Nanoparticles for oral delivery: Design, evaluation and state-of-the-art.
TLDR
N nanoparticle design aspects to improve delivery to particular sites in the GI tract are discussed and the state-of-the-art in preclinical targeted nanoparticles design is reviewed.About:
This article is published in Journal of Controlled Release.The article was published on 2016-10-28 and is currently open access. It has received 286 citations till now. The article focuses on the topics: Drug delivery.read more
Citations
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Chitosan and Its Derivatives for Application in Mucoadhesive Drug Delivery Systems
TL;DR: This review has particularly focused on the effect of chemical derivatization on the mucoadhesive properties of chitosan, and other important properties including water-solubility, stability, controlled release, permeation enhancing effect, and in vivo performance are described.
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Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues.
Patrik Lundquist,Per Artursson +1 more
TL;DR: The opportunities and predictivity of various in vitro systems with special emphasis on human intestine in Ussing chambers are discussed, and characteristics of common in vitro cell culture systems are discussed and compared to those of human intestinal tissues.
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Perspectives on the past, present, and future of cancer nanomedicine.
Yu Seok Youn,You Han Bae +1 more
TL;DR: The clinical trials of experimental nanomedicine have experienced unexpected adverse effects with modest improvement in efficacy when compared to current frontline therapy, which can widen the therapeutic window of an anticancer drug of interest.
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Materials for oral delivery of proteins and peptides
TL;DR: Physiological barriers to the oral delivery of protein-based therapies are discussed, along with the current translational landscape and state of the art of materials for oral protein delivery.
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Rapid transport of deformation-tuned nanoparticles across biological hydrogels and cellular barriers
Miaorong Yu,Lu Xu,Falin Tian,Qian Su,Nan Zheng,Yiwei Yang,Jiuling Wang,Aohua Wang,Chunliu Zhu,Shiyan Guo,Xinxin Zhang,Yong Gan,Xinghua Shi,Huajian Gao +13 more
TL;DR: It is demonstrated that (poly(lactic-co-glycolic acid) core)-(lipid shell) NPs with moderate rigidity display enhanced diffusivity through mucus compared with some synthetic mucus penetration particles (MPPs), achieving a mucosal and tumor penetrating capability superior to that of both their soft and hard counterparts.
References
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Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
TL;DR: It is concluded that Caco-2 cells grown on collagen-coated polycarbonate membranes should represent a valuable transport model system for the small intestinal epithelium.
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Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review.
Meera George,T. Emilia Abraham +1 more
TL;DR: Alginate, being an anionic polymer with carboxyl end groups, is a good mucoadhesive agent and cross-linked alginate has more capacity to retain the entrapped drugs and mixing of alginates with other polymers such as neutral gums, chitosan, and eudragit have been found to solve the problem of drug leaching.
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Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues.
TL;DR: The tenacious mucus barrier properties that have precluded the efficient penetration of therapeutic particles are described and the design and development of new mucus-penetrating particles that may avoid rapid mucus clearance mechanisms are reviewed to provide targeted or sustained drug delivery for localized therapies in mucosal tissues.
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From 3D cell culture to organs-on-chips.
TL;DR: New advances in 3D culture that leverage microfabrication technologies from the microchip industry and microfluidics approaches to create cell-culture microen environments that both support tissue differentiation and recapitulate the tissue-tissue interfaces, spatiotemporal chemical gradients, and mechanical microenvironments of living organs are reviewed.
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Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow
Hyun Jung Kim,Dongeun Huh,Geraldine A. Hamilton,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +5 more
TL;DR: This gut-on-a-chip recapitulates multiple dynamic physical and functional features of human intestine that are critical for its function within a controlled microfluidic environment that is amenable for transport, absorption, and toxicity studies, and hence it should have great value for drug testing as well as development of novel intestinal disease models.