Journal ArticleDOI
Opioid receptors: drivers to addiction?
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TLDR
This Review discusses rapidly advancing research into the role of opioid receptors in addiction, and addresses the key questions of whether the authors can kill pain without addiction using mu-opioid-receptor-targeting opiates and whether to bridge human and animal opioid research in the field of drug abuse.Abstract:
Drug addiction is a worldwide societal problem and public health burden, and results from recreational drug use that develops into a complex brain disorder. The opioid system, one of the first discovered neuropeptide systems in the history of neuroscience, is central to addiction. Recently, opioid receptors have been propelled back on stage by the rising opioid epidemics, revolutions in G protein-coupled receptor research and fascinating developments in basic neuroscience. This Review discusses rapidly advancing research into the role of opioid receptors in addiction, and addresses the key questions of whether we can kill pain without addiction using mu-opioid-receptor-targeting opiates, how mu- and kappa-opioid receptors operate within the neurocircuitry of addiction and whether we can bridge human and animal opioid research in the field of drug abuse.read more
Citations
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BookDOI
Medications for Opioid Use Disorder Save Lives
Michelle Mancher,Alan I. Leshner +1 more
TL;DR: In this article, the evidence base on medication assisted treatment (MAT) for opioid use disorder (OUD) is examined and the available evidence on the range of parameters and circumstances in which MAT can be effectively delivered and identifies additional research needed.
Journal ArticleDOI
Untangling the complexity of opioid receptor function.
Rita J. Valentino,Nora D. Volkow +1 more
TL;DR: Basic research into the chemistry and pharmacology of opioid receptors is guiding the way towards deciphering the mysteries of tolerance and physical dependence that have plagued the field and is providing a platform for the development of more effective and safer opioids.
Journal ArticleDOI
Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study.
Hang Zhou,Hang Zhou,Christopher T Rentsch,Christopher T Rentsch,Christopher T Rentsch,Zhongshan Cheng,Zhongshan Cheng,Rachel L. Kember,Rachel L. Kember,Yaira Z. Nunez,Yaira Z. Nunez,Richard Sherva,Janet P. Tate,Janet P. Tate,Cecilia Dao,Cecilia Dao,Ke Xu,Ke Xu,Renato Polimanti,Renato Polimanti,Lindsay A. Farrer,Amy C. Justice,Amy C. Justice,Henry R. Kranzler,Henry R. Kranzler,Joel Gelernter +25 more
TL;DR: A genome-wide meta-analysis identified a significant association of OUD with an OPRM1 variant, which was replicated in 2 independent samples and revealed associated pleiotropic characteristics.
References
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Journal ArticleDOI
Neurocircuitry of Addiction
George F. Koob,Nora D. Volkow +1 more
TL;DR: The delineation of the neurocircuitry of the evolving stages of the addiction syndrome forms a heuristic basis for the search for the molecular, genetic, and neuropharmacological neuroadaptations that are key to vulnerability for developing and maintaining addiction.
Journal ArticleDOI
Neurobiology of addiction: A neurocircuitry analysis.
George F. Koob,Nora D. Volkow +1 more
TL;DR: Molecular genetic studies have identified transduction and transcription factors that act in neurocircuitry associated with the development and maintenance of addiction that might mediate initial vulnerability, maintenance, and relapse associated with addiction.
Journal ArticleDOI
Brain dopamine and reward.
Roy A. Wise,Pierre-Paul Rompré +1 more
TL;DR: While the evidence is strong that dopamine plays some fundamental and special role in the rewarding effects of brain stimulation, psychomotor stimulants, opiates, and food, the exact nature of that role is not clear and dopamine is not the only reward transmitter, and dopaminergic neurons are not the final common path for all rewards.
Journal ArticleDOI
Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor.
Jean-Claude Meunier,Catherine Mollereau,Lawrence Toll,Lawrence Toll,Charles Suaudeau,Christiane Moisand,Paul Alvinerie,Jean-Luc Butour,Jean-Claude Guillemot,Pascual Ferrara,Bernard Monsarrat,Honoré Mazarguil,Gilbert Vassart,Marc Parmentier,Jean Costentin +14 more
TL;DR: Data indicate that the newly discovered heptadecapeptide is an endogenous agonist of the ORL1 receptor and that it may be endowed with pro-nociceptive properties.
Journal ArticleDOI
Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.
Rainer K. Reinscheid,Hans Peter Nothacker,Anne Bourson,Ali Ardati,Robert Henningsen,James R. Bunzow,David K. Grandy,Hanno Langen,Frederick J. Monsma,Olivier Civelli +9 more
TL;DR: Orphanin FQ may act as a transmitter in the brain by modulating nociceptive and locomotor behavior by binding to its receptor in a saturable manner and with high affinity.