Journal ArticleDOI
Near-Infrared Fluorescent Nanomaterials for Bioimaging and Sensing
Philipp Reineck,Brant C. Gibson +1 more
TLDR
In this paper, a review describes recent advances in the development and use of near-infrared fluorescent nanomaterials for biomedical imaging and sensing applications The physical and chemical properties as well as the bioconjugation and application of materials such as organic fluorophores, semiconductor quantum dots, carbon-based materials, rare earth materials and polymer particles are discussed.Abstract:
A great challenge in noninvasive biomedical imaging is the acquisition of images inside a biological system at the cellular level Common modalities used today such as magnetic resonance or computed tomography imaging have the advantage that any part of a living organism can be imaged at any depth, but are limited to millimeter resolution and can usually not be employed eg, for surgical guidance Optical imaging techniques offer resolution on the 100 nanometer scale, but are limited by the strong attenuation of visible light by biological matter and are traditionally used to image on the surface Near-infrared light in the "biological windows" can penetrate much deeper into biological samples, rendering fluorescence-based imaging a viable alternative In the past two decades, many fluorescent nanomaterials have been developed to operate in the near infrared, yet only few materials emitting above 1000 nm exist and none are approved for clinical use This review describes recent advances in the development and use of near-infrared fluorescent nanomaterials for biomedical imaging and sensing applications The physical and chemical properties as well as the bioconjugation and application of materials such as organic fluorophores, semiconductor quantum dots, carbon-based materials, rare earth materials, and polymer particles are discussedread more
Citations
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Journal ArticleDOI
Supramolecular Luminescent Sensors
TL;DR: Specific focus is placed on the development of new macrocycle hosts since 2010, coupled with considerations of the underlying principles of supramolecular chemistry as well as analytes of interest and common luminophores.
Development of a Bioorthogonal and Highly Efficient Conjugation Method for Quantum Dots using Tetrazine-Norbornene Cycloaddition
Hee-Sun Han,Neal K. Devaraj,Jungmin Lee,Scott A. Hilderbrand,Ralph Weissleder,Moungi G. Bawendi +5 more
TL;DR: This work presents a bioorthogonal and modular conjugation method for efficient coupling of organic dyes and biomolecules to quantum dots (QDs) using a norbornene-tetrazine cycloaddition and has applied this method to the in situ targeting of norbornenes-coated QDs to live cancer cells labeled with tetrazine-modified proteins.
Journal ArticleDOI
Peroxynitrite Activatable NIR-II Fluorescent Molecular Probe for Drug-Induced Hepatotoxicity Monitoring.
Dandan Li,Shangfeng Wang,Zuhai Lei,Caixia Sun,Ahmed Mohamed El-Toni,Mansour Alhoshan,Yong Fan,Fan Zhang +7 more
TL;DR: Using this probe, the upregulation of ONOO- is disclosed in a preclinical drug-induced liver injury model and the remediation with N-acetyl cysteine in vivo and it is expected that this strategy will serve as a general method for the development of an activatable NIR-II probe based on the hydroxyl functionalized reactive sites by analyte-specific triggering.
Journal ArticleDOI
Recent Progress in Small-Molecule Near-IR Probes for Bioimaging.
Jun-Bin Li,Hong-Wen Liu,Ting Fu,Ruowen Wang,Xiao-Bing Zhang,Weihong Tan,Weihong Tan,Weihong Tan +7 more
TL;DR: This review focuses on the most recent advances in the development of small-molecule NIR probes and their applications in bioimaging, and highlights the challenges and opportunities in this rapidly developing field.
Journal ArticleDOI
Near infrared quantum dots in biomedical applications: current status and future perspective.
Peng Zhao,Peng Zhao,Quan Xu,Jia Tao,Jia Tao,Zongwen Jin,Yue Pan,Changmin Yu,Zhiqiang Yu,Zhiqiang Yu +9 more
TL;DR: The basic structures and properties of NIR QDs are introduced, and the classification and the related synthetic methods are summarized, and their biomedical applications in biosensing, bioimaging, and drug delivery are highlighted.
References
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Journal ArticleDOI
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