Journal ArticleDOI
Niacin and its metabolites as master regulators of macrophage activation.
Sergio Montserrat-de la Paz,M. Carmen Naranjo,Sergio López,Rocio Abia,Francisco J. G. Muriana,Beatriz Bermudez +5 more
TLDR
This study reveals for the first time that niacin and its metabolites possess antioxidant, reprogramming and antiinflammatory properties on human primary monocytes and monocyte-derived macrophages.Abstract:
Niacin is a broad-spectrum lipid-regulating drug used for clinical therapy of chronic high-grade inflammatory diseases. However, the mechanisms by which either niacin or the byproducts of its catabolism ameliorate these inflammatory diseases are not clear yet. Human circulating monocytes and mature macrophages were used to analyze the effects of niacin and its metabolites (NAM, NUA and 2-Pyr) on oxidative stress, plasticity and inflammatory response by using biochemical, flow cytometry, quantitative real-time PCR and Western blot technologies. Niacin, NAM and 2-Pyr significantly decreased ROS, NO and NOS2 expression in LPS-treated human mature macrophages. Niacin and NAM skewed macrophage polarization toward antiinflammatory M2 macrophage whereas a trend toward proinflammatory M1 macrophage was noted following treatment with NUA. Niacin and NAM also reduced the inflammatory competence of LPS-treated human mature macrophages and promoted bias toward antiinflammatory CD14+CD16++ nonclassical human primary monocytes. This study reveals for the first time that niacin and its metabolites possess antioxidant, reprogramming and antiinflammatory properties on human primary monocytes and monocyte-derived macrophages. Our findings imply a new understanding of the mechanisms by which niacin and its metabolites favor a continuous and gradual plasticity process in the human monocyte/macrophage system.read more
Citations
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Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota-Immune System Interplay. Implications for Health and Disease.
Cielo García-Montero,Oscar Fraile-Martínez,Ana M Gómez-Lahoz,Leonel Pekarek,Alejandro J. Castellanos,Fernando Noguerales-Fraguas,Santiago Coca,Santiago Coca,Luis G. Guijarro,Natalio García-Honduvilla,Natalio García-Honduvilla,Ángel Asúnsolo,Ángel Asúnsolo,Lara Sanchez-Trujillo,Lara Sanchez-Trujillo,Guillermo Lahera,Guillermo Lahera,Julia Buján,Julia Buján,Jorge Monserrat,Jorge Monserrat,Melchor Alvarez-Mon,Miguel Angel Alvarez-Mon,Miguel A Ortega +23 more
TL;DR: In this article, the regulatory role of nutritional components of WD and MD in the gut microbiota and immune system interplay, in order to understand, and create awareness of, the influence of diet over both key components.
Journal ArticleDOI
Nicotinamide metabolism regulates glioblastoma stem cell maintenance
Jinkyu Jung,Leo J.Y. Kim,Xiuxing Wang,Qiulian Wu,Tanwarat Sanvoranart,Christopher G. Hubert,Briana C. Prager,Lisa C. Wallace,Xun Jin,Stephen C. Mack,Jeremy N. Rich,Jeremy N. Rich +11 more
TL;DR: Findings support NNMT as a GSC-specific therapeutic target in glioblastoma by disrupting oncogenic DNA hypomethylation and supporting a mechanistic link between NN MT and DNA methylation.
Journal ArticleDOI
Meat and Nicotinamide: A Causal Role in Human Evolution, History, and Demographics.
Adrian C Williams,Lisa J Hill +1 more
TL;DR: This work views human evolution, recent history, and agricultural and demographic transitions in the light of meat and nicotinamide intake, and highlights a biochemical and immunological switch that affects fertility in the ‘de novo’ tryptophan-to-kynurenine-nicotinamide ‘immune tolerance’ pathway.
Journal ArticleDOI
Neuroprotective protein hydrolysates from hemp (Cannabis sativa L.) seeds.
Noelia M. Rodríguez-Martín,Noelia M. Rodríguez-Martín,Rocío Toscano,Rocío Toscano,Álvaro Villanueva,Justo Pedroche,Francisco Millán,Sergio Montserrat-de la Paz,María del Carmen Millán-Linares +8 more
TL;DR: This study suggests for the first time that HPHs may improve the neuroinflammatory and inflammatory states, supporting the nutraceutical value of hemp seeds.
Journal ArticleDOI
Meat Intake and the Dose of Vitamin B3 - Nicotinamide: Cause of the Causes of Disease Transitions, Health Divides, and Health Futures?
Lisa J Hill,Adrian C Williams +1 more
TL;DR: An optimal dosage of vitamin B3 could lead to better health, but such a preventive approach needs more equitable meat distribution and some people may require personalised doses depending on genetic make-up or, temporarily, when under stress.
References
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Peter J. Murray,Thomas A. Wynn +1 more
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Alternative Activation of Macrophages: Mechanism and Functions
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Loems Ziegler-Heitbrock,Petronela Ancuta,Suzanne M. Crowe,Marc Dalod,Marc Dalod,Veronika Grau,Derek N.J. Hart,Pieter J. M. Leenen,Yong-Jun Liu,G. Gordon MacPherson,Gwendalyn J. Randolph,Juergen E. Scherberich,Juergen Schmitz,Ken Shortman,Silvano Sozzani,Herbert Strobl,Marek Zembala,Jonathan M. Austyn,Manfred B. Lutz +18 more
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Journal ArticleDOI
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
Paola Italiani,Diana Boraschi +1 more
TL;DR: This review will address some of the important questions under the general framework of the role of monocytes and macrophages in the initiation, development, resolution, and chronicization of inflammation.
Journal ArticleDOI
Macrophage Polarization in Bacterial Infections
TL;DR: The relevance of macrophage polarization in three domains of infectious diseases: resistance to infection, infectious pathogenesis, and chronic evolution of infectious disease is discussed.