Book ChapterDOI
Neurobiological Mechanisms for Impulsive-Aggression: The Role of MAOA
TLDR
Current data on the genetics and neurobiology of individual differences in impulsive-aggression are reviewed, with particular attention to the role of genetic variation in Monoamine Oxidase A and its impact on serotonergic signaling within corticolimbic circuitry.Abstract:
Aggression may be present across a large part of the spectrum of psychopathology, and underlies costly criminal antisocial behaviors. Human aggression is a complex and underspecified construct, confounding scientific discovery. Nevertheless, some biologically tractable subtypes are apparent, and one in particular—impulsive (reactive) aggression—appears to account for many facets of aggression-related dysfunction in psychiatric illness. Impulsive-aggression is significantly heritable, suggesting genetic transmission. However, the specific neurobiological mechanisms that mediate genetic risk for impulsive-aggression remain unclear. Here, we review extant data on the genetics and neurobiology of individual differences in impulsive-aggression, with particular attention to the role of genetic variation in Monoamine Oxidase A (MAOA) and its impact on serotonergic signaling within corticolimbic circuitry.read more
Citations
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Journal ArticleDOI
Antisocial behavior and polymorphisms in the oxytocin receptor gene: findings in two independent samples.
Daniel Hovey,Måns Lindstedt,Anna Zettergren,Lina Jonsson,Ada Johansson,Ada Johansson,Jonas Melke,Nóra Kerekes,Nóra Kerekes,Henrik Anckarsäter,Paul Lichtenstein,Sebastian Lundström,Sebastian Lundström,Lars Westberg +13 more
TL;DR: It is concluded that the rs7632287 and rs4564970 polymorphisms in OXTR may independently influence antisocial behavior in adolescent boys.
Posted Content
Predicting Violent Behavior: What Can Neuroscience Add?
Russell A. Poldrack,John Monahan,Peter B. Imrey,Peter B. Imrey,Valerie F. Reyna,Marcus E. Raichle,David L. Faigman,Joshua W. Buckholtz +7 more
TL;DR: The current status of violence prediction using actuarial and clinical methods is reviewed, and several questions that need to be addressed by future studies of neuroprediction if neuroimaging and other neuroscientific markers are to be successfully translated into public policy are outlined.
Journal ArticleDOI
The role of monoamine oxidase A in the neurobiology of aggressive, antisocial, and violent behavior: A tale of mice and men.
Nathan J. Kolla,Marco Bortolato +1 more
TL;DR: How the convergence of human and animal research is proving helpful to understanding of how MAOA influences antisocial and violent behavior is shown and how it may assist in the development of preventative and therapeutic strategies for aggressive manifestations is shown.
Journal ArticleDOI
The Ventral Hippocampus Controls Stress-Provoked Impulsive Aggression through the Ventromedial Hypothalamus in Post-Weaning Social Isolation Mice
Chih Hua Chang,Po Wu Gean +1 more
TL;DR: It is reported that acute stress activates ventral hippocampus (vHip) neurons to induce attack behavior in post-weaning socially isolated mice, and optogenetic inhibition of vHip neural activity blunts stress-provoked attack behavior, whereas chemogenetic activation promotes it.
Journal ArticleDOI
Nitric oxide interacts with monoamine oxidase to modulate aggression and anxiety-like behaviour
Héctor Carreño Gutiérrez,Aet O'Leary,Florian Freudenberg,Giorgio Fedele,Robert N. Wilkinson,Eleanor Markham,Freek van Eeden,Andreas Reif,William H. J. Norton +8 more
TL;DR: This cross-species approach challenges the previous notion that reduced neuronal NOS leads to increased aggression and finds Nos1 knock-out can also lead to decreased aggression in some situations, a finding that may have implications for future translational research.
References
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Journal ArticleDOI
Role of Genotype in the Cycle of Violence in Maltreated Children
Avshalom Caspi,Avshalom Caspi,Joseph L. McClay,Terrie E. Moffitt,Terrie E. Moffitt,Jonathan Mill,Judy Martin,Ian W. Craig,Alan Taylor,Richie Poulton +9 more
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Journal ArticleDOI
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Journal ArticleDOI
Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A
TL;DR: Analytical results indicate that isolated complete MAOA deficiency in this family is associated with a recognizable behavioral phenotype that includes disturbed regulation of impulsive aggression.
Journal ArticleDOI
Impairment of social and moral behavior related to early damage in human prefrontal cortex.
TL;DR: Early-onset prefrontal damage resulted in a syndrome resembling psychopathy, suggesting that the acquisition of complex social conventions and moral rules had been impaired.
Journal ArticleDOI
Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys.
S. T. Carmichael,Joseph L. Price +1 more
TL;DR: This study has shown that the orbital and medial prefrontal cortex (OMPFC) is extensively connected with medial temporal and cingulate limbic structures, and the organization of these projections was defined in relation to architectonic areas within the OMPFC.