Book ChapterDOI
Neurobiological Mechanisms for Impulsive-Aggression: The Role of MAOA
TLDR
Current data on the genetics and neurobiology of individual differences in impulsive-aggression are reviewed, with particular attention to the role of genetic variation in Monoamine Oxidase A and its impact on serotonergic signaling within corticolimbic circuitry.Abstract:
Aggression may be present across a large part of the spectrum of psychopathology, and underlies costly criminal antisocial behaviors. Human aggression is a complex and underspecified construct, confounding scientific discovery. Nevertheless, some biologically tractable subtypes are apparent, and one in particular—impulsive (reactive) aggression—appears to account for many facets of aggression-related dysfunction in psychiatric illness. Impulsive-aggression is significantly heritable, suggesting genetic transmission. However, the specific neurobiological mechanisms that mediate genetic risk for impulsive-aggression remain unclear. Here, we review extant data on the genetics and neurobiology of individual differences in impulsive-aggression, with particular attention to the role of genetic variation in Monoamine Oxidase A (MAOA) and its impact on serotonergic signaling within corticolimbic circuitry.read more
Citations
More filters
selective Reductions in Prefrontal Glucose Metabolism in Murderers
Adrian Raine,Monte S. Buchsbaum,Jill Stanley,S. Lottenberg,L. Abel,Jacqueline Stoddard,Herbert Y. Meltzer +6 more
TL;DR: The preliminary results suggest that deficits localized to the prefrontal cortex may be related to violence in a selected group of offenders, although further studies are needed to establish the generalizability of these findings to violent offenders in the community.
Genetic background of extreme violent behavior
Jari Tiihonen,M-R Rautiainen,Hanna Ollila,Eila Repo-Tiihonen,Matti Virkkunen,Aarno Palotie,Olli Pietiläinen,Kati Kristiansson,Matti Joukamaa,Hannu Lauerma,Janna Saarela,Sasu Tyni,Heikki Vartiainen,Jussi Paananen,David Goldman,Tiina Paunio +15 more
TL;DR: In this article, the authors found that both low monoamine metabolism and neuronal membrane dysfunction are plausible factors in the etiology of extreme criminal violent behavior, and imply that at least about 5-10% of all severe violent crime in Finland is attributable to the aforementioned MAOA and CDH13 genotypes.
Journal ArticleDOI
Genetic background of extreme violent behavior.
Jari Tiihonen,M-R Rautiainen,Hanna Ollila,Eila Repo-Tiihonen,Matti Virkkunen,Aarno Palotie,Olli Pietiläinen,Kati Kristiansson,Matti Joukamaa,Hannu Lauerma,Janna Saarela,Sasu Tyni,Heikki Vartiainen,Jussi Paananen,David Goldman,Tiina Paunio +15 more
TL;DR: Low monoamine metabolism and neuronal membrane dysfunction are indicated as plausible factors in the etiology of extreme criminal violent behavior, and imply that at least about 5–10% of all severe violent crime in Finland is attributable to the aforementioned MAOA and CDH13 genotypes.
Journal ArticleDOI
The role of monoamine oxidase A in aggression: Current translational developments and future challenges
TL;DR: How an integrated translational strategy coordinating clinical and preclinical research may prove critical to elucidate important aspects of the pathophysiology of aggression, and identify potential targets for its diagnosis, prevention and treatment is emphasized.
Journal ArticleDOI
Drugs related to monoamine oxidase activity.
TL;DR: Desirable effects of MAO inhibition include increased availability of monoamine neurotransmitters, decreased oxidative stress, decreased formation of neurotoxins, induction of pro-survival genes and antiapoptotic factors, and improved mitochondrial functions.
References
More filters
Journal ArticleDOI
Connectional networks within the orbital and medial prefrontal cortex of macaque monkeys
S. T. Carmichael,Joseph L. Price +1 more
TL;DR: The intrinsic cortico‐cortical connections within the orbital and medial prefrontal cortex (OMPFC) were demonstrated with retrograde and anterograde tracers injected into each of the architectonic areas that constitute this region.
Journal ArticleDOI
A common allele in the oxytocin receptor gene (OXTR) impacts prosocial temperament and human hypothalamic-limbic structure and function
Heike Tost,Bhaskar Kolachana,Shabnam Hakimi,Herve Lemaitre,Beth A. Verchinski,Venkata S. Mattay,Daniel R. Weinberger,Andreas Meyer-Lindenberg +7 more
TL;DR: Evidence for structural alterations in key oxytocinergic regions emerged, particularly in the hypothalamus, and these neural characteristics predicted lower levels of reward dependence in male risk allele carriers.
Journal ArticleDOI
Amygdala and orbitofrontal reactivity to social threat in individuals with impulsive aggression.
TL;DR: Findings provide evidence of amygdala-OFC dysfunction in response to an ecologically-valid social threat signal (processing angry faces) in individuals with a history of impulsive aggressive behavior, and further substantiate a link between a dysfunctional cortico-limbic network and aggression.
Journal ArticleDOI
Childhood adversity, monoamine oxidase a genotype, and risk for conduct disorder.
Debra L. Foley,Lindon J. Eaves,Brandon Wormley,Judy L. Silberg,Hermine H. Maes,Jonathan W. Kuhn,Brien P. Riley +6 more
TL;DR: This study replicates a recent report of a genotype-environment interaction that predicts individual variation in risk for antisocial behavior in boys and finds that low monoamine oxidase A activity increased risk for conduct disorder only in the presence of an adverse childhood environment.
Journal ArticleDOI
Lack of Barrels in the Somatosensory Cortex of Monoamine Oxidase A-Deficient Mice: Role of a Serotonin Excess during the Critical Period
Olivier Cases,Tania Vitalis,Isabelle Seif,Edward De Maeyer,Constantino Sotelo,Patricia Gaspar +5 more
TL;DR: It is shown that the primary somatosensory cortex (S1) lacks the characteristic barrel-like clustering of layer IV neurons, whereas normal pattern formation exists in the thalamus and the trigeminal nuclei.