p53 as guardian of the mitochondrial genome
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TLDR
The evidence for the involvement of p53 in maintaining the integrity of mtDNA through its activities in both the nucleus and the mitochondria is reviewed.About:
This article is published in FEBS Letters.The article was published on 2016-04-01 and is currently open access. It has received 104 citations till now. The article focuses on the topics: Mitochondrial DNA & DNA repair.read more
Citations
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Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming.
TL;DR: Conceptualising the distinct similarity between tumorigenesis and cellular reprogramming, this review provides a perspective discussion on involvement of SIRT1 in improving efficiency in the induction and maintenance of pluripotent state.
Journal ArticleDOI
Mitochondrial Nucleoid: Shield and Switch of the Mitochondrial Genome.
Sung Ryul Lee,Jin Han +1 more
TL;DR: In this review, mitochondrial nucleoid structure, nucleoid-associated proteins, and their regulatory roles in mitochondrial metabolism are briefly addressed to provide an overview of the emerging research field involving mitochondrial biology.
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SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease.
Junghee Lee,Junghee Lee,Y. S. Kim,Tian Liu,Yu Jin Hwang,Seung Jae Hyeon,Hyeonjoo Im,Kyung-Eun Lee,Victor E. Alvarez,Victor E. Alvarez,Ann C. McKee,Ann C. McKee,Soo-Jong Um,Man-Wook Hur,Inhee Mook-Jung,Neil W. Kowall,Neil W. Kowall,Hoon Ryu,Hoon Ryu,Hoon Ryu +19 more
TL;DR: Therapeutic modulation of SIRT3 activity may ameliorate mitochondrial pathology and neurodegeneration in AD and prevent p53‐induced mitochondrial dysfunction and neuronal damage in AD.
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Unravelling the mechanisms regulating muscle mitochondrial biogenesis.
TL;DR: An optimistic outlook is offered in which the maintenance of mitochondrial and whole-body metabolic health can be achieved by taking advantage of the broad benefits of exercise, along with the potential specificity of drug action.
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Metabolic Reprogramming in Breast Cancer and Its Therapeutic Implications.
Nishant Gandhi,Gokul M. Das +1 more
TL;DR: For metabolic therapy to be efficacious there is a need to understand the metabolic underpinnings of the different subtypes of breast cancer as well as the role the SOC treatments play in targeting the metabolic phenotype.
References
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Surfing the p53 network
TL;DR: The p53 tumour-suppressor gene integrates numerous signals that control cell life and death, and the disruption of p53 has severe consequences when a highly connected node in the Internet breaks down.
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A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine
TL;DR: The mitochondria provide a direct link between the authors' environment and their genes and the mtDNA variants that permitted their forbears to energetically adapt to their ancestral homes are influencing their health today.