells.
Journal ArticleDOI
A Minicircuitry Comprised of MicroRNA-223 and Transcription Factors NFI-A and C/EBPα Regulates Human Granulopoiesis
Francesco Fazi,Alessandro Rosa,Alessandro Fatica,Vania Gelmetti,Maria Laura De Marchis,Clara Nervi,Irene Bozzoni +6 more
TL;DR: The data indicate that miR-223 plays a crucial role during granulopoiesis and point to the NFI-A repression as an important molecular pathway mediating gene reprogramming in this cell lineage.
Journal ArticleDOI
Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet
Miguel A. Sanz,David Grimwade,Martin S. Tallman,Bob Löwenberg,Pierre Fenaux,Elihu H. Estey,Tomoki Naoe,Eva Lengfelder,Thomas Büchner,Hartmut Döhner,Alan Kenneth Burnett,Francesco Lo-Coco +11 more
TL;DR: This review contains specific recommendations for the identification and management of most important complications such as the bleeding disorder, APL differentiation syndrome, QT prolongation and other ATRA- and ATO-related toxicities, as well as for molecular assessment of response to treatment.
Journal ArticleDOI
A Randomized Comparison of All Transretinoic Acid (ATRA) Followed by Chemotherapy and ATRA Plus Chemotherapy and the Role of Maintenance Therapy in Newly Diagnosed Acute Promyelocytic Leukemia
Pierre Fenaux,Claude Chastang,Sylvie Chevret,Miguel A. Sanz,Hervé Dombret,Eric Archimbaud,Martin F. Fey,Consuelo Rayon,Françoise Huguet,Jean-Jacques Sotto,Claude Gardin,Pascale Cony Makhoul,Philippe Travade,Eric Solary,Nathalie Fegueux,Dominique Bordessoule,Jesús F. San Miguel,Harmut Link,Bernard Desablens,Aspasia Stamatoullas,E. Deconinck,Frédéric Maloisel,Sylvie Castaigne,Claude Preudhomme,Laurent Degos +24 more
TL;DR: It is strongly suggest that early addition of chemotherapy to ATRA and maintenance therapy combining continuous CT and intermittent ATRA can reduce the incidence of relapse in APL.
Journal ArticleDOI
Drug therapy for acute myeloid leukemia.
Martin S. Tallman,Martin S. Tallman,Martin S. Tallman,D. Gary Gilliland,D. Gary Gilliland,D. Gary Gilliland,Jacob M. Rowe,Jacob M. Rowe,Jacob M. Rowe +8 more
TL;DR: In insights into the molecular pathogenesis of AML have led to the development of more specific targeted agents and have ushered in an exciting new era of antileukemia therapy.
References
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Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
TL;DR: A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described, providing a pure preparation of undegraded RNA in high yield and can be completed within 4 h.
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Proposed Revised Criteria for the Classification of Acute Myeloid Leukemia: A Report of the French-American-British Cooperative Group
John M. Bennett,Daniel Catovsky,Marie T. Daniel,George Flandrin,David A. G. Galton,Harvey R. Gralnick,C. Sultan +6 more
TL;DR: The first proposals for the morphologic classification of the acute leukemias by the French-American-British (FAB) group were put forward in the hope that they might serve as a basis for future studies.
Journal ArticleDOI
Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia
TL;DR: All-trans retinoic acid is an effective inducer for attaining complete remission in APL and no abnormalities in the coagulation parameters were measured, suggesting an absence of any subclinical disseminated intravascular coagulations.
Journal ArticleDOI
Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid).
Raymond P. Warrell,Stanley R. Frankel,Wilson H. Miller,David A. Scheinberg,Loretta M. Itri,Walter N. Hittelman,Rohini Vyas,Michael Andreeff,Agostino Tafuri,Ann A. Jakubowski,Janice Gabrilove,Michael Gordon,Ethan Dmitrovsky +12 more
TL;DR: Tretinoin is a safe and highly effective agent for inducing complete remission in patients with acute promyelocytic leukemia and clinical response to this agent is associated with leukemic-cell differentiation and is linked to the expression of an aberrant RAR-alpha nuclear receptor.
Journal ArticleDOI
All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results.
Sylvie Castaigne,Christine Chomienne,Marie Therese Daniel,Paola Ballerini,Roland Berger,Pierre Fenaux,Laurent Degos +6 more
TL;DR: The study confirms the major efficacy of all-trans RA in M3, even in relapsing patients, and shows that complete remissions were obtained without bone marrow (BM) hypoplasia and by a differentiation process.
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