Journal ArticleDOI
Oxidative stress in carcinogenesis
James E. Klaunig,Zemin Wang +1 more
TLDR
The susceptibility to human cancers can be modified by polymorphisms in oxidative DNA repair genes and antioxidant genes, as well as xenobiotics, pharmaceuticals and radiation.About:
This article is published in Current Opinion in Toxicology.The article was published on 2018-02-01. It has received 55 citations till now. The article focuses on the topics: DNA repair & Carcinogenesis.read more
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Mutant p53-Associated Molecular Mechanisms of ROS Regulation in Cancer Cells.
Marco Cordani,Giovanna Butera,Raffaella Pacchiana,Francesca Masetto,Nidula Mullappilly,Chiara Riganti,Massimo Donadelli +6 more
TL;DR: The studies summarized here highlight that GOF mutant p53 isoforms might constitute major targets for selective therapeutic intervention against several types of tumors and that ROS enhancement driven by Mutant p53 might represent an “Achilles heel” of cancer cells, suggesting pro-oxidant drugs as a therapeutic approach for cancer patients bearing the mutant TP53 gene.
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Inula L. Secondary Metabolites against Oxidative Stress-Related Human Diseases.
TL;DR: The Inula genus is a good bet as source of structurally diverse compounds with antioxidant activity that can act via different mechanisms to fight several oxidative stress-related human diseases, being useful for development of new drugs.
Journal ArticleDOI
Medicinal Prospects of Antioxidants From Algal Sources in Cancer Therapy.
Abstract: Though cancer therapeutics can successfully eradicate cancerous cells, the effectiveness of these medications is mostly restricted to several deleterious side effects. Therefore, to alleviate these side effects, antioxidant supplementation is often warranted, reducing reactive species levels and mitigating persistent oxidative damage. Thus, it can impede the growth of cancer cells while protecting the normal cells simultaneously. Moreover, antioxidant supplementation alone or in combination with chemotherapeutics hinders further tumor development, prevents chemoresistance by improving the response to chemotherapy drugs, and enhances cancer patients' quality of life by alleviating side effects. Preclinical and clinical studies have been revealed the efficacy of using phytochemical and dietary antioxidants from different sources in treating chemo and radiation therapy-induced toxicities and enhancing treatment effectiveness. In this context, algae, both micro and macro, can be considered as alternative natural sources of antioxidants. Algae possess antioxidants from diverse groups, which can be exploited in the pharmaceutical industry. Despite having nutritional benefits, investigation and utilization of algal antioxidants are still in their infancy. This review article summarizes the prospective anticancer effect of twenty-three antioxidants from microalgae and their potential mechanism of action in cancer cells, as well as usage in cancer therapy. In addition, antioxidants from seaweeds, especially from edible species, are outlined, as well.
Journal ArticleDOI
The nanoencapsulation of curcuminoids extracted from Curcuma longa L. and an evaluation of their cytotoxic, enzymatic, antioxidant and anti-inflammatory activities
Priscila Dayane Freitas dos Santos,Cristhian Rafael Lopes Francisco,Aline Coqueiro,Fernanda Vitória Leimann,Fernanda Vitória Leimann,José Pinela,Ricardo C. Calhelha,Rafael Porto Ineu,Isabel C.F.R. Ferreira,Evandro Bona,Odinei Hess Gonçalves,Odinei Hess Gonçalves +11 more
TL;DR: Encapsulated curcuminoid nanoparticles significantly inhibited the in vitro activity of AChE and GST and presented antioxidant activity and toxic effects against breast adenocarcinoma, lung, cervical and hepatocellular carcinoma cells when dispersed in water.
Journal ArticleDOI
Oxidative Stress and Neonatal Respiratory Extracorporeal Membrane Oxygenation.
Genny Raffaeli,Stefano Ghirardello,Sofia Passera,Sofia Passera,Fabio Mosca,Fabio Mosca,Giacomo Cavallaro +6 more
TL;DR: An overview of the clinical impact of the oxidative stress during neonatal extracorporeal support is provided and a brief perspective on the current antioxidant strategies are concluded, with the aim to focus on the potential oxidative stress-mediated cell damage that has been implicated in both short and long-term outcomes.
References
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Journal ArticleDOI
Free radicals, metals and antioxidants in oxidative stress-induced cancer
TL;DR: This review examines the evidence for involvement of the oxidative stress in the carcinogenesis process and the role of enzymatic and non-enzymatic antioxidants in the process of carcinogenesis as well as the antioxidant interactions with various regulatory factors.
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Casarett and Doull's toxicology : the basic science of poisons
TL;DR: Casarett and Doull's Toxicology: The Basic Science of Poisons as mentioned in this paper is the most complete and up-to-date overview of the biomedical and environmental aspects of toxicology.
Journal ArticleDOI
Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway
TL;DR: The development of Nrf2 knockout mice has provided key insights into the toxicological importance of this pathway, and this review highlights the key elements in this adaptive response to protection against acute and chronic cell injury provoked by environmental stresses.
Journal ArticleDOI
Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements
TL;DR: It is demonstrated that multiple synthetic copies of the consensus AP-1-binding site can act as TPA-inducible enhancers in various plasmid constructs after transfection into HeLa cells, suggesting that AP- 1 is a transcription factor that functions by interacting with a specific enhancer element, and that its activities may be modulated by treatment of cells with TPA.
Journal ArticleDOI
Oxyradicals and DNA damage
TL;DR: The levels of oxidative DNA damage reported in many human tissues or in animal models of carcinogenesis exceed the levels of lesions induced by exposure to exogenous carcinogenic compounds, and it seems likely that oxidativeDNA damage is important in the etiology of many human cancers.