Non-human primates and Leishmania immunity.
Sonia André,Vasco Rodrigues,Morgane Picard,Ricardo Silvestre,Jérôme Estaquier,Jérôme Estaquier +5 more
- Vol. 2, Iss: 4, pp 100038
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TLDR
The contribution of NHP models for understanding the immunity to leishmaniases, which are a group of diseases caused by infection with protozoan parasites of the genus Leishmania, is summarized.Abstract:
In the context of infectious diseases, non-human primates (NHP) provide the best animal models of human diseases due to the close phylogenetic relationship and the similar physiology and anatomical systems. Herein, we summarized the contribution of NHP models for understanding the immunity to leishmaniases, which are a group of diseases caused by infection with protozoan parasites of the genus Leishmania and classified as one of the neglected tropical diseases.read more
Citations
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Role of Cytokines in Experimental and Human Visceral Leishmaniasis.
TL;DR: In this paper, the role of cytokines involved in leishmaniasis disease progression or host protection in different animal models and humans was discussed, which will determine the clinical outcome of VL and open the path for the development of rapid and accurate diagnostic tools as well as therapeutic interventions against VL.
Journal ArticleDOI
Cytokines in the immunity and immunopathogenesis in leishmaniases.
Bhaskar Saha,Ricardo Silvestre +1 more
TL;DR: The operational frameworks for different cytokines have been laid to discuss how these immune mediators control each of these forms of leishmaniases and one of these frameworks is the regulation of monocytopoiesis including the role of macrophages subsets and thrombopoiedis in leish maniases.
Studies on the immunology and serology of leishmaniasis: III. On the cross-immunity between panamanian cutaneous leishmaniasis and Leishmania mexicana infection in man (Publicado originalmente em 1966)
Ralph Lainson,Jeffrey Jon Shaw +1 more
Journal ArticleDOI
Epigenetic paradigms/exemplars of the macrophage: inflammasome axis in Leishmaniasis
TL;DR: The review configures research findings aligning to the epigenetic epidemiology niche, involving co-evolutionary epigenetic inheritance and plasticity disease models that focus on the host-pathogen interactome expanse at the macrophage-inflammasome axis.
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