Journal ArticleDOI
Oxidative stress and vascular inflammation in aging
TLDR
Lifestyle attitudes such as caloric restriction and exercise training appear as effective ways to overcome defective antioxidant response and inflammation, favoring successful vascular aging and decreasing the risk for cardiovascular disease.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2013-12-01. It has received 443 citations till now. The article focuses on the topics: SOD2 & Oxidative stress.read more
Citations
More filters
Journal Article
Abstract 1229: Molecular Mechanisms of Angiotensin II-Mediated Mitochondrial Dysfunction: Linking Mitochondrial Oxidative Damage and Vascular Endothelial Dysfunction
TL;DR: Mitochondrial dysfunction in response to Ang II modulates endothelial NO˙ and &OV0151; generation, which in turn has ramifications for development of endothelial dysfunction.
Journal ArticleDOI
Oxidative stress response and Nrf2 signaling in aging.
TL;DR: This review summarizes current studies on age-related impairment of Nrf2/EpRE function and discusses the changes in NRF2 regulatory mechanisms with aging.
Journal ArticleDOI
Targeting vascular (endothelial) dysfunction
Andreas Daiber,Sebastian Steven,Alina Weber,Vladimir V. Shuvaev,Vladimir R. Muzykantov,Ismail Laher,Huige Li,Santiago Lamas,Thomas Münzel +8 more
TL;DR: Assessing vascular function, including that of smooth muscle and even perivascular adipose tissue, may be an appropriate parameter for clinical investigations, and alternative diagnostic parameters such as vascular stiffness index and intima/media thickness ratio are discussed.
Journal ArticleDOI
Vascular Inflammation and Oxidative Stress: Major Triggers for Cardiovascular Disease
Sebastian Steven,Katie Frenis,Matthias Oelze,Sanela Kalinovic,Marin Kuntic,Maria Teresa Bayo Jimenez,Ksenija Vujacic-Mirski,Johanna Helmstädter,Swenja Kröller-Schön,Thomas Münzel,Andreas Daiber +10 more
TL;DR: The value of immunomodulation for the treatment of cardiovascular disease was recently supported by large-scale clinical trials demonstrating reduced cardiovascular mortality in patients with established atherosclerotic disease when treated by highly specific anti-inflammatory therapies.
Journal ArticleDOI
Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine
TL;DR: It is demonstrated that H2 reacts with strong oxidants such as hydroxyl radical in cells, and its potential for preventive and therapeutic applications is proposed, indicating its promising potential for clinical use against many diseases.
References
More filters
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
Aging: A Theory Based on Free Radical and Radiation Chemistry
TL;DR: It seems possible that one factor in aging may be related to deleterious side attacks of free radicals (which are normally produced in the course of cellular metabolism) on cell constituents.
Journal ArticleDOI
Hydroperoxide metabolism in mammalian organs.
Book
The Stress of Life
TL;DR: In this paper, the discovery of stress, the dissection of stress the disease of adaptation sketch for a unified theory implications and applications is described, and the authors propose a unified framework for adaptation.
Journal ArticleDOI
Nitric Oxide and Peroxynitrite in Health and Disease
TL;DR: Current evidence indicates that most of the cytotoxicity attributed to NO is rather due to peroxynitrite, produced from the diffusion-controlled reaction between NO and another free radical, the superoxide anion, which is presented in detail in this review.
Related Papers (5)
Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises Part I: Aging Arteries: A “Set Up” for Vascular Disease
Edward G. Lakatta,Daniel Levy +1 more