[Multimorbidity and successful aging: the population-based KORA-Age study].
Annette Peters,Angela Döring,K.H. Ladwig,Christine Meisinger,Birgit Linkohr,Christine S. Autenrieth,Sebastian E. Baumeister,Juergen Behr,Albrecht Bergner,Horst Bickel,Martin Bidlingmaier,André Dias,Rebecca T. Emeny,Beate Fischer,Eva Grill,Lukas Gorzelniak,H. Hansch,S. Heidbreder,Margit Heier,Alexander Horsch,Dorothea Huber,Rudolf M. Huber,Rudolf A. Jörres,Stefan Kääb,Stefan Karrasch,Inge Kirchberger,Günther Klug,B. Kranz,Bernhard Kuch,Maria Elena Lacruz,O. Lang,Andreas Mielck,Dennis Nowak,Siegfried Perz,Astrid Schneider,Holger Schulz,Martin Müller,Hildegard Seidl,Ralf Strobl,Barbara Thorand,Rupert Wende,Wolfgang Weidenhammer,Anja-Kerstin Zimmermann,Heinz Erich Wichmann,Rolf Holle +44 more
TLDR
The KORA-Age consortium was able to collect data in a large population-based sample and is contributing to the understanding of multimorbidity and successful aging.Abstract:
Background The objective of the KORA-Age research consortium is to assess the determinants and consequences of multimorbidity in the elderly and to look into reasons for successful aging in the general public. Patients and methods In the KORA-Age cohort study 9,197 persons were included who where born in the year 1943 or before and participants of previous KORA cohort studies conducted between 1984 and 2001 (KORA: Cooperative Health Research in the Region of Augsburg). The randomized intervention study KORINNA (Coronary infarct follow-up treatment in the elderly) tested a nurse-based case management program with 338 patients with myocardial infarct and included an evaluation in health economics. Results A total of 2,734 deaths were registered, 4,565 participants submitted a postal health status questionnaire and 4,127 participants were interviewed by telephone (response 76.2% and 68.9% respectively). A gender and age-stratified random sample of the cohort consisting of 1,079 persons took part in a physical examination (response 53.8%). Conclusion The KORA-Age consortium was able to collect data in a large population-based sample and is contributing to the understanding of multimorbidity and successful aging.read more
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The German COPD cohort COSYCONET: Aims, methods and descriptive analysis of the study population at baseline
Annika Karch,Claus Vogelmeier,Tobias Welte,Robert Bals,Hans-Ulrich Kauczor,Jürgen Biederer,Joachim Heinrich,Holger Schulz,Sven Gläser,Rolf Holle,Henrik Watz,Stephanie Korn,Nina Adaskina,Frank Biertz,Charlotte Vogel,Jørgen Vestbo,Emiel F.M. Wouters,Klaus F. Rabe,Sandra Söhler,Armin Koch,Rudolf A. Jörres +20 more
TL;DR: The German COPD cohort comprises patients with advanced and less advanced COPD, and baseline data indicate that COSYCONET offers the opportunity to investigate the research questions in a large-scale, high-quality dataset.
Journal ArticleDOI
Telomere length in circulating leukocytes is associated with lung function and disease
Eva Albrecht,Elina Sillanpää,Stefan Karrasch,Alexessander Couto Alves,Veryan Codd,Veryan Codd,Iiris Hovatta,Iiris Hovatta,Jessica L. Buxton,Christopher P. Nelson,Christopher P. Nelson,Linda Broer,Linda Broer,Sara Hägg,Sara Hägg,Massimo Mangino,Gonneke Willemsen,Ida Surakka,Ida Surakka,Manuel A. R. Ferreira,Najaf Amin,Ben A. Oostra,Hell M. Backmand,Hell M. Backmand,Markku Peltonen,Seppo Sarna,Taina Rantanen,Sarianna Sipilä,Tellervo Korhonen,Pamela A. F. Madden,Christian Gieger,Rudolf A. Jörres,Joachim Heinrich,Juergen Behr,Rudolf M. Huber,Annette Peters,Konstantin Strauch,H.-Erich Wichmann,Melanie Waldenberger,Alexandra I. F. Blakemore,Eco J. C. de Geus,Dale R. Nyholt,Anjali K. Henders,Päivi Piirilä,Aila Rissanen,Patrik K. E. Magnusson,Ana Viñuela,Kirsi H. Pietiläinen,Kirsi H. Pietiläinen,Nicholas G. Martin,Nancy L. Pedersen,Dorret I. Boomsma,Tim D. Spector,Cornelia M. van Duijn,Cornelia M. van Duijn,Jaakko Kaprio,Jaakko Kaprio,Nilesh J. Samani,Nilesh J. Samani,Marjo-Riitta Järvelin,Holger Schulz +60 more
TL;DR: The results provide indirect evidence for the hypothesis that cellular senescence may contribute to the pathogenesis of COPD and asthma, and that lung function may reflect biological ageing primarily due to intrinsic processes, which are likely to be aggravated in lung diseases.
Journal ArticleDOI
How much does it hurt to be lonely? Mental and physical differences between older men and women in the KORA-Age Study.
A Zebhauser,L. Hofmann-Xu,Jens Baumert,S. Häfner,Maria Elena Lacruz,Rebecca T. Emeny,Angela Döring,Eva Grill,Dorothea Huber,Annette Peters,Karl-Heinz Ladwig +10 more
TL;DR: The intensity of and factors associated with loneliness between men and women are compared and sex‐specific differences on the experience of loneliness remain sparse.
Journal ArticleDOI
Direct and indirect costs of COPD and its comorbidities: Results from the German COSYCONET study.
Margarethe Wacker,Rudolf A. Jörres,Hans-Ulrich Schulz,Joachim Heinrich,Stefan Karrasch,Stefan Karrasch,Annika Karch,Armin Koch,Annette Peters,Reiner Leidl,Claus Vogelmeier,Rolf Holle +11 more
TL;DR: COPD is associated with substantially higher costs than previously reported and this study investigates COPD excess healthcare utilization, work absenteeism, and resulting costs within the German COPD cohort COSYCONET.
Journal ArticleDOI
Burden of disability attributable to vertigo and dizziness in the aged: results from the KORA-Age study
TL;DR: In this paper, the authors investigated the specific contribution of vertigo and dizziness to the total burden of disability in aged persons when controlling for the presence of other health conditions, including non-vestibular sensory loss, vascular encephalopathy or anxiety.
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