Notch1 expression in early lymphopoiesis influences B versus T lineage determination.
John C. Pui,David Allman,Lanwei Xu,Susan DeRocco,Fredrick G. Karnell,Sonia Bakkour,Julia Y Lee,Tom Kadesch,Richard R. Hardy,Jon C. Aster,Warren S. Pear +10 more
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TLDR
The results suggest that Notch1 provides a key regulatory signal in determining T lymphoid versus B lymphoid lineage decisions, possibly by influencing lineage commitment from a common lymphoid progenitor cell.About:
This article is published in Immunity.The article was published on 1999-09-01 and is currently open access. It has received 1021 citations till now. The article focuses on the topics: Lymphopoiesis & Monocyte differentiation.read more
Citations
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Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow
Yoshio Katayama,Yoshio Katayama,Michela Battista,Wei Ming Kao,Andrés Hidalgo,Anna Julie Peired,Steven A. Thomas,Paul S. Frenette +7 more
TL;DR: It is demonstrated that enforced HSPC egress from BM niches depends critically on the nervous system, and results indicate that the sympathetic nervous system regulates the attraction of stem cells to their niche.
Journal ArticleDOI
HES and HERP families: multiple effectors of the Notch signaling pathway.
TL;DR: The identification of the HERP family as a Notch effector that cooperates with HES/E(spl) family has opened a new avenue to the authors' understanding of the Notch signaling pathway.
Journal ArticleDOI
Induction of T Cell Development from Hematopoietic Progenitor Cells by Delta-like-1 In Vitro
TL;DR: It is established that expression of Delta-like-1 on stromal cells provides key signals for the induction of T cell lineage commitment, stage-specific progenitor expansion, TCR gene rearrangement, and T cell differentiation in the absence of a thymus.
Journal ArticleDOI
Metabolic regulation of T lymphocytes.
TL;DR: The role of cellular metabolism in T cell development, activation, differentiation, and function is discussed to highlight the clinical relevance and opportunities for therapeutic interventions that may be used to disrupt immune pathogenesis.
Journal ArticleDOI
Notch signaling is required for arterial-venous differentiation during embryonic vascular development.
Nathan D. Lawson,Nico Scheer,Van N. Pham,Cheol-Hee Kim,Ajay B. Chitnis,José A. Campos-Ortega,Brant M. Weinstein +6 more
TL;DR: The results suggest that notch signaling is required for the proper development of arterial and venous blood vessels, and that a major role of Notch signaling in blood vessels is to repress venous differentiation within developing arteries.
References
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PatentDOI
Production of high titer helper-free retroviruses by transient transfection
TL;DR: In this article, a method for producing high-titer, helper-free infectious retroviruses is disclosed which employs a novel strategy that uses transient transfection of new retroviral producer cell lines, ecotropic line BOSC 23 and amphotropic line CAK 8.
Journal ArticleDOI
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.
Leif W. Ellisen,Jeffrey Bird,Daniel C. West,A. Lee Soreng,Thomas C. Reynolds,Stephen D. Smith,Jeffrey Sklar +6 more
TL;DR: It is shown that the locus on chromosome 9 contains a gene highly homologous to the Drosophila gene Notch, which may be important for normal lymphocyte function and that alteration of TAN-1 may play a role in the pathogenesis of some T cell neoplasms.
Journal ArticleDOI
Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.
TL;DR: Functional analysis demonstrates that the proliferative response to IL-7, an early B lineage growth factor, is restricted to S7+ stages and, furthermore, that an additional, cell contact-mediated signal is essential for survival of Fr.
Journal ArticleDOI
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain.
TL;DR: It is shown that signalling by a constitutively active membrane-bound Notch-1 protein requires the proteolytic release of the Notch intracellular domain (NICD), which interacts preferentially with CSL.
Journal ArticleDOI
Deficient T cell fate specification in mice with an induced inactivation of Notch1.
Freddy Radtke,Anne Wilson,G. Stark,Michelle Bauer,Joost P. M. van Meerwijk,H. Robson MacDonald,Michel Aguet +6 more
TL;DR: It is suggested that Notch1 plays an obligatory and selective role in T cell lineage induction in mice with a neonatally induced loss of Notch 1 function.
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Notch Signaling: Cell Fate Control and Signal Integration in Development
Induction of T Cell Development from Hematopoietic Progenitor Cells by Delta-like-1 In Vitro
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Andrew P. Weng,Andrew P. Weng,Adolfo A. Ferrando,Adolfo A. Ferrando,Woojoong Lee,Woojoong Lee,John P. Morris,John P. Morris,Lewis B. Silverman,Lewis B. Silverman,Cheryll Sanchez-Irizarry,Cheryll Sanchez-Irizarry,Stephen C. Blacklow,Stephen C. Blacklow,A. Thomas Look,A. Thomas Look,Jon C. Aster,Jon C. Aster +17 more