Journal ArticleDOI
Nanocarriers based oral lymphatic drug targeting: Strategic bioavailability enhancement approaches
TLDR
Various strategies to enhance drug bioavailability through lymphatic targeting are discussed, which can improve the treatment efficacy, survival, and life expectancy of the patient.About:
This article is published in Journal of Drug Delivery Science and Technology.The article was published on 2021-08-01. It has received 16 citations till now. The article focuses on the topics: Nanocarriers & Targeted drug delivery.read more
Citations
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Journal ArticleDOI
Engineering Nano- and Microparticles as Oral Delivery Vehicles to Promote Intestinal Lymphatic Drug Transport.
Yang-Bao Miao,Yu-Jung Lin,Chen Kuan-Hung,Po-Kai Luo,Shun-Hao Chuang,Yu-Tzu Yu,Hsien-Meng Tai,Chiung-Tong Chen,Kun-Ju Lin,Hsing-Wen Sung +9 more
TL;DR: In this paper, the authors describe the anatomical structures and physiological characteristics of the intestinal lymphatic system (ILS), with an emphasis on enterocytes and microfold (M) cells, which are the main gateways for the transport of particulate delivery vehicles across the intestinal epithelium into the lymphatics.
Journal ArticleDOI
Bioavailability enhancement of vitamin E TPGS liposomes of nintedanib esylate: formulation optimization, cytotoxicity and pharmacokinetic studies
TL;DR: Liposomes performed better than marketed capsules upon oral administration because of the prolonged drug release and increased oral bioavailability; as a result, the developed formulation can become a successful strategy in cancer chemotherapy.
Journal ArticleDOI
Ligand-modified nanocarriers for oral drug delivery: Challenges, rational design, and applications.
TL;DR: In this paper , the extracellular and cellular barriers to orally administered nanocarriers in the gastrointestinal (GI) tract and new discoveries regarding the GI protein corona and the sequential transport barriers that impede the preplanned movements of LMNCs after oral administration are discussed.
Journal ArticleDOI
Lymphatic targeting for therapeutic application using nanoparticulate systems
Prashant Kesharwani,Aldric Hama +1 more
TL;DR: A review of the lymphatic system and changes that occur during disease, drug characteristics, and physicochemical parameters that influence lymphatic uptake of drugs and different nanocarriers is presented in this article .
Journal ArticleDOI
Lymphatic targeting for therapeutic application using nanoparticulate systems
TL;DR: The current review focuses on the understanding and pathophysiology of the lymphatic system and changes that occur during disease, drug characteristics, and physicochemical parameters that influence theymphatic uptake of drugs and different nanocarriers.
References
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Journal ArticleDOI
Diagnosis and Classification of Diabetes Mellitus
TL;DR: The chronic hyperglycemia of diabetes is associated with long-term damage, dys-function, and failure of differentorgans, especially the eyes, kidneys, nerves, heart, and blood vessels.
Journal ArticleDOI
Integrins: Bidirectional, Allosteric Signaling Machines
TL;DR: Current structural and cell biological data suggest models for how integrins transmit signals between their extracellular ligand binding adhesion sites and their cytoplasmic domains, which link to the cytoskeleton and to signal transduction pathways.
Journal ArticleDOI
Nano based drug delivery systems: recent developments and future prospects
Jayanta Kumar Patra,Gitishree Das,Leonardo Fernandes Fraceto,Leonardo Fernandes Fraceto,Estefania Vangelie Ramos Campos,Estefania Vangelie Ramos Campos,Maria del Pilar Rodriguez-Torres,Laura Susana Acosta-Torres,Luis A. Diaz-Torres,Renato Grillo,Mallappa Kumara Swamy,Shivesh Sharma,Solomon Habtemariam,Han-Seung Shin +13 more
TL;DR: An updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs and selective diagnosis through disease marker molecules is presented.
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Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers.
TL;DR: The protective barrier properties of mucus secretions, how mucus affects the fate of orally administered nanoparticles, and recent developments in nanoparticles engineered to penetrate the mucus barrier are addressed.
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Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach.
TL;DR: Vaccines are certainly the most promising applications for orally delivered nanoparticles and encouraging results upon in vivo testing are reported but low bioavailability and lack of control on absorbed dose slow down products development.