Journal ArticleDOI
Nitric oxide in immunity and inflammation
TLDR
Several key enzymes in mitochondrial respiration are inhibited by RNOS and this leads to a depletion of ATP and cellular energy, which may explain the multiple actions of NO in the regulation of immune and inflammatory cells.About:
This article is published in International Immunopharmacology.The article was published on 2001-08-01. It has received 774 citations till now. The article focuses on the topics: Immune system & Nitric oxide synthase.read more
Citations
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Journal Article
Nitric oxide and superoxide in inflammation and immune regulation.
TL;DR: The mechanisms of nitric oxide and superoxide dependent modulation of inflammatory reactions in experimental animals and humans are discussed and the potential role of these polymorphisms in inflammation and susceptibility to infection is discussed.
Journal ArticleDOI
Phagocytosis checkpoints as new targets for cancer immunotherapy.
TL;DR: An improved understanding of the tumour-intrinsic processes that inhibit essential immune surveillance processes, such as phagocytosis and innate immune sensing, could pave the way for the development of highly effective combination immunotherapy strategies that modulate both innate and adaptive antitumour immune responses.
Journal ArticleDOI
Nitric oxide, a double edged sword in cancer biology: Searching for therapeutic opportunities
TL;DR: It is suggested that NO should be considered neither a universal target nor a magic bullet, but rather a signal transducer to be modulated according to the molecular makeup of each individual cancer and the interplay with conventional antineoplastic agents.
Journal ArticleDOI
Inflammation and Lung Cancer: Roles of Reactive Oxygen/Nitrogen Species
TL;DR: It is conceivable that chronic inflammation-induced production of ROS/RNS in the lung may predispose individuals to lung cancer, and the role of ROS/, or reactive oxygen/nitrogen species, in cancer development is highlighted.
Book ChapterDOI
Scaffolds for tissue engineering and 3D cell culture.
TL;DR: This chapter reviews the principal polymeric materials that are used for the fabrication of scaffolds and the scaffold fabrication processes, with examples of properties and selected applications.
References
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Journal Article
Nitric oxide: physiology, pathophysiology, and pharmacology
Journal ArticleDOI
Nitric oxide synthases: Roles, tolls, and controls
Carl Nathan,Qiao-wen Xie +1 more
TL;DR: The next ten years will bring forth evidence that NO is produced in slime molds, locusts, beetles, horseshoe crabs, mollusks, chickens, mice, rats, cows, and humans, and its physiologic roles will be at least as protean as those discovered for corticosteroids in the 194Os- 1980s.
Journal ArticleDOI
Redox signaling: nitrosylation and related target interactions of nitric oxide.
Journal ArticleDOI
Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite.
TL;DR: An L-arginine-dependent biochemical pathway synthesizing L-citrulline and nitrite, coupled to an effector mechanism, is shown to cause this pattern of metabolic inhibition in cytotoxic activated macrophages.
Journal ArticleDOI
Increased nitric oxide in exhaled air of asthmatic patients
Sergei A. Kharitonov,Deborah H Yates,Richard A. Robbins,Peter J. Barnes,R B Logan-Sinclair,E.A. Shinebourne +5 more
TL;DR: In this paper, the authors measured the NO in patients with asthma using a slow vital capacity manoeuvre and an adapted chemiluminescence analyser and found that NO was detectable in exhaled air of 67 control subjects (mean peak concentration 80·2 [SE4·1] ppb) and was significantly reduced by inhaling the specific NO synthase inhibitor N G -monomethyl-Larginine.