Journal ArticleDOI
Morphology and cellular-traction of fibroblasts on 2D silk-fibroin hydrogel substrates
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Results suggest that surface-stiffness of SF-hydrogel, rather than nature of surface-ligand, regulates both cellular morphology and cellular traction stresses.Abstract:
Development of clinically amenable bio-implants with silk-fibroin (SF) necessitates characterization of cellular-traction generated between cells and the substrate. However, studies on the biomecha...read more
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Bioinspired silk fibroin materials: From silk building blocks extraction and reconstruction to advanced biomedical applications
TL;DR: Wang et al. as mentioned in this paper describe varied building blocks of silk at different levels used in biomedical field and their effective extraction and reconstruction strategies, and present recent discoveries and research progresses on how these functional regenerated silk fibroin (RSF) biomaterials used in advanced biomedical applications, especially in the fields of cell-material interactions, soft tissue regeneration, and flexible bioelectronic devices.
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Trends in mechanobiology guided tissue engineering and tools to study cell-substrate interactions: a brief review
Guoqing Zhao,Md Abdul Goni +1 more
TL;DR: A review of the effects of mechanosignalling in the field of cellular mechanobiology can be found in this paper , where the authors discuss some of the interesting works wherein specific alteration of the mechanical properties of the substrates would lead to fate determination of stem cells into various differentiated cells such as osteoblasts, adipocytes, tenocytes, cardiomyocytes, and neurons, and how these properties are being utilized for the development of organoids.
References
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Journal ArticleDOI
Materials fabrication from Bombyx mori silk fibroin
Danielle N. Rockwood,Rucsanda C. Preda,Tuna Yucel,Xiaoqin Wang,Michael L. Lovett,David L. Kaplan +5 more
TL;DR: This protocol includes methods to extract silk from B. mori cocoons to fabricate hydrogels, tubes, sponges, composites, fibers, microspheres and thin films, used directly as biomaterials for implants, as scaffolding in tissue engineering and in vitro disease models, as well as for drug delivery.
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Extracellular-matrix tethering regulates stem-cell fate
Britta Trappmann,Julien E. Gautrot,Julien E. Gautrot,John T. Connelly,John T. Connelly,Daniel G. T. Strange,Yuan Li,Michelle L. Oyen,Martien A. Cohen Stuart,Heike Boehm,Heike Boehm,Bojun Li,Viola Vogel,Joachim P. Spatz,Joachim P. Spatz,Fiona M. Watt,Wilhelm T. S. Huck,Wilhelm T. S. Huck +17 more
TL;DR: It is concluded that stem cells exert a mechanical force on collagen fibres and gauge the feedback to make cell-fate decisions, and are regulated by the elastic modulus of PAAm.
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Fibroblast Adaptation and Stiffness Matching to Soft Elastic Substrates
TL;DR: Within a range of stiffness spanning that of soft tissues, fibroblasts tune their internal stiffness to match that of their substrate, and modulation of cellular stiffness by the rigidity of the environment may be a mechanism used to direct cell migration and wound repair.
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Soft biological materials and their impact on cell function
TL;DR: Biocompatible synthetic materials already have many applications, but combining chemical compatibility with physiologically appropriate mechanical properties will increase their potential for use both as implants and as substrates for tissue engineering.
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Mechanical control of tissue and organ development
TL;DR: Work based on the convergence of physics, engineering and biology that suggests that mechanical forces generated by living cells are as crucial as genes and chemical signals for the control of embryological development, morphogenesis and tissue patterning is reviewed.