Journal ArticleDOI
New old challenges in tuberculosis: potentially effective nanotechnologies in drug delivery.
Alejandro Sosnik,Angel M. Carcaboso,Romina Julieta Glisoni,Marcela A. Moretton,Diego A. Chiappetta +4 more
TLDR
The present review thoroughly overviews the state-of-the-art in the development of nano-based drug delivery systems for encapsulation and release of anti-TB drugs and discusses the challenges that are faced in theDevelopment of a more effective, compliant and also affordable TB pharmacotherapy.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2010-03-18. It has received 252 citations till now. The article focuses on the topics: Population.read more
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"Nanoantibiotics": a new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era.
Ae Jung Huh,Young Jik Kwon +1 more
TL;DR: This review summarizes emerging efforts in combating against infectious diseases, particularly using antimicrobial NPs and antibiotics delivery systems as new tools to tackle the current challenges in treating infectious diseases.
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Toxicology and clinical potential of nanoparticles.
Lara Yildirimer,Nguyen T. K. Thanh,Nguyen T. K. Thanh,Marilena Loizidou,Alexander M. Seifalian,Alexander M. Seifalian +5 more
TL;DR: This work states that current research lacks a unifying protocol for the toxicological profiling of NPs and in vitro toxicity results do not easily translate into in vivo toxicity.
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Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives
TL;DR: This critical review focuses on the design of biocompatible dendrimer-based nanoplatforms for targeted cancer diagnosis and therapy and theBiocompatibility aspects of d endrimers such as nanotoxicity, long-term circulation, and degradation are discussed.
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Nanoparticles: Alternatives Against Drug-Resistant Pathogenic Microbes.
TL;DR: The present review highlights the antimicrobial effects of various nanomaterials and their potential advantages, drawbacks, or side effects and may be useful in the discovery of broad-spectrum antimicrobial drugs for use against multi-drug-resistant microbial pathogens in the near future.
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Delivery of antibiotics with polymeric particles.
TL;DR: The delivery of antibiotics with polymeric particles augments the level of the bioactive drug at the site of infection while reducing the dosage and the dosing frequency, resulting in improved therapeutic effects as well as decreased "pill burden" and drug side effects in patients.
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
TL;DR: Experimental and computational approaches to estimate solubility and permeability in discovery and development settings are described in this article, where the rule of 5 is used to predict poor absorption or permeability when there are more than 5 H-bond donors, 10 Hbond acceptors, and the calculated Log P (CLogP) is greater than 5 (or MlogP > 415).
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Block copolymer micelles for drug delivery: design, characterization and biological significance
TL;DR: The utility of polymeric micelles formed through the multimolecular assembly of block copolymers as novel core-shell typed colloidal carriers for drug and gene targeting and their feasibility as non-viral gene vectors is highlighted.
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Biodegradable polymeric nanoparticles as drug delivery devices
TL;DR: This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.
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Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
TL;DR: This work has shown that addition of PEG and PEG-containing copolymers to the surface of nanoparticles results in an increase in the blood circulation half-life of the particles by several orders of magnitude, and creates a hydrophilic protective layer around the nanoparticles that is able to repel the absorption of opsonin proteins via steric repulsion forces.
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Cyclodextrins as pharmaceutical solubilizers.
TL;DR: This review is intended to give a general background to the use of cyclodextrin as solubilizers as well as highlight kinetic and thermodynamic tools and parameters useful in the study of drug Solubilization bycyclodextrins.