Nervous system involvement after infection with COVID-19 and other coronaviruses
TLDR
The research into neurological complications in CoV infections and the possible mechanisms of damage to the nervous system are reviewed.Abstract:
Viral infections have detrimental impacts on neurological functions, and even to cause severe neurological damage. Very recently, coronaviruses (CoV), especially severe acute respiratory syndrome CoV 2 (SARS-CoV-2), exhibit neurotropic properties and may also cause neurological diseases. It is reported that CoV can be found in the brain or cerebrospinal fluid. The pathobiology of these neuroinvasive viruses is still incompletely known, and it is therefore important to explore the impact of CoV infections on the nervous system. Here, we review the research into neurological complications in CoV infections and the possible mechanisms of damage to the nervous system.read more
Citations
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A longitudinal study on the mental health of general population during the COVID-19 epidemic in China.
Cuiyan Wang,Riyu Pan,Xiaoyang Wan,Yilin Tan,Linkang Xu,Roger S. McIntyre,Faith N. Choo,Bach Xuan Tran,Roger C.M. Ho,Vivek Sharma,Cyrus S.H. Ho +10 more
TL;DR: Governments should focus on effective methods of disseminating unbiased COVID-19 knowledge, teaching correct containment methods, ensuring availability of essential services/commodities, and providing sufficient financial support.
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Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors.
Mario Gennaro Mazza,Rebecca De Lorenzo,Caterina Conte,Sara Poletti,Benedetta Vai,Irene Bollettini,Elisa Melloni,Roberto Furlan,Fabio Ciceri,Patrizia Rovere-Querini,Francesco Benedetti +10 more
TL;DR: It is recommended to assess psychopathology of COVID-19 survivors and to deepen research on inflammatory biomarkers, in order to diagnose and treat emergent psychiatric conditions.
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Postmortem examination of COVID-19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings in lungs and other organs suggesting vascular dysfunction.
Thomas Menter,Jasmin D. Haslbauer,Ronny Nienhold,Spasenija Savic,Helmut Hopfer,Nikolaus Deigendesch,Stephan Frank,Daniel Turek,Niels Willi,Hans Pargger,Stefano Bassetti,Joerg D. Leuppi,Gieri Cathomas,Markus Tolnay,Kirsten D. Mertz,Alexandar Tzankov +15 more
TL;DR: The general extent of organ involvement and the microscopic changes in the lungs remain insufficiently characterised, and autopsies are essential to elucidate COVID‐19‐associated organ alterations.
Journal ArticleDOI
Are we facing a crashing wave of neuropsychiatric sequelae of COVID-19? Neuropsychiatric symptoms and potential immunologic mechanisms.
TL;DR: Prospective neuropsychiatric monitoring of individuals exposed to SARS-CoV-2 at various points in the life course, as well as their neuroimmune status, are needed to fully understand the long-term impact of COVID-19, and to establish a framework for integrating psychoneuroimmunology into epidemiologic studies of pandemics.
Journal ArticleDOI
Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
Richard T. Eastman,Jacob S. Roth,Jacob S. Roth,Kyle R. Brimacombe,Anton Simeonov,Min Shen,Samarjit Patnaik,Matthew D. Hall +7 more
TL;DR: An overview of remdesivir’s discovery, mechanism of action, and the current studies exploring its clinical effectiveness is provided.
References
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TL;DR: An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-n coV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses.
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