Book ChapterDOI
Neurobiological Mechanisms for Impulsive-Aggression: The Role of MAOA
TLDR
Current data on the genetics and neurobiology of individual differences in impulsive-aggression are reviewed, with particular attention to the role of genetic variation in Monoamine Oxidase A and its impact on serotonergic signaling within corticolimbic circuitry.Abstract:
Aggression may be present across a large part of the spectrum of psychopathology, and underlies costly criminal antisocial behaviors. Human aggression is a complex and underspecified construct, confounding scientific discovery. Nevertheless, some biologically tractable subtypes are apparent, and one in particular—impulsive (reactive) aggression—appears to account for many facets of aggression-related dysfunction in psychiatric illness. Impulsive-aggression is significantly heritable, suggesting genetic transmission. However, the specific neurobiological mechanisms that mediate genetic risk for impulsive-aggression remain unclear. Here, we review extant data on the genetics and neurobiology of individual differences in impulsive-aggression, with particular attention to the role of genetic variation in Monoamine Oxidase A (MAOA) and its impact on serotonergic signaling within corticolimbic circuitry.read more
Citations
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selective Reductions in Prefrontal Glucose Metabolism in Murderers
Adrian Raine,Monte S. Buchsbaum,Jill Stanley,S. Lottenberg,L. Abel,Jacqueline Stoddard,Herbert Y. Meltzer +6 more
TL;DR: The preliminary results suggest that deficits localized to the prefrontal cortex may be related to violence in a selected group of offenders, although further studies are needed to establish the generalizability of these findings to violent offenders in the community.
Genetic background of extreme violent behavior
Jari Tiihonen,M-R Rautiainen,Hanna Ollila,Eila Repo-Tiihonen,Matti Virkkunen,Aarno Palotie,Olli Pietiläinen,Kati Kristiansson,Matti Joukamaa,Hannu Lauerma,Janna Saarela,Sasu Tyni,Heikki Vartiainen,Jussi Paananen,David Goldman,Tiina Paunio +15 more
TL;DR: In this article, the authors found that both low monoamine metabolism and neuronal membrane dysfunction are plausible factors in the etiology of extreme criminal violent behavior, and imply that at least about 5-10% of all severe violent crime in Finland is attributable to the aforementioned MAOA and CDH13 genotypes.
Journal ArticleDOI
Genetic background of extreme violent behavior.
Jari Tiihonen,M-R Rautiainen,Hanna Ollila,Eila Repo-Tiihonen,Matti Virkkunen,Aarno Palotie,Olli Pietiläinen,Kati Kristiansson,Matti Joukamaa,Hannu Lauerma,Janna Saarela,Sasu Tyni,Heikki Vartiainen,Jussi Paananen,David Goldman,Tiina Paunio +15 more
TL;DR: Low monoamine metabolism and neuronal membrane dysfunction are indicated as plausible factors in the etiology of extreme criminal violent behavior, and imply that at least about 5–10% of all severe violent crime in Finland is attributable to the aforementioned MAOA and CDH13 genotypes.
Journal ArticleDOI
The role of monoamine oxidase A in aggression: Current translational developments and future challenges
TL;DR: How an integrated translational strategy coordinating clinical and preclinical research may prove critical to elucidate important aspects of the pathophysiology of aggression, and identify potential targets for its diagnosis, prevention and treatment is emphasized.
Journal ArticleDOI
Drugs related to monoamine oxidase activity.
TL;DR: Desirable effects of MAO inhibition include increased availability of monoamine neurotransmitters, decreased oxidative stress, decreased formation of neurotoxins, induction of pro-survival genes and antiapoptotic factors, and improved mitochondrial functions.
References
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The serotonin transporter genotype is associated with intermediate brain phenotypes that depend on the context of eliciting stressor.
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Journal ArticleDOI
The vicious cycle towards violence: focus on the negative feedback mechanisms of brain serotonin neurotransmission.
TL;DR: A revised view is presented on the key role of central serotonergic (auto)regulatory mechanisms in this transition of normal aggression into violence.
Journal ArticleDOI
Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity.
Christian Jacob,Johannes Müller,Michael Schmidt,Katrin Hohenberger,Lise Gutknecht,Andreas Reif,Armin Schmidtke,Rainald Mössner,Klaus-Peter Lesch +8 more
TL;DR: The notion that allelic variation of MAOA activity contributes modestly to the balance of hyper- (impulsive-aggressive) and hyporeactive (anxious-depressive) traits is supported.
Journal ArticleDOI
A Polymorphism of the MAOA Gene is Associated with Emotional Brain Markers and Personality Traits on an Antisocial Index
Leanne M. Williams,Justine M. Gatt,Stacey A. Kuan,Carol Dobson-Stone,Carol Dobson-Stone,Donna M. Palmer,Robert H. Paul,Le Song,Paul T. Costa,Peter R. Schofield,Peter R. Schofield,Evian Gordon,Evian Gordon +12 more
TL;DR: The MAOA low activity variant may increase susceptibility to antisocial traits through alterations to the neural systems for processing threat-related emotion, especially for males.