Journal ArticleDOI
Multiple mechanisms regulate the expression of murine immune response genes
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TLDR
Evidence that A beta 2 is transcribed in spleen and in a cultured B cell hybridoma is presented, suggesting that B cells and macrophages regulate the expression of the class II genes by distinct mechanisms.About:
This article is published in Cell.The article was published on 1985-09-01. It has received 42 citations till now. The article focuses on the topics: Antigen & Major histocompatibility complex.read more
Citations
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Journal ArticleDOI
Mice lacking MHC class II molecules
Dominic Cosgrove,David Gray,Andrée Dierich,James C. Kaufman,Marianne LeMeur,Christophe Benoist,Diane Mathis +6 more
TL;DR: Some old ideas about lymphocyte differentiation have been confirmed, but some surprises are provided: a lack of germinal centers, fewer IgM+IgD+ cells in certain individuals, reduced production of serum IgG1, and complete inability to respond to T-dependent antigens.
Journal ArticleDOI
Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression
TL;DR: CIITA-deficient (-/-) mice do not express conventional MHC class II molecules on the surface of splenic B cells and dendritic cells and are impaired in T-dependent antigen responses and MHCclass II-mediated allogeneic responses.
Journal ArticleDOI
Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells.
David Lo,Linda C. Burkly,Georg Widera,C. Cowing,Richard A. Flavell,Richard D. Palmiter,Ralph L. Brinster +6 more
TL;DR: Novel expression of Class II MHC molecules on nonlymphoid cells is by itself insufficient to initiate autoimmune responses against tissue-specific antigens, and T lymphocytes appeared to be tolerant to the transgene I-Eb molecule.
Journal ArticleDOI
Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing
TL;DR: Expression of HLA-DO in a class II+ and DM+, DO- human T cell line caused the accumulation of class II-CLIP complexes, indicating that Hla-DO blocked DM function in vivo and suggesting that HLA-DO is an important modulator ofclass II-restricted antigen processing.
Journal ArticleDOI
Altered Antigen Presentation in Mice Lacking H2-O
Monika Liljedahl,Ola Winqvist,Charles D. Surh,Phillip Wong,Karen Ngo,Luc Teyton,Per A. Peterson,Anders Brunmark,Alexander Y. Rudensky,Wai-Ping Fung-Leung,Lars Karlsson +10 more
TL;DR: Analysis of antigen presentation by B cells from mice lacking H2-O, together with biochemical analysis using purified HLA-DO and Hla-DM molecules, suggests that HLA’s role in peptide loading may be affected, which may serve to decrease the presentation of antigens internalized by fluid-phase endocytosis, thus concentrating the B cell-mediated antigen presentation to antigeninternalized by membrane immunoglobulin.
References
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Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
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Genomic sequencing
George M. Church,Walter Gilbert +1 more
TL;DR: The genomic sequencing procedures are applicable to the analysis of genetic polymorphisms, DNA methylation at deoxycytidines, and nucleic acid-protein interactions at single nucleotide resolution.
Journal ArticleDOI
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter
TL;DR: In this paper, a simple and efficient method for synthesizing pure single stranded RNAs of virtually any structure is described, based on the unusually specific RNA synthesis by bacteriophage SP6 RNA polymerase which initiates transcription exclusively at an SP6 promoter.
Journal ArticleDOI
Purification of a new neurotrophic factor from mammalian brain.
TL;DR: This factor is the first neurotrophic factor to be purified since NGF, from which it is clearly distinguished because it has different antigenic and functional properties.
Journal ArticleDOI
Identification of two distinct regulatory regions adjacent to the human β-interferon gene
TL;DR: To study the regulation of the human beta-interferon (beta-IFN) gene by poly(I)-poly(C), the expression of deletion mutants of the cloned gene introduced into mouse cells on a new bovine papilloma virus vector is analyzed.
Related Papers (5)
DO beta: a new beta chain gene in HLA-D with a distinct regulation of expression.
C Tonnelle,R DeMars,Eric O. Long +2 more
An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules.
HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading
Lisa K. Denzin,Peter Cresswell +1 more