Journal ArticleDOI
Multilayered coating on titanium for controlled release of antimicrobial peptides for the prevention of implant-associated infections
Mehdi Kazemzadeh-Narbat,Benjamin F.L. Lai,Chuanfan Ding,Jayachandran N. Kizhakkedathu,Robert E. W. Hancock,Rizhi Wang +5 more
TLDR
A controlled release of an antimicrobial peptide (AMP) from titanium surface through a non-cytotoxic multilayered coating can be a potential approach to locally deliver AMPs to prevent peri-implant infection in orthopaedics without being toxic to host cells.About:
This article is published in Biomaterials.The article was published on 2013-08-01. It has received 298 citations till now. The article focuses on the topics: Platelet activation & Controlled release.read more
Citations
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Antibacterial Coatings: Challenges, Perspectives, and Opportunities
TL;DR: This work reviews release-based antibacterial coatings and highlights recent approaches aimed at controlling the release of antibacterial agents, imparting multi-functionality, and enhancing long-term stability.
Journal ArticleDOI
Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants.
TL;DR: Recent progress and future directions for the design of multifunctional orthopaedic coatings that can inhibit microbial cells while still promoting osseointegration are discussed.
Journal ArticleDOI
Bio-Inspired Titanium Dioxide Materials with Special Wettability and Their Applications
TL;DR: Their Applications Kesong Liu,†,∥ Moyuan Cao,† Akira Fujishima, and Lei Jiang*,†,‡ †Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry and Environment, Beihang University, Beijing 100191, PR.
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Clinical presentation and treatment of orthopaedic implant-associated infection.
TL;DR: This work has shown that surface coating with antimicrobial peptides that reduce bacterial attachment and biofilm formation can potentially prevent implant‐associated infection and quorum‐sensing inhibitors are a novel therapeutic option against biofilm infections.
Journal ArticleDOI
Antibacterial Surface Treatment for Orthopaedic Implants
TL;DR: There appears to be a great discrepancy between proposed and clinically implemented strategies, and there is urgent need for translational science focusing on this topic.
References
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Journal ArticleDOI
Bacterial biofilms : A common cause of persistent infections
TL;DR: Improvements in understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
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Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TL;DR: In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.
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Antibiotic resistance of bacteria in biofilms
TL;DR: The features of biofilm infections are summarized, the emerging mechanisms of resistance are reviewed, and potential therapies are discussed.
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Ti based biomaterials, the ultimate choice for orthopaedic implants – A review
TL;DR: In this paper, the influence of alloy chemistry, thermomechanical processing and surface condition on these properties is discussed and various surface modification techniques to achieve superior biocompatibility, higher wear and corrosion resistance.
Journal ArticleDOI
How to measure and predict the molar absorption coefficient of a protein.
TL;DR: The studies reported here suggest that the Edelhoch method is the best method for measuring ε for a protein, which can best be predicted with this equation.