Journal ArticleDOI
Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice.
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TLDR
It is suggested that mPP modulates food intake and the Y4 receptor in the brain may contribute to the regulation of feeding, whereas appearing not to influence anxiety in mice.About:
This article is published in Peptides.The article was published on 1999-12-01. It has received 123 citations till now. The article focuses on the topics: Elevated plus maze & Pancreatic polypeptide.read more
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Journal ArticleDOI
The neurobiology and control of anxious states
TL;DR: The present article focuses in particular upon the multifarious and complex roles of individual modulators, often as a function of the specific receptor type and neuronal substrate involved in their actions; novel targets for the management of anxiety disorders; the influence of neurotransmitters and other agents upon performance in the VCT; data acquired from complementary pharmacological and genetic strategies and, finally, several open questions likely to orientate future experimental- and clinical-research.
Journal ArticleDOI
The NPY system in stress, anxiety and depression.
TL;DR: Information is provided on several brain structures involved in mediating anti-stress actions of NPY, with the most extensive evidence available for amygdala and hippocampus, and some evidence for regions within the septum, and locus coeruleus.
Journal ArticleDOI
Hormonal Regulation of Food Intake
TL;DR: The peripheral hormones and central neuronal pathways that contribute to control of appetite and food intake and energy expenditure are discussed.
Journal ArticleDOI
Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis.
TL;DR: The findings underscore the important role of the NPY-Y receptor system at several levels of the gut–brain axis in which NPY, PYY and PP operate both as neural and endocrine messengers.
Journal ArticleDOI
Characterization of the effects of pancreatic polypeptide in the regulation of energy balance.
Akihiro Asakawa,Akio Inui,Hideki Yuzuriha,Naohiko Ueno,Goro Katsuura,Mineko Fujimiya,Masayuki A. Fujino,Akira Niijima,Michael M. Meguid,Michael M. Meguid,Masato Kasuga +10 more
TL;DR: Observations indicate that PP may influence food intake, energy metabolism, and the expression of hypothalamic peptides and gastric ghrelin.
References
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Journal ArticleDOI
Neuropeptide y and human pancreatic polypeptide stimulate feeding behavior in rats
TL;DR: Findings imply that neuropeptide Y, or a closely related pancreatic polypeptides-like neuropePTide, plays an important role in neural regulation of feeding behavior.
Journal ArticleDOI
Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior.
B G Stanley,S F Leibowitz +1 more
TL;DR: The powerful stimulation of feeding elicited by this neuropeptide suggests an important role for hypothalamic NPY, or a structurally related peptide, in the regulation of feeding behavior.
Journal ArticleDOI
Isolation and characterization of a new pancreatic polypeptide hormone.
JR Kimmel,LJ Hayden,HG Pollock +2 more
TL;DR: The method involves acid-alcohol extraction, gel filtration, DEAE-cellulose chromatography, and droplet countercurrent distribution for isolation of an avian pancreatic polypeptide which may be a new hormone.
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Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY.
TL;DR: Y4 mRNA was detected by reverse transcriptase-polymerase chain reaction in human brain, coronary artery, and ileum, suggesting potential roles for Y4 receptors in central nervous system, cardiovascular, and gastrointestinal function.
Journal ArticleDOI
Feeding and body-weight regulation by hypothalamic neuropeptides—mediation of the actions of leptin
TL;DR: The neuropeptide Y orexigenic network is a final common pathway for this signaling cascade and, along with feeding-inhibitory neuropePTides such as melanocortin, corticotropin-releasing factor and glucagon-like peptide 1, is a major target through which leptin exerts a regulatory tonic restraint on body adiposity.