Book ChapterDOI
Neurobiological Mechanisms for Impulsive-Aggression: The Role of MAOA
TLDR
Current data on the genetics and neurobiology of individual differences in impulsive-aggression are reviewed, with particular attention to the role of genetic variation in Monoamine Oxidase A and its impact on serotonergic signaling within corticolimbic circuitry.Abstract:
Aggression may be present across a large part of the spectrum of psychopathology, and underlies costly criminal antisocial behaviors. Human aggression is a complex and underspecified construct, confounding scientific discovery. Nevertheless, some biologically tractable subtypes are apparent, and one in particular—impulsive (reactive) aggression—appears to account for many facets of aggression-related dysfunction in psychiatric illness. Impulsive-aggression is significantly heritable, suggesting genetic transmission. However, the specific neurobiological mechanisms that mediate genetic risk for impulsive-aggression remain unclear. Here, we review extant data on the genetics and neurobiology of individual differences in impulsive-aggression, with particular attention to the role of genetic variation in Monoamine Oxidase A (MAOA) and its impact on serotonergic signaling within corticolimbic circuitry.read more
Citations
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selective Reductions in Prefrontal Glucose Metabolism in Murderers
Adrian Raine,Monte S. Buchsbaum,Jill Stanley,S. Lottenberg,L. Abel,Jacqueline Stoddard,Herbert Y. Meltzer +6 more
TL;DR: The preliminary results suggest that deficits localized to the prefrontal cortex may be related to violence in a selected group of offenders, although further studies are needed to establish the generalizability of these findings to violent offenders in the community.
Genetic background of extreme violent behavior
Jari Tiihonen,M-R Rautiainen,Hanna Ollila,Eila Repo-Tiihonen,Matti Virkkunen,Aarno Palotie,Olli Pietiläinen,Kati Kristiansson,Matti Joukamaa,Hannu Lauerma,Janna Saarela,Sasu Tyni,Heikki Vartiainen,Jussi Paananen,David Goldman,Tiina Paunio +15 more
TL;DR: In this article, the authors found that both low monoamine metabolism and neuronal membrane dysfunction are plausible factors in the etiology of extreme criminal violent behavior, and imply that at least about 5-10% of all severe violent crime in Finland is attributable to the aforementioned MAOA and CDH13 genotypes.
Journal ArticleDOI
Genetic background of extreme violent behavior.
Jari Tiihonen,M-R Rautiainen,Hanna Ollila,Eila Repo-Tiihonen,Matti Virkkunen,Aarno Palotie,Olli Pietiläinen,Kati Kristiansson,Matti Joukamaa,Hannu Lauerma,Janna Saarela,Sasu Tyni,Heikki Vartiainen,Jussi Paananen,David Goldman,Tiina Paunio +15 more
TL;DR: Low monoamine metabolism and neuronal membrane dysfunction are indicated as plausible factors in the etiology of extreme criminal violent behavior, and imply that at least about 5–10% of all severe violent crime in Finland is attributable to the aforementioned MAOA and CDH13 genotypes.
Journal ArticleDOI
The role of monoamine oxidase A in aggression: Current translational developments and future challenges
TL;DR: How an integrated translational strategy coordinating clinical and preclinical research may prove critical to elucidate important aspects of the pathophysiology of aggression, and identify potential targets for its diagnosis, prevention and treatment is emphasized.
Journal ArticleDOI
Drugs related to monoamine oxidase activity.
TL;DR: Desirable effects of MAO inhibition include increased availability of monoamine neurotransmitters, decreased oxidative stress, decreased formation of neurotoxins, induction of pro-survival genes and antiapoptotic factors, and improved mitochondrial functions.
References
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Journal ArticleDOI
Association analysis of the functional monoamine oxidase A gene promoter polymorphism in psychiatric disorders.
Yana V. Syagailo,Gerald Stöber,Marcus Grässle,Ella Reimer,Michael Knapp,Gerd Jungkunz,Olga Okladnova,Jobst Meyer,Klaus-Peter Lesch +8 more
TL;DR: There is no association between MAOA-LPR genotype and susceptibility to recurrent major depression, bipolar disorder, and schizophrenia in the population of patients tested.
Journal ArticleDOI
Localization of Monoamine Oxidase A and B mRNA in the Rat Brain by In Situ Hybridization
TL;DR: In situ hybridization to visualize MAOA and MAOB mRNAs in the rat brain by using specific cDNA and oligonucleotide probes demonstrates that MAOA mRNA synthesis is wide spread in many catecholaminergic and serotonergic cell groups, whereas MAOB RNA synthesis is far more discrete and limited.
Journal ArticleDOI
Social and emotional decision-making following frontal lobe injury.
Luke Clark,Facundo Manes +1 more
TL;DR: Experimental findings using the Iowa Gambling Task and the Cambridge Gamble Task are reviewed that explore the brain mechanisms of decision-making and confirm the importance of ventral PFC, but also highlight the relevance of lesion laterality, lesion aetiology, and the contribution of other brain regions to decision- making abilities.
Journal ArticleDOI
Cerebral Glucose Metabolism, CSF 5-HIAA Levels, and Aggressive Behavior in Rhesus Monkeys
Doudet D,Daniel W. Hommer,James D. Higley,Paul J. Andreason,Moneman R,Stephen J. Suomi,Markku Linnoila +6 more
TL;DR: Aggressive nonhuman primates with low CSF 5-HIAA concentrations may have "innate" tolerance toward functional gamma-aminobutyric acid A receptor agonists such as pentobarbital, isoflurane, and possibly alcohol.
Journal ArticleDOI
Localization of monoamine oxidases in human peripheral tissues.
TL;DR: Localization of monoamine oxidases (MAO) A and B and beta-adrenoceptors, was studied in aged human peripheral tissues by quantitative autoradiography to show marked differences in the abundance and patterns of distribution of MAOs in human and rodent peripheral tissues.