Journal ArticleDOI
Normothermic regional perfusion vs. super-rapid recovery in controlled donation after circulatory death liver transplantation.
Amelia J. Hessheimer,Elisabeth Coll,Ferran Torres,Patricia Ruiz,Mikel Gastaca,José Ignacio Rivas,Manuel Gómez,B. Sanchez,Julio Santoyo,Pablo Ramírez,Pascual Parrilla,Luis Miguel Marín,Miguel Ángel Gómez-Bravo,Juan Carlos García-Valdecasas,Javier López-Monclús,Andrea Boscá,Rafael López-Andújar,Jiliam Fundora-Suárez,Jesús Villar,Álvaro García-Sesma,Carlos Jiménez,G. Rodriguez-Laiz,Laura Lladó,Juan Carlos Rodríguez,Manuel Barrera,Ramón Charco,Jose Ángel López-Baena,Javier Briceño,Fernando Pardo,Gerardo Blanco,David Pacheco,Beatriz Domínguez-Gil,Víctor Sánchez Turrión,Constantino Fondevila +33 more
TLDR
The study results suggest that the use of postmortem normothermic regional perfusion helps reduce rates of post-transplant biliary complications and graft loss and allows for the successful transplantation of livers from older cDCD donors of advanced age.About:
This article is published in Journal of Hepatology.The article was published on 2019-04-01. It has received 173 citations till now. The article focuses on the topics: Transplantation & Liver transplantation.read more
Citations
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Journal ArticleDOI
Transplantation of discarded livers following viability testing with normothermic machine perfusion
Hynek Mergental,Hynek Mergental,Richard W. Laing,Richard W. Laing,Amanda Kirkham,M. Thamara P. R. Perera,Yuri L. Boteon,Yuri L. Boteon,Joseph Attard,Joseph Attard,Darren Barton,Stuart M. Curbishley,Stuart M. Curbishley,Manpreet Wilkhu,Desley Neil,Desley Neil,Stefan G. Hübscher,Stefan G. Hübscher,Paolo Muiesan,John Isaac,Keith J. Roberts,Keith J. Roberts,Manuel Abradelo,A. Schlegel,A. Schlegel,James Ferguson,Hentie Cilliers,Julian Bion,David H. Adams,David H. Adams,Christopher Morris,P Friend,Christina Yap,Christina Yap,Simon C. Afford,Simon C. Afford,Darius F. Mirza,Darius F. Mirza +37 more
TL;DR: The VITTAL clinical trial as discussed by the authors used normothermic machine perfusion (NMP) to objectively assess livers discarded by all UK centres meeting specific high-risk criteria, which enabled successful transplantation of 71% of discarded livers, with 100% 90-day patient and graft survival; it does not seem to prevent nonanastomotic biliary strictures in livers donated after circulatory death with prolonged warm ischaemia.
Journal ArticleDOI
Transplantation of High-risk Donor Livers After Ex Situ Resuscitation and Assessment Using Combined Hypo- and Normothermic Machine Perfusion: A Prospective Clinical Trial.
Otto B. van Leeuwen,Yvonne de Vries,Masato Fujiyoshi,Maarten W. N. Nijsten,Rinse Ubbink,Gert Jan Pelgrim,Maureen J M Werner,Koen Reyntjens,Aad P. van den Berg,Marieke T. de Boer,Ruben H J de Kleine,Ton Lisman,Vincent E de Meijer,Robert J. Porte +13 more
TL;DR: Sequential DHOPE-COR-NMP enabled resuscitation and safe selection of initially declined high-risk donor livers, thereby increasing the number of transplantable livers by 20%.
Journal ArticleDOI
Donation after circulatory death today: an updated overview of the European landscape.
Mar Lomero,Dale Gardiner,Elisabeth Coll,Bernadette J. J. M. Haase-Kromwijk,Francesco Procaccio,Franz Immer,Lyalya Gabbasova,Corine Antoine,Janis Jushinskis,Nessa Lynch,Stein Foss,Catarina Bolotinha,Tamar Ashkenazi,Luc Colenbie,Andreas Zuckermann,Milos Adamec,Jarosław Czerwiński,Sonata Karčiauskaitė,Helena Ström,Marta López-Fraga,Beatriz Domínguez-Gil +20 more
TL;DR: In conclusion, DCD is becoming increasingly accepted and performed in Europe, importantly contributing to the number of organs available and providing acceptable post‐transplantation outcomes.
Journal ArticleDOI
The future of organ perfusion and re-conditioning.
TL;DR: The findings from clinical studies reported to date suggest that machine perfusion will offer real benefits when compared with conventional cold preservation and several randomized trials are expected to report their findings within the next 2 years which may shed light on the relative merits of different perfusion methods.
Journal ArticleDOI
Transplanting Marginal Organs in the Era of Modern Machine Perfusion and Advanced Organ Monitoring.
Thomas Resch,Benno Cardini,Rupert Oberhuber,Annemarie Weissenbacher,Julia Dumfarth,Christoph Krapf,C. Boesmueller,Dietmar Oefner,Michael Grimm,Sefan Schneeberger +9 more
TL;DR: The current state of MP and advanced organ monitoring is addressed and speculation about logical future steps and how this evolution of a novel technology can result in a medial revolution is speculated.
References
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Journal ArticleDOI
Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors
Kim M. Olthoff,Laura Kulik,Benjamin Samstein,Mary Kaminski,Michael Abecassis,Jean C. Emond,Abraham Shaked,Jason D. Christie +7 more
TL;DR: A simple definition of EAD using objective posttransplant criteria identified a 23% incidence, and was highly associated with graft loss and patient mortality, validating previously published criteria.
Journal ArticleDOI
A randomized trial of normothermic preservation in liver transplantation
D Nasralla,Constantin C. Coussios,Hynek Mergental,M. Zeeshan Akhtar,Andrew J. Butler,Carlo D L Ceresa,Virginia Chiocchia,Susan J Dutton,Juan Carlos García-Valdecasas,Nigel Heaton,Charles Imber,Wayel Jassem,Ina Jochmans,John Karani,Simon R. Knight,Simon R. Knight,Peri Kocabayoglu,Massimo Malagó,Darius F. Mirza,Peter J. Morris,Peter J. Morris,Arvind Pallan,Andreas Paul,Mihai Pavel,M. Thamara P. R. Perera,Jacques Pirenne,R. Ravikumar,Leslie James Russell,Sara Upponi,Christopher J.E. Watson,Annemarie Weissenbacher,Rutger J. Ploeg,Peter J. Friend +32 more
TL;DR: Normothermic machine perfusion of the liver improved early graft function, demonstrated by reduced peak serum aspartate transaminase levels and early allograft dysfunction rates, and improved organ utilization and preservation times, although no differences were seen in graft or patient survival.
Journal ArticleDOI
Liver Transplantation After Ex Vivo Normothermic Machine Preservation: A Phase 1 (First-in-Man) Clinical Trial
R. Ravikumar,Wayel Jassem,Hynek Mergental,Nigel Heaton,Darius F. Mirza,M. T. P. R. Perera,Alberto Quaglia,David Holroyd,Thomas Vogel,Constantin C. Coussios,Peter J. Friend +10 more
TL;DR: This first report of liver transplantation using NMP‐preserved livers demonstrates the safety and feasibility of using this technology from retrieval to transplantation, including transportation, and may be valuable in increasing the number of donor livers and improving the function of transplantable organs.
Journal ArticleDOI
Biliary complications after liver transplantation from donation after cardiac death donors: an analysis of risk factors and long-term outcomes from a single center.
David P. Foley,Luis A. Fernandez,Glen Leverson,Michael E. Anderson,Joshua D. Mezrich,Hans W. Sollinger,Anthony M. D'Alessandro +6 more
TL;DR: The objective of this analysis was to compare the long-term outcomes of DCD and DBD liver transplants with 15 year follow-up, and to identify potential risk factors for the development of biliary complications in DCD liver transplant recipients at the University of Wisconsin.
Journal ArticleDOI
First Comparison of Hypothermic Oxygenated PErfusion Versus Static Cold Storage of Human Donation After Cardiac Death Liver Transplants: An International-matched Case Analysis.
Philipp Dutkowski,Wojciech G. Polak,Paolo Muiesan,Andrea Schlegel,Cornelia J. Verhoeven,Irene Scalera,Michelle L. DeOliveira,Philipp Kron,Pierre-Alain Clavien +8 more
TL;DR: No graft failure due to intrahepatic cholangiopathy or nonfunction occurred in HOPE-treated livers, whereas 18% of unperfused DCD livers needed retransplantation.
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A randomized trial of normothermic preservation in liver transplantation
D Nasralla,Constantin C. Coussios,Hynek Mergental,M. Zeeshan Akhtar,Andrew J. Butler,Carlo D L Ceresa,Virginia Chiocchia,Susan J Dutton,Juan Carlos García-Valdecasas,Nigel Heaton,Charles Imber,Wayel Jassem,Ina Jochmans,John Karani,Simon R. Knight,Simon R. Knight,Peri Kocabayoglu,Massimo Malagó,Darius F. Mirza,Peter J. Morris,Peter J. Morris,Arvind Pallan,Andreas Paul,Mihai Pavel,M. Thamara P. R. Perera,Jacques Pirenne,R. Ravikumar,Leslie James Russell,Sara Upponi,Christopher J.E. Watson,Annemarie Weissenbacher,Rutger J. Ploeg,Peter J. Friend +32 more