Oral angiotensin-converting enzyme inhibitors for treatment of delayed inflammatory reaction to dermal hyaluronic acid fillers following COVID-19 vaccination-a model for inhibition of angiotensin II-induced cutaneous inflammation.
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TLDR
In this article, the authors present four cases of delayed inflammatory reaction (DIR) to facial dermal hyaluronic acid filler rapidly following vaccination for COVID-19. All patients responded rapidly to therapy with a low dose of oral lisinopril, an angiotensin-converting enzyme inhibitor (ACE-I), which decreases the cutaneous filler-related inflammatory reaction and edema by a novel proposed mechanism.Abstract:
We present 4 cases of delayed inflammatory reaction (DIR) to facial dermal hyaluronic acid filler rapidly following vaccination for COVID-19. All DIRs occurred after a hyaluronic acid filler had been placed more than 1 year before vaccination. All patients responded rapidly to therapy with a low dose of oral lisinopril, an angiotensin-converting enzyme inhibitor (ACE-I), which decreases the cutaneous filler-related inflammatory reaction and edema by a novel proposed mechanism.read more
Citations
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Journal ArticleDOI
Cutaneous reactions after SARS-COV-2 vaccination: A cross-sectional Spanish nationwide study of 405 cases.
A. Català,C Muñoz-Santos,Cristina Galván-Casas,M. Roncero Riesco,D Revilla Nebreda,A Solá-Truyols,Priscila Giavedoni,Mar Llamas-Velasco,Carlos González-Cruz,Xavier Cubiró,Ricardo Ruiz-Villaverde,S Gómez-Armayones,M P Gil Mateo,D Pesqué,O Marcantonio,Diego Fernandez-Nieto,Jorge Romaní,N Iglesias Pena,L Carnero Gonzalez,J Tercedor-Sanchez,Gregorio Carretero,T Masat-Ticó,Pedro Rodriguez-Jimenez,Ana Giménez-Arnau,M Utrera-Busquets,E Vargas Laguna,A G Angulo Menéndez,E San Juan Lasser,M Iglesias-Sancho,L Alonso Naranjo,I Hiltun,E Cutillas Marco,I. Polimón Olabarrieta,S. Marinero Escobedo,X García-Navarro,M J Calderón Gutiérrez,G Baeza-Hernández,L Bou Camps,T Toledo-Pastrana,Antonio Guilabert +39 more
TL;DR: The most reported reactions in each vaccine group were COVID arm (mRNA-1273, Moderna, 61·9%), varicella zoster virus reactivation (BNT162b2, Pfizer-BioNTech, 17·2%) and urticaria (AZD1222, AstraZeneca, 21·1%) as discussed by the authors.
Journal ArticleDOI
Cutaneous reactions after SARS-CoV-2 vaccination: a cross-sectional Spanish nationwide study of 405 cases
TL;DR: The most reported reactions in each vaccine group were COVID arm (mRNA-1273, Moderna, 61·9%), varicella zoster virus reactivation (BNT162b2, Pfizer-BioNTech, 17·2%) and urticaria (AZD1222, AstraZeneca, 21·1%) as mentioned in this paper .
Journal ArticleDOI
Cutaneous findings following COVID-19 vaccination: Review of world literature and own experience.
Thilo Gambichler,Stefanie Boms,Laura Susok,Heinrich Dickel,C. Finis,N. Abu Rached,M. Barras,Markus Stücker,Dimitri Kasakovski,Dimitri Kasakovski +9 more
TL;DR: There is growing evidence that not only the novel coronavirus disease (COVID-19) but also the COVID19 vaccines can cause a variety of skin reactions as mentioned in this paper, including delayed large local skin lesions, inflammatory reactions in dermal filler or previous radiation sites or even old BCG scars.
Journal ArticleDOI
COVID-19 Vaccines and the Skin: The landscape of cutaneous vaccine reactions worldwide
TL;DR: The authors reviewed the dermatologic manifestations of COVID-19 vaccines as reported in clinical trial data and summarized additional observational reports of skin reactions to COVID19 vaccines, concluding that early-onset local injection reactions were the most common cutaneous side effects observed in clinical trials, while delayed injection reactions reported outside of clinical trials.
Journal ArticleDOI
Cutaneous adverse effects of the available COVID-19 vaccines
TL;DR: In this article, a plethora of cutaneous adverse events have been reported, most of them mild or moderate injection-site reactions, posing questions on their pathophysiology and clinical importance.
References
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TL;DR: It is demonstrated, both on model surfaces and on living cells, that the receptor binding domain (RBD) serves as the binding interface within the S-glycoprotein with the ACE2 receptor and the kinetic and thermodynamic properties of this binding pocket are extracted.
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Human skin: source of and target organ for angiotensin II.
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TL;DR: The findings suggest that the complete renin–angiotensin system is present in human skin and plays a role in normal cutaneous homeostasis as well as in human cutaneous wound healing.
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Delayed-onset nodules secondary to a smooth cohesive 20 mg/mL hyaluronic acid filler: cause and management.
TL;DR: It is the authors' opinion from the patients' responses and from the literature that these nodules are immune mediated in nature and it is important to be aware of this adverse effect and have a management protocol in place.
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