Oxidative Stress and Metabolic Reprogramming in Cr(VI) Carcinogenesis.
TLDR
The current progress in the studies of metabolic reprogramming and Cr(VI) carcinogenesis is summarized with emphasis on the metabolic enzymes and oxidative stress related major oncogenic pathways.About:
This article is published in Current Opinion in Toxicology.The article was published on 2018-04-01 and is currently open access. It has received 32 citations till now. The article focuses on the topics: Metal Carcinogenesis & Carcinogenesis.read more
Citations
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The Effect of Hexavalent Chromium on the Incidence and Mortality of Human Cancers: A Meta-Analysis Based on Published Epidemiological Cohort Studies.
Yujiao Deng,Meng Wang,Meng Wang,Tian Tian,Tian Tian,Shuai Lin,Peng Xu,Linghui Zhou,Cong Dai,Qian Hao,Ying Wu,Zhen Zhai,Yue Zhu,Guihua Zhuang,Zhijun Dai,Zhijun Dai +15 more
TL;DR: There was a strong association between incidence and mortality risk of cancers and concentration of Cr(VI) in the air and the exposure time, and it is related to increased risk of overall mortality owing to lung, larynx, bladder, kidney, testicular, bone, and thyroid cancer.
Journal ArticleDOI
Porous polyacrylonitrile/graphene oxide nanofibers designed for high efficient adsorption of chromium ions (VI) in aqueous solution
Zhang-Qi Feng,Yuan Xu,Ting Wang +2 more
TL;DR: In this paper, the authors developed a new strategy for preparation of porous polyacrylonitrile (PAN)/graphene oxide (GO) nanofibers by simple one-step electrospinning of PAN/GO solution in N,N-dimethylformamide (DMF)/H2O mixed solvent.
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Metabolic Reprogramming in Cancer is Induced to Increase Proton Production
Huiyan Sun,Huiyan Sun,Yi Zhou,Michael Skaro,Yiran Wu,Zexing Qu,Fenglou Mao,Suwen Zhao,Ying Xu,Ying Xu +9 more
TL;DR: Analysis of reprogrammed metabolisms including the Warburg effect, nucleotide de novo synthesis and sialic acid biosynthesis in cancer suggests that continuous cell division and other cancerous behaviors are ways for the affected cells to remove non-proton products in a timely and sustained manner.
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Metal dyshomeostasis based biomarkers of lung cancer using human biofluids
TL;DR: It is demonstrated that several metals are good biomarkers when they are related to labile complexes, complexed with low molecular mass ligands, or in the form of metalloproteins (i.e. V and Cr in HMM and Cu in LMM), which has been described for the first time.
Journal ArticleDOI
Life Cycle Assessment for Chrome Tanning, Chrome-Free Metal Tanning, and Metal-Free Tanning Systems
TL;DR: In this paper, the life cycle assessment (LCA) was applied to compare environmental impacts of a chrome tanning system (CTS) using basic chrome sulfate (Cr), a chrome-free metal tanning systems (CFMTS) using complexes, and a chrome free metal tanner using complexes.
References
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HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
TL;DR: A hypoxia-induced metabolic switch that shunts glucose metabolites from the mitochondria to glycolysis to maintain ATP production and to prevent toxic ROS production is revealed.
Journal Article
Overexpression of Hypoxia-inducible Factor 1α in Common Human Cancers and Their Metastases
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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
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Akt stimulates aerobic glycolysis in cancer cells
Rebecca Elstrom,Daniel E. Bauer,Monica Buzzai,Robyn Karnauskas,Marian H. Harris,David R. Plas,Hongming Zhuang,Ryan M. Cinalli,Abass Alavi,Charles M. Rudin,Craig B. Thompson +10 more
TL;DR: It is suggested that activation of the Akt oncogene is sufficient to stimulate the switch to aerobic glycolysis characteristic of cancer cells and that Akt activity renders cancer cells dependent on aerobic glyCOlysis for continued growth and survival.
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