Journal ArticleDOI
Mucins in cancer: Protection and control of the cell surface
TLDR
Mucins — large extracellular proteins that are heavily glycosylated with complex oligosaccharides — establish a selective molecular barrier at the epithelial surface and engage in morphogenetic signal transduction.Abstract:
Mucins — large extracellular proteins that are heavily glycosylated with complex oligosaccharides — establish a selective molecular barrier at the epithelial surface and engage in morphogenetic signal transduction. Alterations in mucin expression or glycosylation accompany the development of cancer and influence cellular growth, differentiation, transformation, adhesion, invasion and immune surveillance. Mucins are used as diagnostic markers in cancer, and are under investigation as therapeutic targets for cancer.read more
Citations
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Hyaluronan: from extracellular glue to pericellular cue
TL;DR: This work highlights a key role for interactions between hyaluronan and tumour cells in several aspects of malignancy and indicates the possibility of new therapeutic strategies.
Journal ArticleDOI
Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System
Baohui Chen,Luke A. Gilbert,Beth A. Cimini,Joerg Schnitzbauer,Wei Zhang,Gene-Wei Li,Jason Park,Elizabeth H. Blackburn,Jonathan S. Weissman,Lei S. Qi,Bo Huang +10 more
TL;DR: Using an EGFP-tagged endonuclease-deficient Cas9 protein and a structurally optimized small guide (sg) RNA, robust imaging of repetitive elements in telomeres and coding genes in living cells is demonstrated by repurposing the bacterial CRISPR/Cas system.
Journal ArticleDOI
Glycans in cancer and inflammation — potential for therapeutics and diagnostics
TL;DR: This review highlights changes in glycosylation associated with cancer and chronic inflammation and new therapeutic and diagnostic strategies that are based on the underlying glycobiology.
Journal ArticleDOI
Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers.
TL;DR: The protective barrier properties of mucus secretions, how mucus affects the fate of orally administered nanoparticles, and recent developments in nanoparticles engineered to penetrate the mucus barrier are addressed.
Journal ArticleDOI
The sweet and sour of cancer: glycans as novel therapeutic targets.
Mark M. Fuster,Jeffrey D. Esko +1 more
TL;DR: A growing body of evidence supports crucial roles for glycans at various pathophysiological steps of tumour progression, and increased understanding of these roles sets the stage for developing pharmaceutical agents that target these molecules.
References
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Journal ArticleDOI
Reactivity of a monoclonal antibody with human ovarian carcinoma.
TL;DR: A murine monoclonal antibody (OC125) has been developed that reacts with each of six epithelial ovarian carcinoma cell lines and with cryopreserved tumor tissue from 12 of 20 ovarian cancer patients, but does not bind to a variety of nonmalignant tissues, including adult and fetal ovary.
Journal ArticleDOI
Molecular cloning and expression of human Tumor-associated Polymorphic Epithelial Mucin
Sandra Gendler,Carole A. Lancaster,Joyce Taylor-Papadimitriou,Trevor Duhig,Nigel Peat,Joy Burchell,Lucy Pemberton,El-Nasir Lalani,David Wilson +8 more
TL;DR: The full sequence for PEM, as deduced from cDNA sequences, is reported, with length variations in the tandem repeat result in PEM being an expressed variable number tandem repeat locus.
Journal ArticleDOI
Colorectal cancer in mice genetically deficient in the mucin Muc2.
Anna Velcich,Wancai Yang,Joerg Heyer,Alessandra Fragale,Courtney Nicholas,Stephanie Viani,Raju Kucherlapati,Martin Lipkin,Kan Yang,Leonard H. Augenlicht +9 more
TL;DR: Muc2 is involved in the suppression of colorectal cancer and frequently developed adenomas in the small intestine that progressed to invasive adenocarcinoma, as well as rectal tumors.
Journal ArticleDOI
Heparin and cancer revisited: Mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis
TL;DR: Heparin treatment attenuates tumor metastasis in mice by inhibiting P-selectin-mediated interactions of platelets with carcinoma cell-surface mucin ligands, and it is suggested that heparin therapy for metastasis prevention in humans be revisited, with these mechanistic paradigms in mind.
Journal Article
Identification of the gastrointestinal and pancreatic cancer-associated antigen detected by monoclonal antibody 19-9 in the sera of patients as a mucin
TL;DR: Adversity affinity purified by antibody 19-9 from the serum of a cancer patient belonging to the Le(a-b+) blood group contains Leb antigen, consistent with the multiple antigenic specificities exhibited by mucins.